GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.
Published in Scientific reports (06.03.2017)
Published in Scientific reports (06.03.2017)
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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
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Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148
Mackman, Richard L., Ray, Adrian S., Hui, Hon C., Zhang, Lijun, Birkus, Gabriel, Boojamra, Constantine G., Desai, Manoj C., Douglas, Janet L., Gao, Ying, Grant, Deborah, Laflamme, Genevieve, Lin, Kuei-Ying, Markevitch, David Y., Mishra, Ruchika, McDermott, Martin, Pakdaman, Rowchanak, Petrakovsky, Oleg V., Vela, Jennifer E., Cihlar, Tomas
Published in Bioorganic & medicinal chemistry (15.05.2010)
Published in Bioorganic & medicinal chemistry (15.05.2010)
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Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C‑Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
Mackman, Richard L, Hui, Hon C, Perron, Michel, Murakami, Eisuke, Palmiotti, Christopher, Lee, Gary, Stray, Kirsten, Zhang, Lijun, Goyal, Bindu, Chun, Kwon, Byun, Daniel, Siegel, Dustin, Simonovich, Scott, Du Pont, Venice, Pitts, Jared, Babusis, Darius, Vijjapurapu, Arya, Lu, Xianghan, Kim, Cynthia, Zhao, Xiaofeng, Chan, Julie, Ma, Bin, Lye, Diane, Vandersteen, Adelle, Wortman, Sarah, Barrett, Kimberly T, Toteva, Maria, Jordan, Robert, Subramanian, Raju, Bilello, John P, Cihlar, Tomas
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode: Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa
Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates
Mackman, Richard L., Boojamra, Constantine G., Prasad, Vidya, Zhang, Lijun, Lin, Kuei-Ying, Petrakovsky, Oleg, Babusis, Darius, Chen, James, Douglas, Janet, Grant, Deborah, Hui, Hon C., Kim, Choung U., Markevitch, David Y., Vela, Jennifer, Ray, Adrian, Cihlar, Tomas
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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ANTIVIRAL COMPOUNDS
CHUN BYOUNG-KWON, GREGORY F CHIN, BINDU GOYAL, HON C HUI, PETR JANSA, MACKMAN RICHARD L, DUSTIN S SIEGEL, YANG HAI, MICHAEL O CLARKE
Year of Publication 01.02.2024
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Year of Publication 01.02.2024
Patent
Exploiting Subsite S1 of Trypsin-Like Serine Proteases for Selectivity: Potent and Selective Inhibitors of Urokinase-Type Plasminogen Activator
Mackman, Richard L, Katz, Bradley A, Breitenbucher, J. Guy, Hui, Hon C, Verner, Erik, Luong, Christine, Liu, Liang, Sprengeler, Paul A
Published in Journal of medicinal chemistry (08.11.2001)
Published in Journal of medicinal chemistry (08.11.2001)
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Journal Article
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors
Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.
Published in Journal of molecular biology (23.05.2003)
Published in Journal of molecular biology (23.05.2003)
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Journal Article
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo(2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C., Doerffler, Edward, Clarke, Michael O., Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M., Barauskas, Ona, Feng, Joy Y., Xu, Yili, Lee, Gary, Rheingold, Arnold L., Ray, Adrian S., Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A., Bavari, Sina, Cihlar, Tomas, Lo, Michael K., Warren, Travis K., Mackman, Richard L.
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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A general and efficient solid phase synthesis of quinazoline-2,4-diones
Gordeev, Mikhail F, Hui, Hon C, Gordon, Eric M, Patel, Dinesh V
Published in Tetrahedron letters (10.03.1997)
Published in Tetrahedron letters (10.03.1997)
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Journal Article
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina
Published in Nature (London) (17.03.2016)
Published in Nature (London) (17.03.2016)
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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors
MACKMAN, Richard L, HUI, Hon C, SPRENGELER, Paul A, TARIO, James, VERNER, Erik, JING WANG, BREITENBUCHER, J. Guy, KATZ, Bradley A, LUONG, Christine, MARTELLI, Arnold, MCGEE, Danny, RADIKA, Kesavan, SENDZIK, Martin, SPENCER, Jeffrey R
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
Published in Bioorganic & medicinal chemistry letters (05.08.2002)
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Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis
Lyttle, Matthew H, Hocker, Michael D, Hui, Hon C, Caldwell, Colby G, Aaron, Decius T, Engqvist-Goldstein, Asa, Flatgaard, Jeffrey E, Bauer, Karin E
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Glutathione-S-transferase Activates Novel Alkylating Agents
Lyttle, Matthew H, Satyam, Apparao, Hocker, Michael D, Bauer, Karin E, Caldwell, Colby G, Hui, Hon C, Morgan, Amy S, Mergia, Alemayehu, Kauvar, Lawrence M
Published in Journal of medicinal chemistry (01.05.1994)
Published in Journal of medicinal chemistry (01.05.1994)
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Modulators of pharmacokinetic properties of therapeutics
Desai Manoj C, Hui Hon C, Vivian Radall W, Xu Lianhong, Hong Allen Y, Liu Hongtao
Year of Publication 31.07.2024
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Year of Publication 31.07.2024
Patent
MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
Liu, Hongtao, Desai, Manoj, C, Xu, Lianhong, Vivian, Radall W, Hui, Hon C, Hong, Allen Y
Year of Publication 05.07.2024
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Year of Publication 05.07.2024
Patent