Minimizing the damage: repair pathways keep mitochondrial DNA intact
Kazak, Lawrence, Reyes, Aurelio, Holt, Ian J.
Published in Nature reviews. Molecular cell biology (01.10.2012)
Published in Nature reviews. Molecular cell biology (01.10.2012)
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PrimPol, an Archaic Primase/Polymerase Operating in Human Cells
García-Gómez, Sara, Reyes, Aurelio, Martínez-Jiménez, María I, Chocrón, E. Sandra, Mourón, Silvana, Terrados, Gloria, Powell, Christopher, Salido, Eduardo, Méndez, Juan, Holt, Ian J, Blanco, Luis
Published in Molecular cell (21.11.2013)
Published in Molecular cell (21.11.2013)
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Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development
Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.
Published in Cell (25.05.2012)
Published in Cell (25.05.2012)
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Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication
Holmes, J. Bradley, Gokhan Akman, Stuart R. Wood, Kiran Sakhuja, Susana M. Cerritelli, Chloe Moss, Mark R. Bowmaker, Howard T. Jacobs, Robert J. Crouch, Ian J. Holt
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (28.07.2015)
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Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure
Gerhold, Joachim M., Cansiz-Arda, Şirin, Lõhmus, Madis, Engberg, Oskar, Reyes, Aurelio, van Rennes, Helga, Sanz, Alberto, Holt, Ian J., Cooper, Helen M., Spelbrink, Johannes N.
Published in Scientific reports (19.10.2015)
Published in Scientific reports (19.10.2015)
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TEFM (c17orf42) is necessary for transcription of human mtDNA
Minczuk, Michal, He, Jiuya, Duch, Anna M, Ettema, Thijs J, Chlebowski, Aleksander, Dzionek, Karol, Nijtmans, Leo G J, Huynen, Martijn A, Holt, Ian J
Published in Nucleic acids research (01.05.2011)
Published in Nucleic acids research (01.05.2011)
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Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model
Moss, Chloe F, Dalla Rosa, Ilaria, Hunt, Lilian E, Yasukawa, Takehiro, Young, Robert, Jones, Aleck W E, Reddy, Kaalak, Desai, Radha, Virtue, Sam, Elgar, Greg, Voshol, Peter, Taylor, Martin S, Holt, Ian J, Reijns, Martin A M, Spinazzola, Antonella
Published in Nucleic acids research (15.12.2017)
Published in Nucleic acids research (15.12.2017)
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Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis
Johnson, Mark A, Vidoni, Sara, Durigon, Romina, Pearce, Sarah F, Rorbach, Joanna, He, Jiuya, Brea-Calvo, Gloria, Minczuk, Michal, Reyes, Aurelio, Holt, Ian J, Spinazzola, Antonella
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA
Pantic, Boris, Ives, Daniel, Mennuni, Mara, Perez-Rodriguez, Diego, Fernandez-Pelayo, Uxoa, Lopez de Arbina, Amaia, Muñoz-Oreja, Mikel, Villar-Fernandez, Marina, Dang, Thanh-mai Julie, Vergani, Lodovica, Johnston, Iain G., Pitceathly, Robert D. S., McFarland, Robert, Hanna, Michael G., Taylor, Robert W., Holt, Ian J., Spinazzola, Antonella
Published in Nature communications (06.12.2021)
Published in Nature communications (06.12.2021)
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MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria
Dalla Rosa, Ilaria, Cámara, Yolanda, Durigon, Romina, Moss, Chloe F, Vidoni, Sara, Akman, Gokhan, Hunt, Lilian, Johnson, Mark A, Grocott, Sarah, Wang, Liya, Thorburn, David R, Hirano, Michio, Poulton, Joanna, Taylor, Robert W, Elgar, Greg, Martí, Ramon, Voshol, Peter, Holt, Ian J, Spinazzola, Antonella
Published in PLoS genetics (01.01.2016)
Published in PLoS genetics (01.01.2016)
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Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria
Akman, Gokhan, Desai, Radha, Bailey, Laura J., Yasukawa, Takehiro, Rosa, Ilaria Dalla, Durigon, Romina, Holmes, J. Bradley, Moss, Chloe F., Mennuni, Mara, Houlden, Henry, Crouch, Robert J., Hanna, Michael G., Pitceathly, Robert D. S., Spinazzola, Antonella, Holt, Ian J.
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
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Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication
Fusté, Javier Miralles, Wanrooij, Sjoerd, Jemt, Elisabeth, Granycome, Caroline E., Cluett, Tricia J., Shi, Yonghong, Atanassova, Neli, Holt, Ian J., Gustafsson, Claes M., Falkenberg, Maria
Published in Molecular cell (2010)
Published in Molecular cell (2010)
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2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart
Aiestaran-Zelaia, Irati, Sánchez-Guisado, María Jesús, Villar-Fernandez, Marina, Azkargorta, Mikel, Fadon-Padilla, Lucia, Fernandez-Pelayo, Uxoa, Perez-Rodriguez, Diego, Ramos-Cabrer, Pedro, Spinazzola, Antonella, Elortza, Félix, Ruíz-Cabello, Jésus, Holt, Ian J.
Published in Scientific reports (27.04.2022)
Published in Scientific reports (27.04.2022)
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Journal Article
MPV17L2 is required for ribosome assembly in mitochondria
Dalla Rosa, Ilaria, Durigon, Romina, Pearce, Sarah F, Rorbach, Joanna, Hirst, Elizabeth M A, Vidoni, Sara, Reyes, Aurelio, Brea-Calvo, Gloria, Minczuk, Michal, Woellhaf, Michael W, Herrmann, Johannes M, Huynen, Martijn A, Holt, Ian J, Spinazzola, Antonella
Published in Nucleic acids research (29.07.2014)
Published in Nucleic acids research (29.07.2014)
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Journal Article
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand
Yasukawa, Takehiro, Reyes, Aurelio, Cluett, Tricia J, Yang, Ming-Yao, Bowmaker, Mark, Jacobs, Howard T, Holt, Ian J
Published in The EMBO journal (15.11.2006)
Published in The EMBO journal (15.11.2006)
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LETM1 couples mitochondrial DNA metabolism and nutrient preference
Durigon, Romina, Mitchell, Alice L, Jones, Aleck WE, Manole, Andreea, Mennuni, Mara, Hirst, Elizabeth MA, Houlden, Henry, Maragni, Giuseppe, Lattante, Serena, Doronzio, Paolo Niccolo’, Dalla Rosa, Ilaria, Zollino, Marcella, Holt, Ian J, Spinazzola, Antonella
Published in EMBO molecular medicine (01.09.2018)
Published in EMBO molecular medicine (01.09.2018)
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Journal Article
Alternative translation initiation augments the human mitochondrial proteome
Kazak, Lawrence, Reyes, Aurelio, Duncan, Anna L, Rorbach, Joanna, Wood, Stuart R, Brea-Calvo, Gloria, Gammage, Payam A, Robinson, Alan J, Minczuk, Michal, Holt, Ian J
Published in Nucleic acids research (01.02.2013)
Published in Nucleic acids research (01.02.2013)
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