R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer
HOLLAND, Sacha J, PAN, Alison, JING ZHANG, PINGYU DING, APATIRA, Ayodele, CHUA, Joanne, BRANDT, Ralf, PINE, Polly, GOFF, Dane, SINGH, Rajinder, PAYAN, Donald G, HITOSHI, Yasumichi, FRANCI, Christian, YUANMING HU, CHANG, Betty, WEIQUN LI, DUAN, Matt, TORNEROS, Allan, JIAXIN YU, HECKRODT, Thilo J
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Journal Article
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
Hector, Alvarez, Montgomery, Elizabeth A., Karikari, Collins, Canto, Marcia I., Dunbar, Kerry B., Wang, Jean S., Feldmann, Georg, Hong, Seung-Mo, Haffner, Michael C., Meeker, Alan K., Holland, Sacha J., Yu, Jiaxin, Heckrodt, Thilo J., Zhang, Jing, Ding, Pingyu, Goff, Dane, Singh, Rajinder, Roa, Juan Carlos, Marimuthu, Arivusudar, Riggins, Gregory J., Eshleman, James R., Nelkin, Barry D., Pandey, Akhilesh, Maitra, Anirban
Published in Cancer biology & therapy (15.11.2010)
Published in Cancer biology & therapy (15.11.2010)
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Journal Article
Multiple roles for the receptor tyrosine kinase axl in tumor formation
HOLLAND, Sacha J, POWELL, Mark J, WONG, Stephen, LASAGA, Joe, SHEN, Mary R, SIMON YU, WEIDUAN XU, HITOSHI, Yasumichi, BOGENBERGER, Jakob, NÖR, Jacques E, PAYAN, Donald G, LORENS, James B, FRANCI, Christian, CHAN, Emily W, FRIERA, Annabelle M, ATCHISON, Robert E, MCLAUGHLIN, John, SWIFT, Susan E, PALI, Erlina S, YAM, George
Published in Cancer research (Chicago, Ill.) (15.10.2005)
Published in Cancer research (Chicago, Ill.) (15.10.2005)
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Journal Article
Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis
Gale, Nicholas W, Holland, Sacha J, Valenzuela, David M, Flenniken, Ann, Pan, Li, Ryan, Terrence E, Henkemeyer, Mark, Strebhardt, Klaus, Hirai, Hisamaru, Wilkinson, David G, Pawson, Tony, Davis, Samuel, Yancopoulos, George D
Published in Neuron (Cambridge, Mass.) (01.07.1996)
Published in Neuron (Cambridge, Mass.) (01.07.1996)
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Journal Article
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
Holland, Sacha J., Gale, Nicholas W., Gish, Gerald D., Roth, Richard A., Songyang, Zhou, Cantley, Lewis C., Henkemeyer, Mark, Yancopoulos, George D., Pawson, Tony
Published in The EMBO journal (01.07.1997)
Published in The EMBO journal (01.07.1997)
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Journal Article
Downregulation of the Ras–Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction
Elowe, Sabine, Holland, Sacha J., Kulkarni, Sarang, Pawson, Tony
Published in Molecular and Cellular Biology (01.11.2001)
Published in Molecular and Cellular Biology (01.11.2001)
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Journal Article
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
McLaughlin, John, Markovtsov, Vadim, Li, Hui, Wong, Steve, Gelman, Marina, Zhu, Yanhong, Franci, Christian, Lang, D. Wayne, Pali, Erlina, Lasaga, Joe, Low, Caroline, Zhao, Feifei, Chang, Betty, Gururaja, Tarikere L, Xu, Weiduan, Baluom, Muhammad, Sweeny, David, Carroll, David, Sran, Arvinder, Thota, Sambaiah, Parmer, Manjeet, Romane, Angela, Clemens, George, Grossbard, Elliott, Qu, Kunbin, Jenkins, Yonchu, Kinoshita, Taisei, Taylor, Vanessa, Holland, Sacha J, Argade, Ankush, Singh, Rajinder, Pine, Polly, Payan, Donald G, Hitoshi, Yasumichi
Published in Journal of cancer research and clinical oncology (2010)
Published in Journal of cancer research and clinical oncology (2010)
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Journal Article
Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors
Binns, Kathleen L., Taylor, Paul P., Sicheri, Frank, Pawson, Tony, Holland, Sacha J.
Published in Molecular and Cellular Biology (01.07.2000)
Published in Molecular and Cellular Biology (01.07.2000)
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Journal Article
Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling
Holland, S J, Liao, X C, Mendenhall, M K, Zhou, X, Pardo, J, Chu, P, Spencer, C, Fu, A, Sheng, N, Yu, P, Pali, E, Nagin, A, Shen, M, Yu, S, Chan, E, Wu, X, Li, C, Woisetschlager, M, Aversa, G, Kolbinger, F, Bennett, M K, Molineaux, S, Luo, Y, Payan, D G, Mancebo, H S, Wu, J
Published in The Journal of experimental medicine (05.11.2001)
Published in The Journal of experimental medicine (05.11.2001)
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Journal Article
Abstract 4869: Small molecule inhibitors of the anti-inflammatory TAM receptor MerTK
Holland, Sacha J., Owyang, Alex M., Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Arthur, Tai, Ernest, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Duncton, Matthew, Singh, Rajinder, Masuda, Esteban, Payan, Donald G.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 2546: AXL targeted therapy blocks tumor progression and prevents tumor metastasis in pancreatic cancer
Rajeshkumar, N.V., Karikari, Collins, DeOliveira, Elizabeth, de Wilde, Roeland F., Holland, Sacha J., Payan, Donald G., Maitra, Anirban
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
Holland, Sacha J., Gale, Nicholas W., Gish, Gerald D., Roth, Richard A., Songyang, Zhou, Cantley, Lewis C., Henkemeyer, Mark, Yancopoulos, George D., Pawson, Tony
Published in The EMBO journal (01.07.1997)
Published in The EMBO journal (01.07.1997)
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Journal Article
Multiple Ephrins Control Cell Organization in C. elegans Using Kinase-Dependent and -Independent Functions of the VAB-1 Eph Receptor
Wang, Xiangmin, Roy, Peter J., Holland, Sacha J., Zhang, Lijia W., Culotti, Joseph G., Pawson, Tony
Published in Molecular cell (01.12.1999)
Published in Molecular cell (01.12.1999)
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Journal Article
2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES
Holland, Sacha J, Clough, Jeffrey, Li, Hui, Bhamidipsti, Somasekhar, Singh, Rajinder, Rossi, Alexander B, Sylvain, Catherine, Argade, Ankush, Payan, Donald G, Keim, Holger, Molineaux, Susan
Year of Publication 02.09.2021
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Year of Publication 02.09.2021
Patent
2,4-pyrimidinediamine compounds and their uses
Holland, Sacha J, Clough, Jeffrey, Li, Hui, Bhamidipati, Somasekhar, Singh, Rajinder, Rossi, Alexander B, Sylvain, Catherine, Argade, Ankush, Payan, Donald G, Keim, Holger, Molineaux, Susan
Year of Publication 18.05.2021
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Year of Publication 18.05.2021
Patent
2,4-pyrimidinediamine compounds and their uses
Holland, Sacha J, Clough, Jeffrey, Li, Hui, Bhamidipati, Somasekhar, Singh, Rajinder, Rossi, Alexander B, Sylvain, Catherine, Argade, Ankush, Payan, Donald G, Keim, Holger, Molineaux, Susan
Year of Publication 10.11.2020
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Year of Publication 10.11.2020
Patent
2,4-pyrimidinediamine compounds and their uses
Holland, Sacha J, Clough, Jeffrey, Li, Hui, Bhamidipati, Somasekhar, Singh, Rajinder, Rossi, Alexander B, Sylvain, Catherine, Argade, Ankush, Payan, Donald, Keim, Holger, Molineaux, Susan
Year of Publication 14.07.2020
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Year of Publication 14.07.2020
Patent
2,4-pyrimidinediamine compounds and their uses
Holland, Sacha J, Clough, Jeffrey, Li, Hui, Bhamidipati, Somasekhar, Singh, Rajinder, Rossi, Alexander B, Sylvain, Catherine, Argade, Ankush, Payan, Donald, Keim, Holger, Molineaux, Susan
Year of Publication 16.06.2020
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Year of Publication 16.06.2020
Patent