Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner
Holmgaard, Rikke B., Zamarin, Dmitriy, Li, Yanyun, Gasmi, Billel, Munn, David H., Allison, James P., Merghoub, Taha, Wolchok, Jedd D.
Published in Cell reports (Cambridge) (13.10.2015)
Published in Cell reports (Cambridge) (13.10.2015)
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Journal Article
Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
Zamarin, Dmitriy, Holmgaard, Rikke B, Subudhi, Sumit K, Park, Joon Seok, Mansour, Mena, Palese, Peter, Merghoub, Taha, Wolchok, Jedd D, Allison, James P
Published in Science translational medicine (05.03.2014)
Published in Science translational medicine (05.03.2014)
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Journal Article
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
Zamarin, Dmitriy, Holmgaard, Rikke B., Ricca, Jacob, Plitt, Tamar, Palese, Peter, Sharma, Padmanee, Merghoub, Taha, Wolchok, Jedd D., Allison, James P.
Published in Nature communications (13.02.2017)
Published in Nature communications (13.02.2017)
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Journal Article
Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E
Published in Journal for immunotherapy of cancer (04.06.2018)
Published in Journal for immunotherapy of cancer (04.06.2018)
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Journal Article
Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors
Holmgaard, Rikke B., Zamarin, Dmitriy, Lesokhin, Alexander, Merghoub, Taha, Wolchok, Jedd D.
Published in EBioMedicine (01.04.2016)
Published in EBioMedicine (01.04.2016)
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Journal Article
Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor
Yingling, Jonathan M, McMillen, William T, Yan, Lei, Huang, Huocong, Sawyer, J Scott, Graff, Jeremy, Clawson, David K, Britt, Karen S, Anderson, Bryan D, Beight, Douglas W, Desaiah, Durisala, Lahn, Michael M, Benhadji, Karim A, Lallena, Maria J, Holmgaard, Rikke B, Xu, Xiaohong, Zhang, Faming, Manro, Jason R, Iversen, Philip W, Iyer, Chandrasekar V, Brekken, Rolf A, Kalos, Michael D, Driscoll, Kyla E
Published in Oncotarget (23.01.2018)
Published in Oncotarget (23.01.2018)
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Journal Article
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy
Holmgaard, Rikke B., Brachfeld, Alexandra, Gasmi, Billel, Jones, David R., Mattar, Marissa, Doman, Thompson, Murphy, Mary, Schaer, David, Wolchok, Jedd D., Merghoub, Taha
Published in Oncoimmunology (02.07.2016)
Published in Oncoimmunology (02.07.2016)
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Journal Article
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
Sharma, Madhav D, Shinde, Rahul, McGaha, Tracy L, Huang, Lei, Holmgaard, Rikke B, Wolchok, Jedd D, Mautino, Mario R, Celis, Esteban, Sharpe, Arlene H, Francisco, Loise M, Powell, Jonathan D, Yagita, Hideo, Mellor, Andrew L, Blazar, Bruce R, Munn, David H
Published in Science advances (01.11.2015)
Published in Science advances (01.11.2015)
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Journal Article
The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy
Khalil, Danny N, Budhu, Sadna, Gasmi, Billel, Zappasodi, Roberta, Hirschhorn-Cymerman, Daniel, Plitt, Tamar, De Henau, Olivier, Zamarin, Dmitriy, Holmgaard, Rikke B, Murphy, Judith T, Wolchok, Jedd D, Merghoub, Taha
Published in Advances in cancer research (2015)
Published in Advances in cancer research (2015)
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Journal Article
FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety
Alakhras, Nada S, Qiu, Jiabin, Rocha, Guilherme V, Witcher, Derrick R, Koester, Anja, You, Jinsam, Schaer, David A, Holmgaard, Rikke B, Driscoll, Kyla, Willy, Jeffrey A, Malherbe, Laurent P
Published in mAbs (18.08.2018)
Published in mAbs (18.08.2018)
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Journal Article
The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment
Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.
Published in Science advances (06.11.2015)
Published in Science advances (06.11.2015)
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Journal Article
Targeting the TGF[beta] pathway with galunisertib, a TGF[beta]RI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E
Published in Journal for immunotherapy of cancer (04.06.2018)
Published in Journal for immunotherapy of cancer (04.06.2018)
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Journal Article
Expression of indoleamine 2.3-dioxygenase by tumors induces local and systemic immunosuppressive effects in a murine melanoma model
Holmgaard, Rikke B, Zamarin, Dmitriy, Munn, David H, Merghoub, Taha, Wolchok, Jedd D
Published in Journal for immunotherapy of cancer (06.11.2014)
Published in Journal for immunotherapy of cancer (06.11.2014)
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Journal Article
FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety
Alakhras, Nada S., Qiu, Jiabin, Rocha, Guilherme V., Witcher, Derrick R., Koester, Anja, You, Jinsam, Schaer, David A., Holmgaard, Rikke B., Driscoll, Kyla, Willy, Jeffrey A., Malherbe, Laurent P.
Published in mAbs (18.08.2018)
Published in mAbs (18.08.2018)
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ANTIBODIES AND METHODS OF USE THEREOF
MERGHOUB TAHA, ZAPPASODI ROBERTA, SCHAER DAVID, WILSON NICHOLAS STUART, HOLMGAARD RIKKE B K, MUNDT CORNELIA ANNE, WOLCHOK JEDD DAVID, SHEBANOVA OLGA, RITTER GERD, SAVITSKY DAVID ADAM, CUILLEROT JEAN-MARIE, PROSCURSHIM IGOR, VAN DIJK MARC, FINDEIS MARK ARTHUR
Year of Publication 01.10.2019
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Year of Publication 01.10.2019
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Anti-PD-1 antibodies and methods of use thereof
MERGHOUB TAHA, ZAPPASODI ROBERTA, RITTER GERT, SCHAER DAVID, HOLMGAARD RIKKE B K, SAVITSKY DAVID ADAM, WILSON NICHOLAS STUART, VAN DIJK MARC, MUNDT CORNELIA ANNE, WOLCHOK JEDD DAVID
Year of Publication 20.04.2018
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Year of Publication 20.04.2018
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ANTICUERPOS Y MÉTODOS DE SU UTILIZACIÓN
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Year of Publication 20.03.2019
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Year of Publication 20.03.2019
Patent