Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?
Whyte, Lauren S., Lau, Adeline A., Hemsley, Kim M., Hopwood, John J., Sargeant, Timothy J.
Published in Journal of neurochemistry (01.03.2017)
Published in Journal of neurochemistry (01.03.2017)
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A Preclinical Study Evaluating AAVrh10-Based Gene Therapy for Sanfilippo Syndrome
Winner, Leanne K, Beard, Helen, Hassiotis, Sofia, Lau, Adeline A, Luck, Amanda J, Hopwood, John J, Hemsley, Kim M
Published in Human gene therapy (01.05.2016)
Published in Human gene therapy (01.05.2016)
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Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate
He, Qi Qi, Trim, Paul J., Snel, Marten F., Hopwood, John J., Ferro, Vito
Published in Organic & biomolecular chemistry (21.11.2018)
Published in Organic & biomolecular chemistry (21.11.2018)
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Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation
Witt, Rochelle M., Hecht, Marie-Lyn, Pazyra-Murphy, Maria F., Cohen, Samuel M., Noti, Christian, van Kuppevelt, Toin H., Fuller, Maria, Chan, Jennifer A., Hopwood, John J., Seeberger, Peter H., Segal, Rosalind A.
Published in The Journal of biological chemistry (06.09.2013)
Published in The Journal of biological chemistry (06.09.2013)
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Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes
Fraldi, Alessandro, Hemsley, Kim, Crawley, Allison, Lombardi, Alessia, Lau, Adeline, Sutherland, Leanne, Auricchio, Alberto, Ballabio, Andrea, Hopwood, John J.
Published in Human molecular genetics (15.11.2007)
Published in Human molecular genetics (15.11.2007)
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Journal Article
Effect of lysosomal storage on bis(monoacylglycero)phosphate
Meikle, Peter J, Duplock, Stephen, Blacklock, David, Whitfield, Phillip D, Macintosh, Gemma, Hopwood, John J, Fuller, Maria
Published in Biochemical journal (01.04.2008)
Published in Biochemical journal (01.04.2008)
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Journal Article
Long-term follow-up of endurance and safety outcomes during enzyme replacement therapy for mucopolysaccharidosis VI: Final results of three clinical studies of recombinant human N-acetylgalactosamine 4-sulfatase
Harmatz, Paul, Giugliani, Roberto, D. Schwartz, Ida Vanessa, Guffon, Nathalie, Teles, Elisa Leão, Miranda, M. Clara Sá, Wraith, J. Edmond, Beck, Michael, Arash, Laila, Scarpa, Maurizio, Ketteridge, David, Hopwood, John J., Plecko, Barbara, Steiner, Robert, Whitley, Chester B., Kaplan, Paige, Yu, Zi-Fan, Swiedler, Stuart J., Decker, Celeste
Published in Molecular genetics and metabolism (01.08.2008)
Published in Molecular genetics and metabolism (01.08.2008)
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Glycosphingolipid analysis in a naturally occurring ovine model of acute neuronopathic Gaucher disease
Karageorgos, Litsa, Hein, Leanne, Rozaklis, Tina, Adams, Melissa, Duplock, Stephen, Snel, Marten, Hemsley, Kim, Kuchel, Tim, Smith, Nicholas, Hopwood, John J
Published in Neurobiology of disease (01.07.2016)
Published in Neurobiology of disease (01.07.2016)
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Journal Article
Determination of the role of injection site on the efficacy of intra-CSF enzyme replacement therapy in MPS IIIA mice
Beard, Helen, Luck, Amanda J., Hassiotis, Sofia, King, Barbara, Trim, Paul J., Snel, Marten F., Hopwood, John J., Hemsley, Kim M.
Published in Molecular genetics and metabolism (01.05.2015)
Published in Molecular genetics and metabolism (01.05.2015)
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Journal Article
Direct comparison of measures of endurance, mobility, and joint function during enzyme-replacement therapy of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): results after 48 weeks in a phase 2 open-label clinical study of recombinant human N-acetylgalactosamine 4-sulfatase
Harmatz, Paul, Ketteridge, David, Giugliani, Roberto, Guffon, Natalie, Teles, Elisa Leão, Miranda, M Clara Sá, Yu, Zi-Fan, Swiedler, Stuart J, Hopwood, John J
Published in Pediatrics (Evanston) (01.06.2005)
Published in Pediatrics (Evanston) (01.06.2005)
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Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease
Whyte, Lauren S., Hemsley, Kim M., Lau, Adeline A., Hassiotis, Sofia, Saito, Takashi, Saido, Takaomi C., Hopwood, John J., Sargeant, Timothy J.
Published in Behavioural brain research (15.01.2018)
Published in Behavioural brain research (15.01.2018)
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Determination of urinary oligosaccharides by high-performance liquid chromatography/electrospray ionization–tandem mass spectrometry: Application to Hunter syndrome
Nielsen, Timothy C., Rozek, Tomas, Hopwood, John J., Fuller, Maria
Published in Analytical biochemistry (15.07.2010)
Published in Analytical biochemistry (15.07.2010)
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Lipid composition of microdomains is altered in a cell model of Gaucher disease
Hein, Leanne K., Duplock, Stephen, Hopwood, John J., Fuller, Maria
Published in Journal of lipid research (01.08.2008)
Published in Journal of lipid research (01.08.2008)
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Enzyme replacement reduces neuropathology in MPS IIIA dogs
Crawley, Allison C, Marshall, Neil, Beard, Helen, Hassiotis, Sofia, Walsh, Vicki, King, Barbara, Hucker, Nicola, Fuller, Maria, Jolly, Robert D, Hopwood, John J, Hemsley, Kim M
Published in Neurobiology of disease (01.08.2011)
Published in Neurobiology of disease (01.08.2011)
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Journal Article
Stop-codon read-through for patients affected by a lysosomal storage disorder
Brooks, Doug A., Muller, Viv J., Hopwood, John J.
Published in Trends in molecular medicine (01.08.2006)
Published in Trends in molecular medicine (01.08.2006)
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Examination of intravenous and intra-CSF protein delivery for treatment of neurological disease
Hemsley, Kim M., Luck, Amanda J., Crawley, Allison C., Hassiotis, Sofia, Beard, Helen, King, Barbara, Rozek, Tomas, Rozaklis, Tina, Fuller, Maria, Hopwood, John J.
Published in The European journal of neuroscience (01.03.2009)
Published in The European journal of neuroscience (01.03.2009)
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Journal Article
A Comparative Effectiveness Study of Newborn Screening Methods for Four Lysosomal Storage Disorders
Sanders, Karen A, Gavrilov, Dimitar K, Oglesbee, Devin, Raymond, Kimiyo M, Tortorelli, Silvia, Hopwood, John J, Lorey, Fred, Majumdar, Ramanath, Kroll, Charles A, McDonald, Amber M, Lacey, Jean M, Turgeon, Coleman T, Tucker, Justin N, Tang, Hao, Currier, Robert, Isaya, Grazia, Rinaldo, Piero, Matern, Dietrich
Published in International journal of neonatal screening (01.06.2020)
Published in International journal of neonatal screening (01.06.2020)
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Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer’s disease
Whyte, Lauren S., Fourrier, Célia, Hassiotis, Sofia, Lau, Adeline A., Trim, Paul J., Hein, Leanne K., Hattersley, Kathryn J., Bensalem, Julien, Hopwood, John J., Hemsley, Kim M., Sargeant, Timothy J.
Published in IBRO neuroscience reports (01.06.2022)
Published in IBRO neuroscience reports (01.06.2022)
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