Discovery of a Human Liver Glycogen Phosphorylase Inhibitor that Lowers Blood Glucose in vivo
Martin, William H., Hoover, Dennis J., Armento, Sandra J., Stock, Ingrid A., McPherson, R. Kirk, Danley, Dennis E., Stevenson, Ralph W., Barrett, Eugene J., Treadway, Judith L.
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.1998)
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Journal Article
Establishment of Correlation between in Vitro Enzyme Binding Potency and in Vivo Pharmacological Activity: Application to Liver Glycogen Phosphorylase a Inhibitors
Yu, Li J, Chen, Yue, Treadway, Judith L, McPherson, R Kirk, McCoid, Scott C, Gibbs, E Michael, Hoover, Dennis J
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
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Journal Article
Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase
Harwood, H. James, Petras, Stephen F., Hoover, Dennis J., Mankowski, Dayna C., Soliman, Victor F., Sugarman, Eliot D., Hulin, Bernard, Kwon, Younggil, Gibbs, E. Michael, Mayne, James T., Treadway, Judith L.
Published in Journal of lipid research (01.03.2005)
Published in Journal of lipid research (01.03.2005)
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Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
Patel, Nandini C, Schwarz, Jacob, Hou, Xinjun J, Hoover, Dennis J, Xie, Longfei, Fliri, Anton J, Gallaschun, Randall J, Lazzaro, John T, Bryce, Dianne K, Hoffmann, William E, Hanks, Ashley N, McGinnis, Dina, Marr, Eric S, Gazard, Justin L, Hajós, Mihály, Scialis, Renato J, Hurst, Raymond S, Shaffer, Christopher L, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
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Journal Article
Nonpeptidic Lysosomal Modulators Derived from Z‑Phe-Ala-Diazomethylketone for Treating Protein Accumulation Diseases
Viswanathan, Kishore, Hoover, Dennis J, Hwang, Jeannie, Wisniewski, Meagan L, Ikonne, Uzoma S, Bahr, Ben A, Wright, Dennis L
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
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Journal Article
Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase
Hoover, Dennis J, Lefkowitz-Snow, Sheri, Burgess-Henry, Jana L, Martin, William H, Armento, Sandra J, Stock, Ingrid A, McPherson, R. Kirk, Genereux, Paul E, Gibbs, E. Michael, Treadway, Judith L
Published in Journal of medicinal chemistry (30.07.1998)
Published in Journal of medicinal chemistry (30.07.1998)
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Journal Article
A simple method for the formation of cyclopropylamines: the first synthesis of tricyclopropylamine
Gillaspy, Melissa L., Lefker, Bruce A., Hada, William A, Hoover, Dennis J.
Published in Tetrahedron letters (09.10.1995)
Published in Tetrahedron letters (09.10.1995)
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Journal Article
Synthesis and crystallographic analysis of two rhizopuspepsin inhibitor complexes
Parris, Kevin D, Hoover, Dennis J, Damon, David B, Davies, David R
Published in Biochemistry (Easton) (01.09.1992)
Published in Biochemistry (Easton) (01.09.1992)
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Journal Article
Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus
Treadway, J L, Mendys, P, Hoover, D J
Published in Expert opinion on investigational drugs (01.03.2001)
Published in Expert opinion on investigational drugs (01.03.2001)
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Journal Article
Human liver glycogen phosphorylase inhibitors bind at a new allosteric site
Rath, Virginia L, Ammirati, Mark, Danley, Dennis E, Ekstrom, Jennifer L, Gibbs, E Michael, Hynes, Thomas R, Mathiowetz, Alan M, McPherson, R Kirk, Olson, Thanh V, Treadway, Judith L, Hoover, Dennis J
Published in Chemistry & biology (01.09.2000)
Published in Chemistry & biology (01.09.2000)
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Journal Article
Structure-Activity Analysis of the Purine Binding Site of Human Liver Glycogen Phosphorylase
Ekstrom, Jennifer L, Pauly, Thomas A, Carty, Maynard D, Soeller, Walter C, Culp, Jeff, Danley, Dennis E, Hoover, Dennis J, Treadway, Judith L, Gibbs, E.Michael, Fletterick, Robert J, Day, Yasmina S.N, Myszka, David G, Rath, Virginia L
Published in Chemistry & biology (01.08.2002)
Published in Chemistry & biology (01.08.2002)
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Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases
Veerapandian, B., Cooper, Jon B., Šali, Andrej, Blundell, Tom L., Rosati, Robert L., Dominy, Beryl W., Damon, David B., Hoover, Dennis J.
Published in Protein science (01.03.1992)
Published in Protein science (01.03.1992)
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Journal Article
The Indole-2-Carboxamide Glycogen Phosphorylase Inhibitor CP-320626 Lowers Plasma Cholesterol via Lanosterol 14[Alpha]-Demethylase
TREADWAY, JUDITH L, PETRAS, STEPHEN F, HOOVER, DENNIS J, KWON, YOUNGGIL, MANKOWSKI, DAYNA C, MAYNE, JAMES T, HARWOOD, H J
Published in Diabetes (New York, N.Y.) (01.05.1999)
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Published in Diabetes (New York, N.Y.) (01.05.1999)
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