Drugs for bad bugs: confronting the challenges of antibacterial discovery
Pompliano, David L, Payne, David J, Gwynn, Michael N, Holmes, David J
Published in Nature reviews. Drug discovery (01.01.2007)
Published in Nature reviews. Drug discovery (01.01.2007)
Get full text
Journal Article
Left Atrial Appendage Closure and Systemic Homeostasis: The LAA HOMEOSTASIS Study
Lakkireddy, Dhanunjaya, Turagam, Mohit, Afzal, Muhammad Rizwan, Rajasingh, Johnson, Atkins, Donita, Dawn, Buddhadeb, Di Biase, Luigi, Bartus, Krzysztof, Kar, Saibal, Natale, Andrea, Holmes, Jr, David J
Published in Journal of the American College of Cardiology (16.01.2018)
Published in Journal of the American College of Cardiology (16.01.2018)
Get full text
Journal Article
Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models
Rajpal, Deepak K, Klein, Jean-Louis, Mayhew, David, Boucheron, Joyce, Spivak, Aaron T, Kumar, Vinod, Ingraham, Karen, Paulik, Mark, Chen, Lihong, Van Horn, Stephanie, Thomas, Elizabeth, Sathe, Ganesh, Livi, George P, Holmes, David J, Brown, James R
Published in PloS one (28.12.2015)
Published in PloS one (28.12.2015)
Get full text
Journal Article
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections
O'Dwyer, Karen, Spivak, Aaron T, Ingraham, Karen, Min, Sharon, Holmes, David J, Jakielaszek, Charles, Rittenhouse, Stephen, Kwan, Alan L, Livi, George P, Sathe, Ganesh, Thomas, Elizabeth, Van Horn, Stephanie, Miller, Linda A, Twynholm, Monique, Tomayko, John, Dalessandro, Marybeth, Caltabiano, Madelyn, Scangarella-Oman, Nicole E, Brown, James R
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Get full text
Journal Article
Spatial and temporal dependencies of cross-orientation suppression in human vision
Meese, Tim S, Holmes, David J
Published in Proceedings of the Royal Society. B, Biological sciences (07.01.2007)
Published in Proceedings of the Royal Society. B, Biological sciences (07.01.2007)
Get full text
Journal Article
Stepwise Exposure of Staphylococcus aureus to Pleuromutilins Is Associated with Stepwise Acquisition of Mutations in rplC and Minimally Affects Susceptibility to Retapamulin
GENTRY, Daniel R, RITTENHOUSE, Stephen F, MCCLOSKEY, Lynn, HOLMES, David J
Published in Antimicrobial Agents and Chemotherapy (01.06.2007)
Published in Antimicrobial Agents and Chemotherapy (01.06.2007)
Get full text
Journal Article
Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus
GENTRY, Daniel R, MCCLOSKEY, Lynn, GWYNN, Michael N, RITTENHOUSE, Stephen F, SCANGARELLA, Nicole, SHAWAR, Ribhi, HOLMES, David J
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Get full text
Journal Article
Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery
Payne, David J, Warren, Patrick V, Holmes, David J, Ji, Yinduo, Lonsdale, John T
Published in Drug Discovery Today (01.05.2001)
Published in Drug Discovery Today (01.05.2001)
Get full text
Book Review
Journal Article
Characterization of a Novel Fucose-Regulated Promoter (PfcsK) Suitable for Gene Essentiality and Antibacterial Mode-of-Action Studies in Streptococcus pneumoniae
Chan, Pan F, O'Dwyer, Karen M, Palmer, Leslie M, Ambrad, Jennifer D, Ingraham, Karen A, So, Chi, Lonetto, Michael A, Biswas, Sanjoy, Rosenberg, Martin, Holmes, David J, Zalacain, Magdalena
Published in Journal of Bacteriology (01.03.2003)
Published in Journal of Bacteriology (01.03.2003)
Get full text
Journal Article
Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes
GENTRY, Daniel R, INGRAHAM, Karen A, STANHOPE, Michael J, RITTENHOUSE, Stephen, JARVEST, Richard L, O'HANLON, Peter J, BROWN, James R, HOLMES, David J
Published in Antimicrobial Agents and Chemotherapy (01.06.2003)
Published in Antimicrobial Agents and Chemotherapy (01.06.2003)
Get full text
Journal Article
Characterization of Streptococcus pneumoniae TrmD, a tRNA Methyltransferase Essential for Growth
O'DWYER, Karen, WATTS, Joseph M, BISWAS, Sanjoy, AMBRAD, Jennifer, BARBER, Michael, BRULE, Hervé, PETIT, Chantal, HOLMES, David J, ZALACAIN, Magdalena, HOLMES, Walter M
Published in Journal of Bacteriology (01.04.2004)
Published in Journal of Bacteriology (01.04.2004)
Get full text
Journal Article
CamDec: Advancing Axis P1435-LE video camera security using honeypot-based deception
Sikos, Leslie F., Valli, Craig, Grojek, Alexander E., Holmes, David J., Wakeling, Samuel G., Cabral, Warren Z., Karie, Nickson M.
Published in Journal of Computer Virology and Hacking Techniques (01.11.2023)
Published in Journal of Computer Virology and Hacking Techniques (01.11.2023)
Get full text
Journal Article
Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo
Čipčić Paljetak, Hana, Verbanac, Donatella, Padovan, Jasna, Dominis-Kramarić, Miroslava, Kelnerić, Željko, Perić, Mihaela, Banjanac, Mihailo, Ergović, Gabrijela, Simon, Nerrisa, Broskey, John, Holmes, David J, Eraković Haber, Vesna
Published in Antimicrobial agents and chemotherapy (01.09.2016)
Published in Antimicrobial agents and chemotherapy (01.09.2016)
Get full text
Journal Article
A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function
Zalacain, Magdalena, Biswas, Sanjoy, Ingraham, Karen A, Ambrad, Jennifer, Bryant, Alexander, Chalker, Alison F, Iordanescu, Serban, Fan, Jing, Fan, Frank, Lunsford, R Dwayne, O'Dwyer, Karen, Palmer, Leslie M, So, Chi, Sylvester, Daniel, Volker, Craig, Warren, Patrick, McDevitt, Damien, Brown, James R, Holmes, David J, Burnham, Martin K R
Published in Journal of molecular microbiology and biotechnology (01.01.2003)
Published in Journal of molecular microbiology and biotechnology (01.01.2003)
Get full text
Journal Article
Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
Min, Sharon, Ingraham, Karen, Huang, Jianzhong, McCloskey, Lynn, Rilling, Sarah, Windau, Anne, Pizzollo, Jason, Butler, Deborah, Aubart, Kelly, Miller, Linda A, Zalacain, Magdalena, Holmes, David J, O'Dwyer, Karen
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Get full text
Journal Article
Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase
Arat, Seda, Spivak, Aaron, Van Horn, Stephanie, Thomas, Elizabeth, Traini, Christopher, Sathe, Ganesh, Livi, George P, Ingraham, Karen, Jones, Lori, Aubart, Kelly, Holmes, David J, Naderer, Odin, Brown, James R
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Get full text
Journal Article
Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity
Kapić, Samra, Čipčić Paljetak, Hana, Palej Jakopović, Ivana, Fajdetić, Andrea, Ilijaš, Marina, Štimac, Vlado, Brajša, Karmen, Holmes, David J., Berge, John, Alihodžić, Sulejman
Published in Bioorganic & medicinal chemistry (01.12.2011)
Published in Bioorganic & medicinal chemistry (01.12.2011)
Get full text
Journal Article