Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
Holmes, Michael V, Ala-Korpela, Mika, Smith, George Davey
Published in Nature reviews cardiology (01.10.2017)
Published in Nature reviews cardiology (01.10.2017)
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Journal Article
Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
Richardson, Tom G, Leyden, Genevieve M, Wang, Qin, Bell, Joshua A, Elsworth, Benjamin, Davey Smith, George, Holmes, Michael V
Published in PLoS biology (25.02.2022)
Published in PLoS biology (25.02.2022)
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Journal Article
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
Richardson, Tom G, Sanderson, Eleanor, Palmer, Tom M, Ala-Korpela, Mika, Ference, Brian A, Davey Smith, George, Holmes, Michael V
Published in PLoS medicine (01.03.2020)
Published in PLoS medicine (01.03.2020)
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Journal Article
Obesity and risk of female reproductive conditions: A Mendelian randomisation study
Venkatesh, Samvida S, Ferreira, Teresa, Benonisdottir, Stefania, Rahmioglu, Nilufer, Becker, Christian M, Granne, Ingrid, Zondervan, Krina T, Holmes, Michael V, Lindgren, Cecilia M, Wittemans, Laura B L
Published in PLoS medicine (01.02.2022)
Published in PLoS medicine (01.02.2022)
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Journal Article
GWAS identifies 14 loci for device-measured physical activity and sleep duration
Doherty, Aiden, Smith-Byrne, Karl, Ferreira, Teresa, Holmes, Michael V, Holmes, Chris, Pulit, Sara L, Lindgren, Cecilia M
Published in Nature communications (10.12.2018)
Published in Nature communications (10.12.2018)
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Journal Article
Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China
Bragg, Fiona, Holmes, Michael V, Iona, Andri, Guo, Yu, Du, Huaidong, Chen, Yiping, Bian, Zheng, Yang, Ling, Herrington, William, Bennett, Derrick, Turnbull, Iain, Liu, Yongmei, Feng, Shixian, Chen, Junshi, Clarke, Robert, Collins, Rory, Peto, Richard, Li, Liming, Chen, Zhengming
Published in JAMA : the journal of the American Medical Association (17.01.2017)
Published in JAMA : the journal of the American Medical Association (17.01.2017)
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Journal Article
Guidelines for performing Mendelian randomization investigations
Burgess, Stephen, Davey Smith, George, Davies, Neil M., Dudbridge, Frank, Gill, Dipender, Glymour, M. Maria, Hartwig, Fernando P., Holmes, Michael V., Minelli, Cosetta, Relton, Caroline L., Theodoratou, Evropi
Published in Wellcome open research (28.04.2020)
Published in Wellcome open research (28.04.2020)
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Journal Article
Causal relationships between obesity and the leading causes of death in women and men
Censin, Jenny C, Peters, Sanne A E, Bovijn, Jonas, Ferreira, Teresa, Pulit, Sara L, Mägi, Reedik, Mahajan, Anubha, Holmes, Michael V, Lindgren, Cecilia M
Published in PLoS genetics (24.10.2019)
Published in PLoS genetics (24.10.2019)
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Journal Article
Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke
Holmes, Michael V., Millwood, Iona Y., Kartsonaki, Christiana, Hill, Michael R., Bennett, Derrick A., Boxall, Ruth, Guo, Yu, Xu, Xin, Bian, Zheng, Hu, Ruying, Walters, Robin G., Chen, Junshi, Ala-Korpela, Mika, Parish, Sarah, Clarke, Robert J., Peto, Richard, Collins, Rory, Li, Liming, Chen, Zhengming
Published in Journal of the American College of Cardiology (13.02.2018)
Published in Journal of the American College of Cardiology (13.02.2018)
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Journal Article
Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
Borges, Maria Carolina, Haycock, Philip C, Zheng, Jie, Hemani, Gibran, Holmes, Michael V, Davey Smith, George, Hingorani, Aroon D, Lawlor, Deborah A
Published in BMC medicine (13.06.2022)
Published in BMC medicine (13.06.2022)
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Journal Article
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D
Published in International journal of epidemiology (01.10.2016)
Published in International journal of epidemiology (01.10.2016)
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Journal Article
Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study
Bell, Joshua A, Carslake, David, Wade, Kaitlin H, Richmond, Rebecca C, Langdon, Ryan J, Vincent, Emma E, Holmes, Michael V, Timpson, Nicholas J, Davey Smith, George
Published in PLoS medicine (28.08.2018)
Published in PLoS medicine (28.08.2018)
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Journal Article
Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study
Karjalainen, Minna K., Holmes, Michael V., Wang, Qin, Anufrieva, Olga, Kähönen, Mika, Lehtimäki, Terho, Havulinna, Aki S., Kristiansson, Kati, Salomaa, Veikko, Perola, Markus, Viikari, Jorma S., Raitakari, Olli T., Järvelin, Marjo-Riitta, Ala-Korpela, Mika, Kettunen, Johannes
Published in Atherosclerosis (01.04.2020)
Published in Atherosclerosis (01.04.2020)
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Journal Article
A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome
Wiberg, Akira, Ng, Michael, Schmid, Annina B, Smillie, Robert W, Baskozos, Georgios, Holmes, Michael V, Künnapuu, K, Mägi, R, Bennett, David L, Furniss, Dominic
Published in Nature communications (04.03.2019)
Published in Nature communications (04.03.2019)
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Journal Article
Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19
Bovijn, Jonas, Lindgren, Cecilia M, Holmes, Michael V
Published in The Lancet Rheumatology (01.11.2020)
Published in The Lancet Rheumatology (01.11.2020)
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Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
Bovijn, Jonas, Krebs, Kristi, Chen, Chia-Yen, Boxall, Ruth, Censin, Jenny C, Ferreira, Teresa, Pulit, Sara L, Glastonbury, Craig A, Laber, Samantha, Millwood, Iona Y, Lin, Kuang, Li, Liming, Chen, Zhengming, Milani, Lili, Smith, George Davey, Walters, Robin G, Mägi, Reedik, Neale, Benjamin M, Lindgren, Cecilia M, Holmes, Michael V
Published in Science translational medicine (24.06.2020)
Published in Science translational medicine (24.06.2020)
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Journal Article
Diabetes, plasma glucose and incidence of pancreatic cancer: A prospective study of 0.5 million Chinese adults and a meta‐analysis of 22 cohort studies
Pang, Yuanjie, Kartsonaki, Christiana, Guo, Yu, Bragg, Fiona, Yang, Ling, Bian, Zheng, Chen, Yiping, Iona, Andri, Millwood, Iona Y, Lv, Jun, Yu, Canqing, Chen, Junshi, Li, Liming, Holmes, Michael V, Chen, Zhengming
Published in International journal of cancer (15.04.2017)
Published in International journal of cancer (15.04.2017)
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Journal Article