α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Published in Nature communications (12.06.2018)
Published in Nature communications (12.06.2018)
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Journal Article
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Published in Cell death and differentiation (01.10.2020)
Published in Cell death and differentiation (01.10.2020)
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Journal Article
A sticky situation: Aberrant protein–protein interactions in Parkinson’s disease
Brown, James, Horrocks, Mathew H.
Published in Seminars in cell & developmental biology (01.03.2020)
Published in Seminars in cell & developmental biology (01.03.2020)
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Journal Article
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
Benson, Sam, Fernandez, Antonio, Barth, Nicole D., de Moliner, Fabio, Horrocks, Mathew H., Herrington, C. Simon, Abad, Jose Luis, Delgado, Antonio, Kelly, Lisa, Chang, Ziyuan, Feng, Yi, Nishiura, Miyako, Hori, Yuichiro, Kikuchi, Kazuya, Vendrell, Marc
Published in Angewandte Chemie International Edition (20.05.2019)
Published in Angewandte Chemie International Edition (20.05.2019)
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Journal Article
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Journal Article
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
Shammas, Sarah L., Garcia, Gonzalo A., Kumar, Satish, Kjaergaard, Magnus, Horrocks, Mathew H., Shivji, Nadia, Mandelkow, Eva, Knowles, Tuomas P.J., Mandelkow, Eckhard, Klenerman, David
Published in Nature communications (30.04.2015)
Published in Nature communications (30.04.2015)
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Journal Article
Lipid peroxidation is essential for α‐synuclein‐induced cell death
Angelova, Plamena R., Horrocks, Mathew H., Klenerman, David, Gandhi, Sonia, Abramov, Andrey Y., Shchepinov, Mikhail S.
Published in Journal of neurochemistry (01.05.2015)
Published in Journal of neurochemistry (01.05.2015)
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Journal Article
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping
Bongiovanni, Marie N., Godet, Julien, Horrocks, Mathew H., Tosatto, Laura, Carr, Alexander R., Wirthensohn, David C., Ranasinghe, Rohan T., Lee, Ji-Eun, Ponjavic, Aleks, Fritz, Joelle V., Dobson, Christopher M., Klenerman, David, Lee, Steven F.
Published in Nature communications (08.12.2016)
Published in Nature communications (08.12.2016)
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Journal Article
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
Deas, Emma, Cremades, Nunilo, Angelova, Plamena R, Ludtmann, Marthe H R, Yao, Zhi, Chen, Serene, Horrocks, Mathew H, Banushi, Blerida, Little, Daniel, Devine, Michael J, Gissen, Paul, Klenerman, David, Dobson, Christopher M, Wood, Nicholas W, Gandhi, Sonia, Abramov, Andrey Y
Published in Antioxidants & redox signaling (01.03.2016)
Published in Antioxidants & redox signaling (01.03.2016)
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Journal Article
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Choi, Minee L., Chappard, Alexandre, Singh, Bhanu P., Maclachlan, Catherine, Rodrigues, Margarida, Fedotova, Evgeniya I., Berezhnov, Alexey V., De, Suman, Peddie, Christopher J., Athauda, Dilan, Virdi, Gurvir S., Zhang, Weijia, Evans, James R., Wernick, Anna I., Zanjani, Zeinab Shadman, Angelova, Plamena R., Esteras, Noemi, Vinokurov, Andrey Y., Morris, Katie, Jeacock, Kiani, Tosatto, Laura, Little, Daniel, Gissen, Paul, Clarke, David J., Kunath, Tilo, Collinson, Lucy, Klenerman, David, Abramov, Andrey Y., Horrocks, Mathew H., Gandhi, Sonia
Published in Nature neuroscience (01.09.2022)
Published in Nature neuroscience (01.09.2022)
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Journal Article
Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain
Colom-Cadena, Martí, Davies, Caitlin, Sirisi, Sònia, Lee, Ji-Eun, Simzer, Elizabeth M., Tzioras, Makis, Querol-Vilaseca, Marta, Sánchez-Aced, Érika, Chang, Ya Yin, Holt, Kristjan, McGeachan, Robert I., Rose, Jamie, Tulloch, Jane, Wilkins, Lewis, Smith, Colin, Andrian, Teodora, Belbin, Olivia, Pujals, Sílvia, Horrocks, Mathew H., Lleó, Alberto, Spires-Jones, Tara L.
Published in Neuron (Cambridge, Mass.) (19.07.2023)
Published in Neuron (Cambridge, Mass.) (19.07.2023)
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Journal Article
Ubiquitin chain conformation regulates recognition and activity of interacting proteins
Ye, Yu, Blaser, Georg, Horrocks, Mathew H., Ruedas-Rama, Maria J., Ibrahim, Shehu, Zhukov, Alexander A., Orte, Angel, Klenerman, David, Jackson, Sophie E., Komander, David
Published in Nature (London) (13.12.2012)
Published in Nature (London) (13.12.2012)
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Journal Article
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Angelova, Plamena R, Ludtmann, Marthe H R, Horrocks, Mathew H, Negoda, Alexander, Cremades, Nunilo, Klenerman, David, Dobson, Christopher M, Wood, Nicholas W, Pavlov, Evgeny V, Gandhi, Sonia, Abramov, Andrey Y
Published in Journal of cell science (01.05.2016)
Published in Journal of cell science (01.05.2016)
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Journal Article
Mapping Surface Hydrophobicity of α‑Synuclein Oligomers at the Nanoscale
Lee, Ji-Eun, Sang, Jason C, Rodrigues, Margarida, Carr, Alexander R, Horrocks, Mathew H, De, Suman, Bongiovanni, Marie N, Flagmeier, Patrick, Dobson, Christopher M, Wales, David J, Lee, Steven F, Klenerman, David
Published in Nano letters (12.12.2018)
Published in Nano letters (12.12.2018)
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Journal Article
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
Cox, Dezerae, Whiten, Daniel R., Brown, James W.P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M., Ecroyd, Heath
Published in The Journal of biological chemistry (23.03.2018)
Published in The Journal of biological chemistry (23.03.2018)
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Journal Article
Lipid-induced polymorphic amyloid fibril formation by α-synuclein
Singh, Bhanu P, Morris, Ryan J, Kunath, Tilo, MacPhee, Cait E, Horrocks, Mathew H
Published in Protein science (01.10.2023)
Published in Protein science (01.10.2023)
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Journal Article
Live‐cell super‐resolution imaging of actin using LifeAct‐14 with a PAINT‐based approach
Bhaskar, Haresh, Kleinjan, Dirk‐Jan, Oi, Curran, Gidden, Zoe, Rosser, Susan J., Horrocks, Mathew H., Regan, Lynne
Published in Protein science (01.02.2023)
Published in Protein science (01.02.2023)
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Journal Article
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
Kundel, Franziska, De, Suman, Flagmeier, Patrick, Horrocks, Mathew H, Kjaergaard, Magnus, Shammas, Sarah L, Jackson, Sophie E, Dobson, Christopher M, Klenerman, David
Published in ACS chemical biology (16.03.2018)
Published in ACS chemical biology (16.03.2018)
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Journal Article
Probing TDP-43 condensation using an in silico designed aptamer
Zacco, Elsa, Kantelberg, Owen, Milanetti, Edoardo, Armaos, Alexandros, Panei, Francesco Paolo, Gregory, Jenna, Jeacock, Kiani, Clarke, David J., Chandran, Siddharthan, Ruocco, Giancarlo, Gustincich, Stefano, Horrocks, Mathew H., Pastore, Annalisa, Tartaglia, Gian Gaetano
Published in Nature communications (23.06.2022)
Published in Nature communications (23.06.2022)
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Journal Article
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits
Broadhead, Matthew J., Horrocks, Mathew H., Zhu, Fei, Muresan, Leila, Benavides-Piccione, Ruth, DeFelipe, Javier, Fricker, David, Kopanitsa, Maksym V., Duncan, Rory R., Klenerman, David, Komiyama, Noboru H., Lee, Steven F., Grant, Seth G. N.
Published in Scientific reports (25.04.2016)
Published in Scientific reports (25.04.2016)
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