Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives
Basudhar, Debashree, Bharadwaj, Gaurav, Cheng, Robert Y, Jain, Sarthak, Shi, Sa, Heinecke, Julie L, Holland, Ryan J, Ridnour, Lisa A, Caceres, Viviane M, Spadari-Bratfisch, Regina C, Paolocci, Nazareno, Velázquez-Martínez, Carlos A, Wink, David A, Miranda, Katrina M
Published in Journal of medicinal chemistry (24.10.2013)
Published in Journal of medicinal chemistry (24.10.2013)
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Journal Article
Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs
Nandurdikar, Rahul S., Maciag, Anna E., Holland, Ryan J., Cao, Zhao, Shami, Paul J., Anderson, Lucy M., Keefer, Larry K., Saavedra, Joseph E.
Published in Bioorganic & medicinal chemistry (01.05.2012)
Published in Bioorganic & medicinal chemistry (01.05.2012)
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Journal Article
The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet
Maslak, Edyta, Zabielski, Piotr, Kochan, Kamila, Kus, Kamil, Jasztal, Agnieszka, Sitek, Barbara, Proniewski, Bartosz, Wojcik, Tomasz, Gula, Katarzyna, Kij, Agnieszka, Walczak, Maria, Baranska, Małgorzata, Chabowski, Adrian, Holland, Ryan J., Saavedra, Joseph E., Keefer, Larry K., Chlopicki, Stefan
Published in Biochemical pharmacology (01.02.2015)
Published in Biochemical pharmacology (01.02.2015)
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Journal Article
Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics
Kus, Kamil, Walczak, Maria, Maslak, Edyta, Zakrzewska, Agnieszka, Gonciarz-Dytman, Anna, Zabielski, Piotr, Sitek, Barbara, Wandzel, Krystyna, Kij, Agnieszka, Chabowski, Adrian, Holland, Ryan J, Saavedra, Joseph E, Keefer, Larry K, Chlopicki, Stefan
Published in Drug metabolism and disposition (01.07.2015)
Published in Drug metabolism and disposition (01.07.2015)
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Journal Article
Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S‑Transferase P1-Overexpressing Cancer Cells
Maciag, Anna E, Holland, Ryan J, Kim, Youseung, Kumari, Vandana, Luthers, Christina E, Sehareen, Waheed S, Biswas, Debanjan, Morris, Nicole L, Ji, Xinhua, Anderson, Lucy M, Saavedra, Joseph E, Keefer, Larry K
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates
Holland, Ryan J, Klose, John R, Deschamps, Jeffrey R, Cao, Zhao, Keefer, Larry K, Saavedra, Joseph E
Published in Journal of organic chemistry (03.10.2014)
Published in Journal of organic chemistry (03.10.2014)
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Journal Article
The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species
Maciag, Anna E, Chakrapani, Harinath, Saavedra, Joseph E, Morris, Nicole L, Holland, Ryan J, Kosak, Ken M, Shami, Paul J, Anderson, Lucy M, Keefer, Larry K
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Journal Article
PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells
Kim, Youseung, Maciag, Anna E., Cao, Zhao, Deschamps, Jeffrey R., Saavedra, Joseph E., Keefer, Larry K., Holland, Ryan J.
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
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Journal Article
Decoding Nitric Oxide Release Rates of Amine-Based Diazeniumdiolates
Wang, Yan-Ni, Collins, Jack, Holland, Ryan J, Keefer, Larry K, Ivanic, Joseph
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (01.08.2013)
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (01.08.2013)
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Journal Article
“Click” Reaction in Conjunction with Diazeniumdiolate Chemistry: Developing High-Load Nitric Oxide Donors
Oladeinde, Oyebola A, Hong, Sam Y, Holland, Ryan J, Maciag, Anna E, Keefer, Larry K, Saavedra, Joseph E, Nandurdikar, Rahul S
Published in Organic letters (01.10.2010)
Published in Organic letters (01.10.2010)
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Journal Article
Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells
Kaczmarek, Monika Z, Holland, Ryan J, Lavanier, Stephen A, Troxler, Jami A, Fesenkova, Valentyna I, Hanson, Charlotte A, Cmarik, Joan L, Saavedra, Joseph E, Keefer, Larry K, Ruscetti, Sandra K
Published in Leukemia research (01.03.2014)
Published in Leukemia research (01.03.2014)
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Journal Article
Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate
Kumari, Vandana, Dyba, Marzena A, Holland, Ryan J, Liang, Yu-He, Singh, Shivendra V, Ji, Xinhua
Published in PloS one (29.09.2016)
Published in PloS one (29.09.2016)
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Journal Article
O-2-Functionalized Methylamine Diazeniumdiolates: Evidence for E reversible arrow Z Equilibration in an Acyclic System
Biswas, Debanjan, Holland, Ryan J., Deschamps, Jeffrey R., Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E.
Published in Journal of organic chemistry (07.12.2012)
Published in Journal of organic chemistry (07.12.2012)
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Journal Article
Cancer Cell-Directed Drug Delivery and Chemopotentiating Effects by GSTP1-Activated Nitric Oxide (NO)-Releasing Prodrug
Kumari, Vandana, Holland, Ryan J., Luthers, Christina E., Dyba, Marzena A., Tarasov, Sergey G., Saavedra, Joseph E., Keefer, Larry K., Ji, Xinhua
Published in Biophysical journal (16.02.2016)
Published in Biophysical journal (16.02.2016)
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Journal Article