Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (S)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)
Weinstein, David S, Gong, Hua, Doweyko, Arthur M, Cunningham, Mark, Habte, Sium, Wang, Jin Hong, Holloway, Deborah A, Burke, Christine, Gao, Ling, Guarino, Victor, Carman, Julie, Somerville, John E, Shuster, David, Salter-Cid, Luisa, Dodd, John H, Nadler, Steven G, Barrish, Joel C
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity
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Published in The Journal of immunology (1950) (01.02.2017)
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Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis
Nair, Satheesh, Kumar, Sreekantha Ratna, Paidi, Venkatram Reddy, Sistla, Ramesh, Kantheti, Durgarao, Polimera, Subba Rao, Thangavel, Soodamani, Mukherjee, Amrita Jha, Das, Mitalee, Bhide, Rajeev S, Pitts, William J, Murugesan, Natesan, Dudhgoankar, Shailesh, Nagar, Jignesh, Subramani, Siva, Mazumder, Debarati, Carman, Julie A, Holloway, Deborah A, Li, Xin, Fereshteh, Mark P, Ruepp, Stefan, Palanisamy, Kamalavenkatesh, Mariappan, T. Thanga, Maddi, Srinivas, Saxena, Ajay, Elzinga, Paul, Chimalakonda, Anjaneya, Ruan, Qian, Ghosh, Kaushik, Bose, Sucharita, Sack, John, Yan, Chunhong, Kiefer, Susan E, Xie, Dianlin, Newitt, John A, Saravanakumar, S. Pon, Rampulla, Richard A, Barrish, Joel C, Carter, Percy H, Hynes, John
Published in ACS medicinal chemistry letters (09.07.2020)
Published in ACS medicinal chemistry letters (09.07.2020)
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Improving the Pharmacokinetic and CYP Inhibition Profiles of Azaxanthene-Based Glucocorticoid Receptor ModulatorsIdentification of (S)‑5-(2-(9-Fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)‑5H‑chromeno[2,3‑b]pyridin-5-yl)-2-methylpropanamido)‑N‑(tetrahydro‑2H‑pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)
Yang, Michael G, Dhar, T. G. Murali, Xiao, Zili, Xiao, Hai-Yun, Duan, James J.-W, Jiang, Bin, Galella, Michael A, Cunningham, Mark, Wang, Jinhong, Habte, Sium, Shuster, David, McIntyre, Kim W, Carman, Julie, Holloway, Deborah A, Somerville, John E, Nadler, Steven G, Salter-Cid, Luisa, Barrish, Joel C, Weinstein, David S
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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B cells from African American lupus patients exhibit an activated phenotype
Menard, Laurence C, Habte, Sium, Gonsiorek, Waldemar, Lee, Deborah, Banas, Dana, Holloway, Deborah A, Manjarrez-Orduno, Nataly, Cunningham, Mark, Stetsko, Dawn, Casano, Francesca, Kansal, Selena, Davis, Patricia M, Carman, Julie, Zhang, Clarence K, Abidi, Ferva, Furie, Richard, Nadler, Steven G, Suchard, Suzanne J
Published in JCI insight (16.06.2016)
Published in JCI insight (16.06.2016)
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Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists
Yang, Bingwei V, Weinstein, David S, Doweyko, Lidia M, Gong, Hua, Vaccaro, Wayne, Huynh, Tram, Xiao, Hai-yun, Doweyko, Arthur M, Mckay, Lorraine, Holloway, Deborah A, Somerville, John E, Habte, Sium, Cunningham, Mark, McMahon, Michele, Townsend, Robert, Shuster, David, Dodd, John H, Nadler, Steven G, Barrish, Joel C
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
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Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators
Yang, Bingwei V., Vaccaro, Wayne, Doweyko, Arthur M., Doweyko, Lidia M., Huynh, Tram, Tortolani, David, Nadler, Steven G., McKay, Lorraine, Somerville, John, Holloway, Deborah A., Habte, Sium, Weinstein, David S., Barrish, Joel C.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Improving the Pharmacokinetic and CYP Inhibition Profiles of Azaxanthene-Based Glucocorticoid Receptor Modulators—Identification of ( S )-5-(2-(9-Fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5 H -chromeno[2,3- b ]pyridin-5-yl)-2-methylpropanamido)- N -(tetrahydro-2 H -pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)
Yang, Michael G., Dhar, T. G. Murali, Xiao, Zili, Xiao, Hai-Yun, Duan, James J.-W., Jiang, Bin, Galella, Michael A., Cunningham, Mark, Wang, Jinhong, Habte, Sium, Shuster, David, McIntyre, Kim W., Carman, Julie, Holloway, Deborah A., Somerville, John E., Nadler, Steven G., Salter-Cid, Luisa, Barrish, Joel C., Weinstein, David S.
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of ( S )-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5 H -chromeno[2,3- b ]pyridin-2-yl)-2-fluoro- N , N -dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)
Weinstein, David S., Gong, Hua, Doweyko, Arthur M., Cunningham, Mark, Habte, Sium, Wang, Jin Hong, Holloway, Deborah A., Burke, Christine, Gao, Ling, Guarino, Victor, Carman, Julie, Somerville, John E., Shuster, David, Salter-Cid, Luisa, Dodd, John H., Nadler, Steven G., Barrish, Joel C.
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Ventilatory changes in the golden hamster, Mesocricetus auratus, compared with the laboratory rat, Rattus norvegicus, during hypercapnia and/or hypoxia
Holloway, Deborah A, Heath, Alan G
Published in Comparative biochemistry and physiology. A, Comparative physiology (1984)
Published in Comparative biochemistry and physiology. A, Comparative physiology (1984)
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