Patient-centric trials for therapeutic development in precision oncology
Biankin, Andrew V, Piantadosi, Steven, Hollingsworth, Simon J
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Published in Nature (London) (15.10.2015)
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Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study
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Published in Clinical cancer research (01.10.2021)
Published in Clinical cancer research (01.10.2021)
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Tumor Genomic Profiling Guides Patients with Metastatic Gastric Cancer to Targeted Treatment: The VIKTORY Umbrella Trial
Lee, Jeeyun, Kim, Seung Tae, Kim, Kyung, Lee, Hyuk, Kozarewa, Iwanka, Mortimer, Peter G S, Odegaard, Justin I, Harrington, Elizabeth A, Lee, Juyoung, Lee, Taehyang, Oh, Sung Yong, Kang, Jung-Hun, Kim, Jung Hoon, Kim, Youjin, Ji, Jun Ho, Kim, Young Saing, Lee, Kyoung Eun, Kim, Jinchul, Sohn, Tae Sung, An, Ji Yeong, Choi, Min-Gew, Lee, Jun Ho, Bae, Jae Moon, Kim, Sung, Kim, Jae J, Min, Yang Won, Min, Byung-Hoon, Kim, Nayoung K D, Luke, Sally, Kim, Young Hwa, Hong, Jung Yong, Park, Se Hoon, Park, Joon Oh, Park, Young Suk, Lim, Ho Yeong, Talasaz, AmirAli, Hollingsworth, Simon J, Kim, Kyoung-Mee, Kang, Won Ki
Published in Cancer discovery (01.10.2019)
Published in Cancer discovery (01.10.2019)
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Defining actionable mutations for oncology therapeutic development
Carr, T Hedley, McEwen, Robert, Dougherty, Brian, Johnson, Justin H, Dry, Jonathan R, Lai, Zhongwu, Ghazoui, Zara, Laing, Naomi M, Hodgson, Darren R, Cruzalegui, Francisco, Hollingsworth, Simon J, Barrett, J Carl
Published in Nature reviews. Cancer (01.05.2016)
Published in Nature reviews. Cancer (01.05.2016)
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Biomarker‐driven phase 2 umbrella trial study for patients with recurrent small cell lung cancer failing platinum‐based chemotherapy
Park, Sehhoon, Shim, Joonho, Mortimer, Peter G. S., Smith, Simon A., Godin, Robert E., Hollingsworth, Simon J., Kim, Hee‐Jung, Jung, Hyun Ae, Sun, Jong‐Mu, Park, Woong‐Yang, Ahn, Jin Seok, Ahn, Myung‐Ju, Lee, Se‐Hoon, Park, Keunchil
Published in Cancer (01.09.2020)
Published in Cancer (01.09.2020)
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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
Fok, Jacqueline H L, Ramos-Montoya, Antonio, Vazquez-Chantada, Mercedes, Wijnhoven, Paul W G, Follia, Valeria, James, Neil, Farrington, Paul M, Karmokar, Ankur, Willis, Sophie E, Cairns, Jonathan, Nikkilä, Jenni, Beattie, David, Lamont, Gillian M, Finlay, M Raymond V, Wilson, Joanne, Smith, Aaron, O'Connor, Lenka Oplustil, Ling, Stephanie, Fawell, Stephen E, O'Connor, Mark J, Hollingsworth, Simon J, Dean, Emma, Goldberg, Frederick W, Davies, Barry R, Cadogan, Elaine B
Published in Nature communications (07.11.2019)
Published in Nature communications (07.11.2019)
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The impact of germline mutations on targeted therapy
Smith, Simon A, French, Tim, Hollingsworth, Simon J
Published in The Journal of pathology (01.01.2014)
Published in The Journal of pathology (01.01.2014)
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Phase I Pharmacokinetic and Pharmacodynamic Dose-Escalation Study of RG7160 (GA201), the First Glycoengineered Monoclonal Antibody Against the Epidermal Growth Factor Receptor, in Patients With Advanced Solid Tumors
PAZ-ARES, Luis G, GOMEZ-ROCA, Carlos, HOLLINGSWORTH, Simon, BASELGA, José, UMANA, Pablo, MANENTI, Luigi, TABERNERO, Josep, DELORD, Jean-Pierre, CERVANTES, Andres, MARKMAN, Ben, CORRAL, Jesus, SORIA, Jean-Charles, BERGE, Yann, RODA, Desamparados, RUSSELL-YARDE, Fiona
Published in Journal of clinical oncology (01.10.2011)
Published in Journal of clinical oncology (01.10.2011)
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Combination of Docetaxel Plus Savolitinib in Refractory Cancer Patients: A Report on Phase I Trial
Kim, Seung Tae, Lee, Sujin, Park, Minhwa, Park, Se Hoon, Park, Joon Oh, Lim, Ho Yeong, Park, Young Suk, Kang, Won Ki, Gangolli, Esha A., Shin, Hyeongchan, Kim, Kyoung-Mee, Hollingsworth, Simon J., Mortimer, Peter G.S., Lee, Jeeyun
Published in Translational oncology (01.04.2019)
Published in Translational oncology (01.04.2019)
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Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro
Jones, Neil A., Morton, Magda F., Prendergast, Clodagh E., Powell, Garth L., Shankley, Nigel P., Hollingsworth, Simon J.
Published in Regulatory peptides (11.09.2006)
Published in Regulatory peptides (11.09.2006)
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Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer
Tutt, Andrew N.J, Garber, Judy E, Kaufman, Bella, Viale, Giuseppe, Fumagalli, Debora, Rastogi, Priya, Gelber, Richard D, de Azambuja, Evandro, Fielding, Anitra, Balmaña, Judith, Domchek, Susan M, Gelmon, Karen A, Hollingsworth, Simon J, Korde, Larissa A, Linderholm, Barbro, Bandos, Hanna, Senkus, Elżbieta, Suga, Jennifer M, Shao, Zhimin, Pippas, Andrew W, Nowecki, Zbigniew, Huzarski, Tomasz, Ganz, Patricia A, Lucas, Peter C, Baker, Nigel, Loibl, Sibylle, McConnell, Robin, Piccart, Martine, Schmutzler, Rita, Steger, Guenther G, Costantino, Joseph P, Arahmani, Amal, Wolmark, Norman, McFadden, Eleanor, Karantza, Vassiliki, Lakhani, Sunil R, Yothers, Greg, Campbell, Christine, Geyer, Charles E
Published in The New England journal of medicine (24.06.2021)
Published in The New England journal of medicine (24.06.2021)
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Expression of angiogenic VEGF-A (soluble isoforms 121, 165) and lymphangiogenic VEGF-C in colorectal cancers with micro-satellite instability
Hollingsworth, Simon J., Drye, Elizabeth R., Tou, Samson I.H., Boulos, Paul B.
Published in Journal of surgical oncology (15.12.2005)
Published in Journal of surgical oncology (15.12.2005)
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VIOLETTE: A randomized phase II study to assess DNA damage response inhibitors in combination with olaparib (Ola) vs Ola monotherapy in patients (pts) with metastatic, triple-negative breast cancer (TNBC) stratified by alterations in homologous recombination repair (HRR)-related genes
Tutt, Andrew, Stephens, Christine, Frewer, Paul, Pierce, Andrew, Rhee, Joon, So, Karen, Ottesen, Lone, Dean, Emma, Hollingsworth, Simon J.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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VIOLETTE: A randomized phase II study to assess the DNA damage response inhibitors AZD6738 or AZD1775 in combination with olaparib (Ola) versus Ola monotherapy in patients (pts) with metastatic, triple-negative breast cancer (TNBC)
Tutt, Andrew, Stephens, Christine, Frewer, Paul, Pierce, Andrew, Rhee, Joon, Edgington, Sarah, Ottesen, Lone, Ah-See, Mei-Lin, Hollingsworth, Simon J., Dean, Emma
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Correction to: The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care
Cerone, Maria Antonietta, Mills, Tara C, Sharpe, Rowena, McBride, David, MacDonald, Moira, MacMahon, Suzanne, Mugalaasi, Hood, Rehal, Pauline, Rettino, Alessandro, Roberts, Helen, Ross, Mark, White, Donald Edward, Peden, John, Rawlinson, Janette, Ho, Steffan N, Hollingsworth, Simon, Popat, Sanjay, Middleton, Gary, Johnson, Peter, Swanton, Charles
Published in British journal of cancer (01.01.2023)
Published in British journal of cancer (01.01.2023)
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