Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine‐gingipain inhibitor COR388
Arastu‐Kapur, Shirin, Nguyen, Mai, Raha, Debasish, Ermini, Florian, Haditsch, Ursula, Araujo, Joseph, De Lannoy, Ines A. M., Ryder, Mark I., Dominy, Stephen S., Lynch, Casey, Holsinger, Leslie J.
Published in Pharmacology research & perspectives (01.02.2020)
Published in Pharmacology research & perspectives (01.02.2020)
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Journal Article
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
Dominy, Stephen S, Lynch, Casey, Ermini, Florian, Benedyk, Malgorzata, Marczyk, Agata, Konradi, Andrei, Nguyen, Mai, Haditsch, Ursula, Raha, Debasish, Griffin, Christina, Holsinger, Leslie J, Arastu-Kapur, Shirin, Kaba, Samer, Lee, Alexander, Ryder, Mark I, Potempa, Barbara, Mydel, Piotr, Hellvard, Annelie, Adamowicz, Karina, Hasturk, Hatice, Walker, Glenn D, Reynolds, Eric C, Faull, Richard L M, Curtis, Maurice A, Dragunow, Mike, Potempa, Jan
Published in Science advances (01.01.2019)
Published in Science advances (01.01.2019)
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Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains
Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Hancock, Sandy, Cecere, Thomas, Nguyen, Mai, Arastu-Kapur, Shirin, Broce, Sean, Raha, Debasish, Lynch, Casey C, Holsinger, Leslie J, Dominy, Stephen S, Ermini, Florian
Published in Journal of Alzheimer's disease (01.01.2020)
Published in Journal of Alzheimer's disease (01.01.2020)
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Journal Article
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S
Sevenich, Lisa, Bowman, Robert L, Mason, Steven D, Quail, Daniela F, Rapaport, Franck, Elie, Benelita T, Brogi, Edi, Brastianos, Priscilla K, Hahn, William C, Holsinger, Leslie J, Massagué, Joan, Leslie, Christina S, Joyce, Johanna A
Published in Nature cell biology (01.09.2014)
Published in Nature cell biology (01.09.2014)
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Journal Article
The Minimal Essential Core of a Cysteine-based Protein-tyrosine Phosphatase Revealed by a Novel 16-kDa VH1-like Phosphatase, VHZ
Alonso, Andres, Burkhalter, Stephen, Sasin, Joanna, Tautz, Lutz, Bogetz, Jori, Huynh, Huong, Bremer, Meire C D, Holsinger, Leslie J, Godzik, Adam, Mustelin, Tomas
Published in The Journal of biological chemistry (20.08.2004)
Published in The Journal of biological chemistry (20.08.2004)
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Journal Article
Increased levels of phospho‐tau217 in neuron cultures and CVN mice infected with Porphyromonas gingivalis
Ermini, Florian, Haditsch, Ursula, Rodriguez, Leo, Martinez‐Horta, Aurora, Broce, Sean, Raha, Debasish, Nguyen, Mai, Kapur, Shirin, Lynch, Casey C, Holsinger, Leslie J, Dominy, Stephen S
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model
Elie, Benelita Tina, Gocheva, Vasilena, Shree, Tanaya, Dalrymple, Stacie A., Holsinger, Leslie J., Joyce, Johanna A.
Published in Biochimie (01.11.2010)
Published in Biochimie (01.11.2010)
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Journal Article
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)
Holsinger, Leslie J, Ward, Kevin, Duffield, Bill, Zachwieja, Joseph, Jallal, Bahija
Published in Oncogene (10.10.2002)
Published in Oncogene (10.10.2002)
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Journal Article
VHY, a Novel Myristoylated Testis-restricted Dual Specificity Protein Phosphatase Related to VHX
Alonso, Andres, Narisawa, Sonoko, Bogetz, Jori, Tautz, Lutz, Hadzic, Radinka, Huynh, Huong, Williams, Scott, Gjörloff-Wingren, Anette, Bremer, Meire C D, Holsinger, Leslie J, Millan, José L, Mustelin, Tomas
Published in The Journal of biological chemistry (30.07.2004)
Published in The Journal of biological chemistry (30.07.2004)
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Journal Article
리신 진지파인의 케톤 억제제
DOMINY STEPHEN S, KONRADI ANDREI W, GALEMMO ROBERT A. JR, HOLSINGER LESLIE J, LYNCH CASEY C
Year of Publication 25.06.2019
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Year of Publication 25.06.2019
Patent
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70
Graef, Isabella A., Holsinger, Leslie J., Diver, Steve, Schreiber, Stuart L., Crabtree, Gerald R.
Published in The EMBO journal (15.09.1997)
Published in The EMBO journal (15.09.1997)
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Journal Article
Phase 2 Study Design and New Data from the Phase 1 SAD/MAD Trial of LHP588, A Second‐Generation Gingipain Inhibitor for the Treatment of P. Gingivalis ‐ Positive Alzheimer Dementia
Detke, Michael, Sabbagh, Marwan, Holsinger, Leslie J, Bolger, Joanna, Wang, Jianhong, Ryder, Mark, Hendrix, Suzanne B., Dickson, Samuel P., Mallinckrodt, Craig, Lynch, Casey C, Dominy, Stephen S
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients
Raha, Debasish, Broce, Sean, Haditsch, Ursula, Rodriguez, Leo, Ermini, Florian, Detke, Mike, Kapur, Shirin, Hennings, Dave, Roth, Theresa, Nguyen, Mai, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
COR388, a novel gingipain inhibitor, decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients: Human/Human trials: Other
Raha, Debasish, Broce, Sean, Haditsch, Ursula, Rodriguez, Leo, Ermini, Florian, Detke, Mike, Kapur, Shirin, Hennings, Dave, Roth, Theresa, Nguyen, Mai, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Abstract 3217: Discovery of novel inhibitors of the epigenetic regulator Kat6a histone acetyl transferase and characterization of their anti-tumor activity
Holsinger, Leslie J., Rai, Roopa, Nagawade, Rahul R., Pal, Benoy K., Pawar, Samir G., Putta, Krishna Anand, S.C., Somashekar, Jaleel, Mahaboobi, Wang, Jianhong, Hannah, Alison L.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Comprehensive Alzheimer’s pathology is induced by P. gingivalis infection: COR388 and other gingipain inhibitors protect against synaptic loss
Ermini, Florian, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Hancock, Sandy, Cecere, Thomas, Detke, Mike, Kapur, Shirin, Holsinger, Leslie J., Lynch, Casey C., Dominy, Steve
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Targeting porphyromonas gingivalis to treat Alzheimer’s disease and comorbid cardiovascular disease: Developing topics
Ermini, Florian, Rojas, Paola, Dean, Afsah, Stephens, Danielle, Patel, Michele, Haditsch, Ursula, Roth, Theresa, Rodriguez, Leo, Broce, Sean, Raha, Debasish, Nguyen, Mai, Kapur, Shirin, Lynch, Casey C, Dominy, Stephen S, Holsinger, Leslie J, Hasturk, Hatice
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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