AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
Zabludoff, Sonya D, Deng, Chun, Grondine, Michael R, Sheehy, Adam M, Ashwell, Susan, Caleb, Benjamin L, Green, Stephen, Haye, Heather R, Horn, Candice L, Janetka, James W, Liu, Dongfang, Mouchet, Elizabeth, Ready, Shannon, Rosenthal, Judith L, Queva, Christophe, Schwartz, Gary K, Taylor, Karen J, Tse, Archie N, Walker, Graeme E, White, Anne M
Published in Molecular cancer therapeutics (01.09.2008)
Published in Molecular cancer therapeutics (01.09.2008)
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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
CARPTEN, John D, FABER, Andrew L, UHLIK, Mark, LIN, Aimin, JIAN DU, QIAN, Yue-Wei, ZECKNER, Douglas J, TUCKER-KELLOGG, Greg, TOUCHMAN, Jeffrey, PATEL, Ketan, MOUSSES, Spyro, BITTNER, Michael, HORN, Candice, SCHEVITZ, Richard, LAI, Mei-Huei T, BLANCHARD, Kerry L, THOMAS, James E, DONOHO, Gregory P, BRIGGS, Stephen L, ROBBINS, Christiane M, HOSTETTER, Galen, BOGUSLAWSKI, Sophie, MOSES, Tracy Y, SAVAGE, Stephanie
Published in Nature (26.07.2007)
Published in Nature (26.07.2007)
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Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas
Oza, Vibha, Ashwell, Susan, Almeida, Lynsie, Brassil, Patrick, Breed, Jason, Deng, Chun, Gero, Thomas, Grondine, Michael, Horn, Candice, Ioannidis, Stephanos, Liu, Dongfang, Lyne, Paul, Newcombe, Nicholas, Pass, Martin, Read, Jon, Ready, Shannon, Rowsell, Siân, Su, Mei, Toader, Dorin, Vasbinder, Melissa, Yu, Dingwei, Yu, Yan, Xue, Yafeng, Zabludoff, Sonya, Janetka, James
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Phase I dose escalation and pharmacokinetic evaluation of two different schedules of LY2334737, an oral gemcitabine prodrug, in patients with advanced solid tumors
Faivre, Sandrine J., Olszanski, Anthony J., Weigang-Köhler, Karin, Riess, Hanno, Cohen, Roger B., Wang, Xuejing, Myrand, Scott P., Wickremsinhe, Enaksha R., Horn, Candice L., Ouyang, Haojun, Callies, Sophie, Benhadji, Karim A., Raymond, Eric
Published in Investigational new drugs (01.12.2015)
Published in Investigational new drugs (01.12.2015)
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Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors
Janetka, James W., Almeida, Lynsie, Ashwell, Susan, Brassil, Patrick J., Daly, Kevin, Deng, Chun, Gero, Thomas, Glynn, Roberta E., Horn, Candice L., Ioannidis, Stephanos, Lyne, Paul, Newcombe, Nicholas J., Oza, Vibha B., Pass, Martin, Springer, Stephanie K., Su, Mei, Toader, Dorin, Vasbinder, Melissa M., Yu, Dingwei, Yu, Yan, Zabludoff, Sonya D.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon
ZINDA, Michael J, JOHNSON, Mac A, GRAFF, Jeremy R, PAUL, Jonathan D, HORN, Candice, KONICEK, Bruce W, LU, Zhao Hai, SANDUSKY, George, THOMAS, James E, NEUBAUER, Blake Lee, LAI, Mei T
Published in Clinical cancer research (01.08.2001)
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Published in Clinical cancer research (01.08.2001)
Journal Article
Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration
Oza, Vibha, Ashwell, Susan, Brassil, Patrick, Breed, Jason, Deng, Chun, Ezhuthachan, Jay, Haye, Heather, Horn, Candice, Janetka, James, Lyne, Paul, Newcombe, Nicholas, Otterbien, Ludo, Pass, Martin, Read, Jon, Roswell, Sian, Su, Mei, Toader, Dorin, Yu, Dingwei, Yu, Yan, Valentine, Anna, Webborn, Peter, White, Ann, Zabludoff, Sonya, Zheng, Xiaolan
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Abstract 29: Concordance of somatic mutations found in primary tumors and plasma circulating-free DNA from early and late-stage colorectal cancer patients
Bray, Steven M., Ebert, Philip J., Calley, John N., Higgs, Richard E., Wulur, Isabella H., Wong, Swee Seong, Horn, Candice L., Martinez, Ricardo, Reinhard, Christoph
Published in Clinical cancer research (01.01.2016)
Published in Clinical cancer research (01.01.2016)
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Abstract LB-048: Copy number and loss of heterozygosity (LOH) analysis in 52 breast cancer FFPE samples using molecular Inversion probe array: detailed analysis of reproducibility and performance compared to NGS platforms
Horn, Candice L., Nunes, Fabio, Calley, John, Bray, Steven, Wulur, Isabella, Farmen, Mark, Gallavan, Robert, Halfpenny, Iris, Medlow, Paul, McGreeghan-Crosby, Keith, Jellema, Gera
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 4925: Liquid biopsy using the ion AmpliSeq v2 cancer panel
Liu, WeiHua, Yan, Zhenyu, Horn, Candice L., Nunes, Fabio, Bray, Steven M., Ebert, Philip J., Fang, Peng, Biroschak, Jennifer, Spittle, Cindy, Galderisi, Chad, Li, Jin
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract 2730: Early development of ALK clinical genetic biomarkers for cancer
Freeman, Angela B., Horn, Candice, Thomas, James E., Landschulz, Katherine
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
Oza, Vibha, Ashwell, Susan, Brassil, Patrick, Breed, Jason, Ezhuthachan, Jaychandran, Deng, Chun, Grondine, Michael, Horn, Candice, Liu, DongFang, Lyne, Paul, Newcombe, Nicholas, Pass, Martin, Read, Jon, Su, Mei, Toader, Dorin, Yu, Dingwei, Yu, Yan, Zabludoff, Sonya
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
Published in Bioorganic & medicinal chemistry letters (15.03.2012)
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Journal Article
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms
Meier, Timothy I, Cook, James A, Thomas, James E, Radding, Jeffrey A, Horn, Candice, Lingaraj, Trupti, Smith, Michele C
Published in Protein expression and purification (01.06.2004)
Published in Protein expression and purification (01.06.2004)
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