Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C, Chen, Kaiwen W, Ross, Connie M, Teo, Jessica L, Gomez, Guillermo A, Holley, Caroline L, Bierschenk, Damien, Stacey, Katryn J, Yap, Alpha S, Bezbradica, Jelena S, Schroder, Kate
Published in The Journal of experimental medicine (05.03.2018)
Published in The Journal of experimental medicine (05.03.2018)
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Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion
Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L., Schroder, Kate
Published in Cell reports (Cambridge) (07.08.2018)
Published in Cell reports (Cambridge) (07.08.2018)
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Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses
Milner, Mark T., Lawrence, Grace MEP, Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S., Schroder, Kate
Published in STAR protocols (17.06.2022)
Published in STAR protocols (17.06.2022)
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Parkinson's disease: connecting mitochondria to inflammasomes
Lawrence, Grace M.E.P., Holley, Caroline L., Schroder, Kate
Published in Trends in immunology (01.11.2022)
Published in Trends in immunology (01.11.2022)
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Journal Article
Come on mtDNA, light my fire
Lawrence, Grace M.E.P., Holley, Caroline L., Schroder, Kate
Published in Immunity (Cambridge, Mass.) (09.08.2022)
Published in Immunity (Cambridge, Mass.) (09.08.2022)
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Journal Article
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Masters, Seth L, Lagou, Vasiliki, Jéru, Isabelle, Baker, Paul J, Van Eyck, Lien, Parry, David A, Lawless, Dylan, De Nardo, Dominic, Garcia-Perez, Josselyn E, Dagley, Laura F, Holley, Caroline L, Dooley, James, Moghaddas, Fiona, Pasciuto, Emanuela, Jeandel, Pierre-Yves, Sciot, Raf, Lyras, Dena, Webb, Andrew I, Nicholson, Sandra E, De Somer, Lien, van Nieuwenhove, Erika, Ruuth-Praz, Julia, Copin, Bruno, Cochet, Emmanuelle, Medlej-Hashim, Myrna, Megarbane, Andre, Schroder, Kate, Savic, Sinisa, Goris, An, Amselem, Serge, Wouters, Carine, Liston, Adrian
Published in Science translational medicine (30.03.2016)
Published in Science translational medicine (30.03.2016)
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NLRC3 Restrains Responses to a T
Holley, Caroline L., Coll, Rebecca C., Schroder, Kate
Published in Immunity (Cambridge, Mass.) (18.12.2018)
Published in Immunity (Cambridge, Mass.) (18.12.2018)
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Journal Article
The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis
Holley, Caroline L, Emming, Stefan, Monteleone, Mercedes M, Mellacheruvu, Manasa, Kenney, Kirsten M, Lawrence, Grace M E P, Coombs, Jared R, Burgener, Sabrina S, Schroder, Kate
Published in Cell chemical biology (16.05.2024)
Published in Cell chemical biology (16.05.2024)
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Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release
Labzin, Larisa I, Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J, Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E, Holley, Caroline L, Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L, Steinfort, Daniel P, Subbarao, Kanta, Nefzger, Christian M, Lagendijk, Anne K, Gordon, Emma J, Parton, Robert G, Short, Kirsty R, Londrigan, Sarah L, Schroder, Kate
Published in Science signaling (25.04.2023)
Published in Science signaling (25.04.2023)
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NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
Coombs, Jared R, Zamoshnikova, Alina, Holley, Caroline L, Maddugoda, Madhavi P, Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M, Mellacheruvu, Manasa, Coll, Rebecca C, Heinz, Leonhard X, Burgener, Sabrina S, Emming, Stefan, Chamaillard, Mathias, Boucher, Dave, Schroder, Kate
Published in Science signaling (23.01.2024)
Published in Science signaling (23.01.2024)
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Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Holley, Caroline L, Monteleone, Mercedes, Fisch, Daniel, Libert, Alexandre E S, Ju, Robert J, Choi, Joon H, Condon, Nicholas D, Emming, Stefan, Crawford, Joanna, Lawrence, Grace M E P, Coombs, Jared R, Lefevre, James G, Bajracharya, Rinie, Lahoud, Mireille H, Yap, Alpha S, Hamilton, Nicholas, Stehbens, Samantha J, Kagan, Jonathan C, Ariotti, Nicholas, Burgener, Sabrina S, Schroder, Kate
Published in Nature immunology (04.12.2024)
Published in Nature immunology (04.12.2024)
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Journal Article
Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors
Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A., Robertson, Avril A. B.
Published in ChemMedChem (07.09.2017)
Published in ChemMedChem (07.09.2017)
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