Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K+ currents in neurons
Vigil, Fabio A, Bozdemir, Eda, Bugay, Vladislav, Chun, Sang H, Hobbs, MaryAnn, Sanchez, Isamar, Hastings, Shayne D, Veraza, Rafael J, Holstein, Deborah M, Sprague, Shane M, M Carver, Chase, Cavazos, Jose E, Brenner, Robert, Lechleiter, James D, Shapiro, Mark S
Published in Journal of cerebral blood flow and metabolism (01.06.2020)
Published in Journal of cerebral blood flow and metabolism (01.06.2020)
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P2Y1R-Initiated, IP3R-Dependent Stimulation of Astrocyte Mitochondrial Metabolism Reduces and Partially Reverses Ischemic Neuronal Damage in Mouse
Zheng, Wei, Watts, Lora Talley, Holstein, Deborah M, Wewer, Jimmy, Lechleiter, James D
Published in Journal of cerebral blood flow and metabolism (01.04.2013)
Published in Journal of cerebral blood flow and metabolism (01.04.2013)
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Calcineurin β protects brain after injury by activating the unfolded protein response
Chen, Yanan, Holstein, Deborah M, Aime, Sofia, Bollo, Mariana, Lechleiter, James D
Published in Neurobiology of disease (01.10.2016)
Published in Neurobiology of disease (01.10.2016)
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Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria
Zheng, Wei, Watts, Lora Talley, Holstein, Deborah M, Prajapati, Suresh I, Keller, Charles, Grass, Eileen H, Walter, Christi A, Lechleiter, James D
Published in PloS one (22.12.2010)
Published in PloS one (22.12.2010)
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Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke
Fisher, Elizabeth S, Chen, Yanan, Sifuentes, Mikaela M, Stubblefield, Jeremy J, Lozano, Damian, Holstein, Deborah M, Ren, JingMei, Davenport, Matthew, DeRosa, Nicholas, Chen, Tsung-Pei, Nickel, Gerard, Liston, Theodore E, Lechleiter, James D
Published in Frontiers in stroke (01.01.2022)
Published in Frontiers in stroke (01.01.2022)
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A Mouse Model of Repetitive Blast Traumatic Brain Injury Reveals Post-Trauma Seizures and Increased Neuronal Excitability
Bugay, Vladislav, Bozdemir, Eda, Vigil, Fabio A, Chun, Sang H, Holstein, Deborah M, Elliott, William R, Sprague, Cassie J, Cavazos, Jose E, Zamora, David O, Rule, Gregory, Shapiro, Mark S, Lechleiter, James D, Brenner, Robert
Published in Journal of neurotrauma (15.01.2020)
Published in Journal of neurotrauma (15.01.2020)
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Acute Treatment with the M-Channel (Kv7, KCNQ) Opener Retigabine Reduces the Long-Term Effects of Repetitive Blast Traumatic Brain Injuries
Vigil, Fabio A., Belchior, Hindiael, Bugay, Vladislav, Bazaldua, Isabella I., Stoja, Aiola, Dantas, Denise C., Chun, Sang H., Farmer, Austin, Bozdemir, Eda, Holstein, Deborah M., Cavazos, Jose E., Lechleiter, James D., Brenner, Robert, Shapiro, Mark S.
Published in Neurotherapeutics (01.04.2023)
Published in Neurotherapeutics (01.04.2023)
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Journal Article
Neuroprotective Roles of the Adenosine A3 Receptor Agonist AST-004 in Mouse Model of Traumatic Brain Injury
Bozdemir, Eda, Vigil, Fabio A., Chun, Sang H., Espinoza, Liliana, Bugay, Vladislav, Khoury, Sarah M., Holstein, Deborah M., Stoja, Aiola, Lozano, Damian, Tunca, Ceyda, Sprague, Shane M., Cavazos, Jose E., Brenner, Robert, Liston, Theodore E., Shapiro, Mark S., Lechleiter, James D.
Published in Neurotherapeutics (01.10.2021)
Published in Neurotherapeutics (01.10.2021)
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Journal Article
Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology
Liston, Theodore E., Hinz, Sonja, Müller, Christa E., Holstein, Deborah M., Wendling, Jay, Melton, Roger J., Campbell, Mary, Korinek, William S., Suresh, R. Rama, Sethre-Hofstad, Dane A., Gao, Zhan-Guo, Tosh, Dilip K., Jacobson, Kenneth A., Lechleiter, James D.
Published in Purinergic signalling (01.12.2020)
Published in Purinergic signalling (01.12.2020)
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Journal Article
Corrigendum: Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke
Fisher, Elizabeth S., Chen, Yanan, Sifuentes, Mikaela M., Stubblefield, Jeremy J., Lozano, Damian, Holstein, Deborah M., Ren, JingMei, Davenport, Matthew, DeRosa, Nicholas, Chen, Tsung-pei, Nickel, Gerard, Liston, Theodore E., Lechleiter, James D.
Published in Frontiers in stroke (29.01.2024)
Published in Frontiers in stroke (29.01.2024)
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Journal Article
Novel Drugs that Augment KCNQ (KV7, “M-Type”) Potassium Channels as a Post-Event Treatment for Traumatic Brain Injury
Sanchez, Isamar, Antonio, Fabio, Vigil, Borges, Bozdemir, Eda, Veraza, Rafael J., Espinoza, Liliana, Holstein, Deborah M., Hobbs, MaryAnn, Bugay, Vladislav, Lechleiter, James, Brenner, Robert, Shapiro, Mark S.
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Journal Article
P2Y sub(1)R-initiated, IP sub(3)R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse
Zheng, Wei, Talley Watts, Lora, Holstein, Deborah M, Wewer, Jimmy, Lechleiter, James D
Published in Journal of cerebral blood flow and metabolism (01.04.2013)
Published in Journal of cerebral blood flow and metabolism (01.04.2013)
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Journal Article
P2Y 1 R-Initiated, IP 3 R-Dependent Stimulation of Astrocyte Mitochondrial Metabolism Reduces and Partially Reverses Ischemic Neuronal Damage in Mouse
Zheng, Wei, Watts, Lora Talley, Holstein, Deborah M, Wewer, Jimmy, Lechleiter, James D
Published in Journal of cerebral blood flow and metabolism (16.01.2013)
Published in Journal of cerebral blood flow and metabolism (16.01.2013)
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Journal Article
Neuroprotective Roles of the Adenosine A 3 Receptor Agonist AST-004 in Mouse Model of Traumatic Brain Injury
Bozdemir, Eda, Vigil, Fabio A, Chun, Sang H, Espinoza, Liliana, Bugay, Vladislav, Khoury, Sarah M, Holstein, Deborah M, Stoja, Aiola, Lozano, Damian, Tunca, Ceyda, Sprague, Shane M, Cavazos, Jose E, Brenner, Robert, Liston, Theodore E, Shapiro, Mark S, Lechleiter, James D
Published in Neurotherapeutics (01.10.2021)
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Published in Neurotherapeutics (01.10.2021)
Journal Article
Nucleotide P2Y 1 receptor agonists are in vitro and in vivo prodrugs of A 1 /A 3 adenosine receptor agonists: implications for roles of P2Y 1 and A 1 /A 3 receptors in physiology and pathology
Liston, Theodore E, Hinz, Sonja, Müller, Christa E, Holstein, Deborah M, Wendling, Jay, Melton, Roger J, Campbell, Mary, Korinek, William S, Suresh, R Rama, Sethre-Hofstad, Dane A, Gao, Zhan-Guo, Tosh, Dilip K, Jacobson, Kenneth A, Lechleiter, James D
Published in Purinergic signalling (01.12.2020)
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Published in Purinergic signalling (01.12.2020)
Journal Article
Calcium-sensing Receptor-mediated ERK1/2 Activation Requires Gαi2 Coupling and Dynamin-independent Receptor Internalization
Holstein, Deborah M., Berg, Kelly A., Leeb-Lundberg, L.M. Fredrik, Olson, Merle S., Saunders, Christine
Published in The Journal of biological chemistry (12.03.2004)
Published in The Journal of biological chemistry (12.03.2004)
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Journal Article
Calcium-sensing receptor-mediated ERK1/2 activation requires Galphai2 coupling and dynamin-independent receptor internalization
Holstein, Deborah M, Berg, Kelly A, Leeb-Lundberg, L M Fredrik, Olson, Merle S, Saunders, Christine
Published in The Journal of biological chemistry (12.03.2004)
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Published in The Journal of biological chemistry (12.03.2004)
Journal Article
Calcium-sensing Receptor-mediated ERK1/2 Activation Requires Gαi2 Coupling and Dynamin-independent Receptor Internalization
Deborah M. Holstein, Kelly A. Berg, L. M. Fredrik Leeb-Lundberg, Merle S. Olson, Christine Saunders
Published in The Journal of biological chemistry (12.03.2004)
Published in The Journal of biological chemistry (12.03.2004)
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Journal Article
Adenosine A1R/A3R Agonist AST-004 Reduces Brain Infarction in Mouse and Rat Models of Acute Ischemic Stroke
Fisher, Elizabeth S, Chen, Yanan, Sifuentes, Mikaela M, Stubblefield, Jeremy J, Lozano, Damian, Holstein, Deborah M, Ren, Jingmei, Derosa, Nicholas, Chen, Tsung-Pei, Nickel, Gerard, Liston, Theodore E, Lechleiter, James D
Published in bioRxiv (17.03.2022)
Published in bioRxiv (17.03.2022)
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