Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
Yones, Sara A, Annett, Alva, Stoll, Patricia, Diamanti, Klev, Holmfeldt, Linda, Barrenäs, Carl Fredrik, Meadows, Jennifer R S, Komorowski, Jan
Published in Scientific reports (06.05.2022)
Published in Scientific reports (06.05.2022)
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Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia
Ntziachristos, Panagiotis, Tsirigos, Aristotelis, Welstead, G Grant, Trimarchi, Thomas, Bakogianni, Sofia, Xu, Luyao, Loizou, Evangelia, Holmfeldt, Linda, Strikoudis, Alexandros, King, Bryan, Mullenders, Jasper, Becksfort, Jared, Nedjic, Jelena, Paietta, Elisabeth, Tallman, Martin S, Rowe, Jacob M, Tonon, Giovanni, Satoh, Takashi, Kruidenier, Laurens, Prinjha, Rab, Akira, Shizuo, Van Vlierberghe, Pieter, Ferrando, Adolfo A, Jaenisch, Rudolf, Mullighan, Charles G, Aifantis, Iannis
Published in Nature (London) (23.10.2014)
Published in Nature (London) (23.10.2014)
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The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
Andersson, Anna K, Ma, Jing, Wang, Jianmin, Chen, Xiang, Gedman, Amanda Larson, Dang, Jinjun, Nakitandwe, Joy, Holmfeldt, Linda, Parker, Matthew, Easton, John, Huether, Robert, Kriwacki, Richard, Rusch, Michael, Wu, Gang, Li, Yongjin, Mulder, Heather, Raimondi, Susana, Pounds, Stanley, Kang, Guolian, Shi, Lei, Becksfort, Jared, Gupta, Pankaj, Payne-Turner, Debbie, Vadodaria, Bhavin, Boggs, Kristy, Yergeau, Donald, Manne, Jayanthi, Song, Guangchun, Edmonson, Michael, Nagahawatte, Panduka, Wei, Lei, Cheng, Cheng, Pei, Deqing, Sutton, Rosemary, Venn, Nicola C, Chetcuti, Albert, Rush, Amanda, Catchpoole, Daniel, Heldrup, Jesper, Fioretos, Thoas, Lu, Charles, Ding, Li, Pui, Ching-Hon, Shurtleff, Sheila, Mullighan, Charles G, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Zhang, Jinghui, Downing, James R
Published in Nature genetics (01.04.2015)
Published in Nature genetics (01.04.2015)
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CREBBP mutations in relapsed acute lymphoblastic leukaemia
Mullighan, Charles G, Zhang, Jinghui, Kasper, Lawryn H, Lerach, Stephanie, Payne-Turner, Debbie, Phillips, Letha A, Heatley, Sue L, Holmfeldt, Linda, Collins-Underwood, J. Racquel, Ma, Jing, Buetow, Kenneth H, Pui, Ching-Hon, Baker, Sharyn D, Brindle, Paul K, Downing, James R
Published in Nature (London) (10.03.2011)
Published in Nature (London) (10.03.2011)
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CREST maps somatic structural variation in cancer genomes with base-pair resolution
Wang, Jianmin, Mullighan, Charles G, Easton, John, Roberts, Stefan, Heatley, Sue L, Ma, Jing, Rusch, Michael C, Chen, Ken, Harris, Christopher C, Ding, Li, Holmfeldt, Linda, Payne-Turner, Debbie, Fan, Xian, Wei, Lei, Zhao, David, Obenauer, John C, Naeve, Clayton, Mardis, Elaine R, Wilson, Richard K, Downing, James R, Zhang, Jinghui
Published in Nature methods (01.08.2011)
Published in Nature methods (01.08.2011)
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The genomic landscape of hypodiploid acute lymphoblastic leukemia
Holmfeldt, Linda, Wei, Lei, Diaz-Flores, Ernesto, Walsh, Michael, Zhang, Jinghui, Ding, Li, Payne-Turner, Debbie, Churchman, Michelle, Andersson, Anna, Chen, Shann-Ching, McCastlain, Kelly, Becksfort, Jared, Ma, Jing, Wu, Gang, Patel, Samir N, Heatley, Susan L, Phillips, Letha A, Song, Guangchun, Easton, John, Parker, Matthew, Chen, Xiang, Rusch, Michael, Boggs, Kristy, Vadodaria, Bhavin, Hedlund, Erin, Drenberg, Christina, Baker, Sharyn, Pei, Deqing, Cheng, Cheng, Huether, Robert, Lu, Charles, Fulton, Robert S, Fulton, Lucinda L, Tabib, Yashodhan, Dooling, David J, Ochoa, Kerri, Minden, Mark, Lewis, Ian D, To, L Bik, Marlton, Paula, Roberts, Andrew W, Raca, Gordana, Stock, Wendy, Neale, Geoffrey, Drexler, Hans G, Dickins, Ross A, Ellison, David W, Shurtleff, Sheila A, Pui, Ching-Hon, Ribeiro, Raul C, Devidas, Meenakshi, Carroll, Andrew J, Heerema, Nyla A, Wood, Brent, Borowitz, Michael J, Gastier-Foster, Julie M, Raimondi, Susana C, Mardis, Elaine R, Wilson, Richard K, Downing, James R, Hunger, Stephen P, Loh, Mignon L, Mullighan, Charles G
Published in Nature genetics (01.03.2013)
Published in Nature genetics (01.03.2013)
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NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
Paugh, Steven W, Bonten, Erik J, Savic, Daniel, Ramsey, Laura B, Thierfelder, William E, Gurung, Prajwal, Malireddi, R K Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R, Laudermilk, Lucas T, Panetta, John C, McCorkle, J Robert, Fan, Yiping, Crews, Kristine R, Stocco, Gabriele, Wilkinson, Mark R, Ferreira, Antonio M, Cheng, Cheng, Yang, Wenjian, Karol, Seth E, Fernandez, Christian A, Diouf, Barthelemy, Smith, Colton, Hicks, J Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J, Holmfeldt, Linda, Mullighan, Charles G, den Boer, Monique L, Pieters, Rob, Jeha, Sima, Dunwell, Thomas L, Latif, Farida, Bhojwani, Deepa, Carroll, William L, Pui, Ching-Hon, Myers, Richard M, Guy, R Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V, Evans, William E
Published in Nature genetics (01.06.2015)
Published in Nature genetics (01.06.2015)
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Genomic and Transcriptomic Characterization of Adult and Pediatric Relapsed Acute Myeloid Leukemia Reveals Novel Therapeutic Targets
Stratmann, Svea, Yones, Sara A, Sun, Jitong, Skaftason, Aron, Mayrhofer, Markus, Norgren, Nina, Krogh Herlin, Morten, Eriksson, Anna, Hoglund, Martin, Palle, Josefine, Jahnukainen, Kirsi, Pokrovskaja Tamm, Katja, Cavelier, Lucia, Holmfeldt, Linda
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
Gutierrez, Alejandro, Kentsis, Alex, Sanda, Takaomi, Holmfeldt, Linda, Chen, Shann-Ching, Zhang, Jianhua, Protopopov, Alexei, Chin, Lynda, Dahlberg, Suzanne E., Neuberg, Donna S., Silverman, Lewis B., Winter, Stuart S., Hunger, Stephen P., Sallan, Stephen E., Zha, Shan, Alt, Frederick W., Downing, James R., Mullighan, Charles G., Look, A. Thomas
Published in Blood (13.10.2011)
Published in Blood (13.10.2011)
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Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia
Skou, Anne-Sofie, Juul-Dam, Kristian L., Hansen, Maria, Lausen, Birgitte, Stratmann, Svea, Holmfeldt, Linda, Aggerholm, Anni, Nyvold, Charlotte G., Ommen, Hans B., Hasle, Henrik
Published in The Journal of molecular diagnostics : JMD (01.12.2021)
Published in The Journal of molecular diagnostics : JMD (01.12.2021)
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Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children
Stratmann, Svea, Vesterlund, Mattias, Umer, Husen M, Eshtad, Saeed, Skaftason, Aron, Herlin, Morten Krogh, Sundström, Christer, Eriksson, Anna, Höglund, Martin, Palle, Josefine, Abrahamsson, Jonas, Jahnukainen, Kirsi, Munthe-Kaas, Monica Cheng, Zeller, Bernward, Tamm, Katja Pokrovskaja, Lindskog, Cecilia, Cavelier, Lucia, Lehtiö, Janne, Holmfeldt, Linda
Published in Leukemia (01.03.2023)
Published in Leukemia (01.03.2023)
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CONSERTING: integrating copy-number analysis with structural-variation detection
Chen, Xiang, Gupta, Pankaj, Wang, Jianmin, Nakitandwe, Joy, Roberts, Kathryn, Dalton, James D, Parker, Matthew, Patel, Samir, Holmfeldt, Linda, Payne, Debbie, Easton, John, Ma, Jing, Rusch, Michael, Wu, Gang, Patel, Aman, Baker, Suzanne J, Dyer, Michael A, Shurtleff, Sheila, Espy, Stephen, Pounds, Stanley, Downing, James R, Ellison, David W, Mullighan, Charles G, Zhang, Jinghui
Published in Nature methods (01.06.2015)
Published in Nature methods (01.06.2015)
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Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions
Ryland, Georgina L., Umeda, Masayuki, Holmfeldt, Linda, Lehmann, Sören, Herlin, Morten Krogh, Ma, Jing, Khanlari, Mahsa, Rubnitz, Jeffrey E., Ries, Rhonda E., Kosasih, Hansen J., Ekert, Paul G., Goh, Hwee Ngee, Tiong, Ing S., Grimmond, Sean M., Haferlach, Claudia, Day, Ryan B., Ley, Timothy J., Meshinchi, Soheil, Ma, Xiaotu, Blombery, Piers, Klco, Jeffery M.
Published in Blood (16.02.2023)
Published in Blood (16.02.2023)
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BCL-2, a Therapeutic Target for High Risk Hypodiploid B-Cell Acute Lymphoblastic Leukemia
Diaz-Flores, Ernesto, Comeaux, Evan Q., Kim, Kailyn, Beckman, Kyle, Davis, Kara L., Wu, Kevin, Akutagawa, Jon, Holmfeldt, Linda, Braun, Benjamin S., Mullighan, Charles, Loh, Mignon L.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Cell of origin strongly influences genetic selection in a mouse model of T-ALL
Berquam-Vrieze, Katherine E., Nannapaneni, Kishore, Brett, Benjamin T., Holmfeldt, Linda, Ma, Jing, Zagorodna, Oksana, Jenkins, Nancy A., Copeland, Neal G., Meyerholz, David K., Knudson, C. Michael, Mullighan, Charles G., Scheetz, Todd E., Dupuy, Adam J.
Published in Blood (27.10.2011)
Published in Blood (27.10.2011)
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Abstract 332: Targeting BCL-2 in hypodiploid acute lymphoblastic leukemia
Diaz-Flores, Ernesto, Weng, Julie, Akutagawa, Jon, Holmfeldt, Linda, Chonghaile, Triona, Letai, Anthony, Mullighan, Charles, Braun, Benjamin, Loh, Mignon
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Rare allelic forms of PRDM9 associated with childhood leukemogenesis
Hussin, Julie, Sinnett, Daniel, Casals, Ferran, Idaghdour, Youssef, Bruat, Vanessa, Saillour, Virginie, Healy, Jasmine, Grenier, Jean-Christophe, de Malliard, Thibault, Busche, Stephan, Spinella, Jean-François, Larivière, Mathieu, Gibson, Greg, Andersson, Anna, Holmfeldt, Linda, Ma, Jing, Wei, Lei, Zhang, Jinghui, Andelfinger, Gregor, Downing, James R, Mullighan, Charles G, Awadalla, Philip
Published in Genome research (01.03.2013)
Published in Genome research (01.03.2013)
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