Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated
Varshneya, Neil B., Hassanien, Sherif H., Holt, Melissa C., Stevens, David L., Layle, Nathan K., Bassman, Jonathon R., Iula, Donna M., Beardsley, Patrick M.
Published in Biochemical pharmacology (01.01.2022)
Published in Biochemical pharmacology (01.01.2022)
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Journal Article
Improved homology modeling of the human & rat EP4 prostanoid receptors
Holt, Melissa C., Ho, Chi S., Morano, M. Inés, Barrett, Stephen D., Stein, Adam J.
Published in BMC cell biology (27.08.2019)
Published in BMC cell biology (27.08.2019)
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Journal Article
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression
Varshneya, Neil B., Hassanien, Sherif H., Holt, Melissa C., Stevens, David L., Layle, Nathan K., Bassman, Jonathon R., Iula, Donna M., Beardsley, Patrick M.
Published in Pharmacology, biochemistry and behavior (01.05.2023)
Published in Pharmacology, biochemistry and behavior (01.05.2023)
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Journal Article
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors
Holt, Melissa C, Assar, Zahra, Beheshti Zavareh, Reza, Lin, Lin, Anglin, Justin, Mashadova, Oksana, Haldar, Daniel, Mullarky, Edouard, Kremer, Daniel M, Cantley, Lewis C, Kimmelman, Alec C, Stein, Adam J, Lairson, Luke L, Lyssiotis, Costas A
Published in Biochemistry (Easton) (27.11.2018)
Published in Biochemistry (Easton) (27.11.2018)
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Journal Article
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety
Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.
Published in ChemMedChem (20.08.2019)
Published in ChemMedChem (20.08.2019)
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Journal Article
Difluoromethylene at the γ‑Lactam α‑Position Improves 11-Deoxy-8-aza-PGE1 Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE1 Analog (KMN-159) as a Potent EP4 Agonist
Barrett, Stephen D, Holt, Melissa C, Kramer, James B, Germain, Bradlee, Ho, Chi S, Ciske, Fred L, Kornilov, Andrei, Colombo, Joseph M, Uzieblo, Adam, O’Malley, James P, Owen, Thomas A, Stein, Adam J, Morano, Maria I
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Novel amide and imidazole compounds as potent hematopoietic prostaglandin D-2 synthase inhibitors
Olson, Kirk L., Holt, Melissa C., Ciske, Fred L., Kramer, James B., Heiple, Paige E., Collins, Margaret L., Johnson, Carrie M., Ho, Chi S., Morano, M. Ines, Barrett, Stephen D.
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
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Journal Article
Novel amide and imidazole compounds as potent hematopoietic prostaglandin D2 synthase inhibitors
Olson, Kirk L., Holt, Melissa C., Ciske, Fred L., Kramer, James B., Heiple, Paige E., Collins, Margaret L., Johnson, Carrie M., Ho, Chi S., Morano, M. Ines, Barrett, Stephen D.
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
Published in Bioorganic & medicinal chemistry letters (15.02.2021)
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Journal Article
Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE 1 Series EP 4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE 1 Analog (KMN-159) as a Potent EP 4 Agonist
Barrett, Stephen D, Holt, Melissa C, Kramer, James B, Germain, Bradlee, Ho, Chi S, Ciske, Fred L, Kornilov, Andrei, Colombo, Joseph M, Uzieblo, Adam, O'Malley, James P, Owen, Thomas A, Stein, Adam J, Morano, Maria I
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
A Novel Glucose 6-Phosphate Isomerase from Listeria monocytogenes
Cech, David L., Wang, Pan-Fen, Holt, Melissa C., Assimon, Victoria A., Schaub, Jeffrey M., Holler, Tod P., Woodard, Ronald W.
Published in Protein Journal (01.10.2014)
Published in Protein Journal (01.10.2014)
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Journal Article
Difluoromethylene at the gamma-Lactam alpha-Position Improves 11-Deoxy-8-aza-PGE(1) Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE(1) Analog (KMN-159) as a Potent EP4 Agonist
Barrett, Stephen D., Holt, Melissa C., Kramer, James B., Germain, Bradlee, Ho, Chi S., Ciske, Fred L., Kornilov, Andrei, Colombo, Joseph M., Uzieblo, Adam, O'Malley, James P., Owen, Thomas A., Stein, Adam J., Morano, Maria I.
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Improved homology modeling of the human & rat EP 4 prostanoid receptors
Holt, Melissa C, Ho, Chi S, Morano, M Inés, Barrett, Stephen D, Stein, Adam J
Published in BMC molecular and cell biology (27.08.2019)
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Published in BMC molecular and cell biology (27.08.2019)
Journal Article