Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides
Kol, Matthijs, Williams, Ben, Toombs-Ruane, Henry, Franquelim, Henri G, Korneev, Sergei, Schroeer, Christian, Schwille, Petra, Trauner, Dirk, Holthuis, Joost Cm, Frank, James A
Published in eLife (05.02.2019)
Published in eLife (05.02.2019)
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Journal Article
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Sokoya, Tolulope, Parolek, Jan, Foged, Mads Møller, Danylchuk, Dmytro I, Bozan, Manuel, Sarkar, Bingshati, Hilderink, Angelika, Philippi, Michael, Botto, Lorenzo D, Terhal, Paulien A, Mäkitie, Outi, Piehler, Jacob, Kim, Yeongho, Burd, Christopher G, Klymchenko, Andrey S, Maeda, Kenji, Holthuis, Joost C M
Published in eLife (14.09.2022)
Published in eLife (14.09.2022)
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Journal Article
On the origin of lipid asymmetry: the flip side of ion transport
Lenoir, Guillaume, Williamson, Patrick, Holthuis, Joost CM
Published in Current opinion in chemical biology (01.12.2007)
Published in Current opinion in chemical biology (01.12.2007)
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Journal Article
InVivo Profiling and Visualization of Cellular Protein-Lipid Interactions Using Bifunctional Fatty Acids
Haberkant, Per, Raijmakers, Reinout, Wildwater, Marjolein, Sachsenheimer, Timo, Bruegger, Britta, Maeda, Kenji, Houweling, Martin, Gavin, Anne-Claude, Schultz, Carsten, van Meer, Gerrit, Heck, Albert J. R., Holthuis, Joost C. M.
Published in Angewandte Chemie International Edition (02.04.2013)
Published in Angewandte Chemie International Edition (02.04.2013)
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Journal Article
Identification of a family of animal sphingomyelin synthases
Huitema, Klazien, van den Dikkenberg, Joep, Brouwers, Jos FHM, Holthuis, Joost CM
Published in The EMBO journal (14.01.2004)
Published in The EMBO journal (14.01.2004)
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Journal Article
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
Vacaru, Ana M, Tafesse, Fikadu G, Ternes, Philipp, Kondylis, Vangelis, Hermansson, Martin, Brouwers, Jos F.H.M, Somerharju, Pentti, Rabouille, Catherine, Holthuis, Joost C.M
Published in The Journal of cell biology (15.06.2009)
Published in The Journal of cell biology (15.06.2009)
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Journal Article
Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells
Tafesse, Fikadu Geta, Huitema, Klazien, Hermansson, Martin, van der Poel, Seleéne, van den Dikkenberg, Joep, Uphoff, Andreas, Somerharju, Pentti, Holthuis, Joost C.M.
Published in The Journal of biological chemistry (15.06.2007)
Published in The Journal of biological chemistry (15.06.2007)
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Journal Article
Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases
Kol, Matthijs, Panatala, Radhakrishnan, Nordmann, Mirjana, Swart, Leoni, van Suijlekom, Leonie, Cabukusta, Birol, Hilderink, Angelika, Grabietz, Tanja, Mina, John G.M., Somerharju, Pentti, Korneev, Sergei, Tafesse, Fikadu G., Holthuis, Joost C.M.
Published in Journal of lipid research (01.05.2017)
Published in Journal of lipid research (01.05.2017)
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Journal Article
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis
Pomorski, Thomas, Lombardi, Ruben, Riezman, Howard, Devaux, Philippe F, van Meer, Gerrit, Holthuis, Joost C M
Published in Molecular biology of the cell (01.03.2003)
Published in Molecular biology of the cell (01.03.2003)
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Journal Article
Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles
Alder-Baerens, Nele, Lisman, Quirine, Luong, Lambert, Pomorski, Thomas, Holthuis, Joost C M
Published in Molecular biology of the cell (01.04.2006)
Published in Molecular biology of the cell (01.04.2006)
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Journal Article
Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
Pekkinen, Minna, Terhal, Paulien A, Botto, Lorenzo D, Henning, Petra, Mäkitie, Riikka E, Roschger, Paul, Jain, Amrita, Kol, Matthijs, Kjellberg, Matti A, Paschalis, Eleftherios P, van Gassen, Koen, Murray, Mary, Bayrak-Toydemir, Pinar, Magnusson, Maria K, Jans, Judith, Kausar, Mehran, Carey, John C, Somerharju, Pentti, Lerner, Ulf H, Olkkonen, Vesa M, Klaushofer, Klaus, Holthuis, Joost Cm, Mäkitie, Outi
Published in JCI insight (04.04.2019)
Published in JCI insight (04.04.2019)
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Journal Article
Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases
Kol, Matthijs, Panatala, Radhakrishnan, Nordmann, Mirjana, Swart, Leoni, van Suijlekom, Leonie, Cabukusta, Birol, Hilderink, Angelika, Grabietz, Tanja, Mina, John G.M., Somerharju, Pentti, Korneev, Sergei, Tafesse, Fikadu G., Holthuis, Joost C.M.
Published in Journal of lipid research (01.07.2016)
Published in Journal of lipid research (01.07.2016)
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Journal Article
Folding defects in P‐type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4‐phenylbutyrate
van der Velden, Lieke M., Stapelbroek, Janneke M., Krieger, Elmar, van den Berghe, Peter V. E., Berger, Ruud, Verhulst, Patricia M., Holthuis, Joost C. M., Houwen, Roderick H. J., Klomp, Leo W. J., van de Graaf, Stan F. J.
Published in Hepatology (Baltimore, Md.) (01.01.2010)
Published in Hepatology (Baltimore, Md.) (01.01.2010)
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Journal Article
The CLN9 Protein, a Regulator of Dihydroceramide Synthase
Schulz, Angela, Mousallem, Talal, Venkataramani, Maya, Persaud-Sawin, Dixie-Ann, Zucker, Adam, Luberto, Chiara, Bielawska, Alicja, Bielawski, Jacek, Holthuis, Joost C.M., Jazwinski, S. Michal, Kozhaya, Lina, Dbaibo, Ghassan S., Boustany, Rose-Mary N.
Published in The Journal of biological chemistry (03.02.2006)
Published in The Journal of biological chemistry (03.02.2006)
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Journal Article
Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
Pekkinen, Minna, Terhal, Paulien A., Botto, Lorenzo D., Henning, Petra, Mäkitie, Riikka E., Roschger, Paul, Jain, Amrita, Kol, Matthijs, Kjellberg, Matti A., Paschalis, Eleftherios P., van Gassen, Koen, Murray, Mary, Bayrak-Toydemir, Pinar, Magnusson, Maria K., Jans, Judith, Kausar, Mehran, Carey, John C., Somerharju, Pentti, Lerner, Ulf H., Olkkonen, Vesa M., Klaushofer, Klaus, Holthuis, Joost C.M., Mäkitie, Outi
Published in JCI insight (04.04.2019)
Published in JCI insight (04.04.2019)
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Journal Article
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Sokoya, Tolulope, Parolek, Jan, Mads Moeller Foged, Danylchuk, Dmytro I, Bozan, Manuel, Sarkar, Bingshati, Hilderink, Angelika, Philippi, Michael, Botto, Lorenzo D, Terhal, Paulien A, Maekitie, Outi, Piehler, Jacob, Kim, Yeongho, Burd, Christopher G, Klymchenko, Andrey S, Maeda, Kenji, Joost Cm Holthuis
Published in bioRxiv (03.04.2022)
Published in bioRxiv (03.04.2022)
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