In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response
Sahu, Aditi, Kose, Kivanc, Kraehenbuehl, Lukas, Byers, Candice, Holland, Aliya, Tembo, Teguru, Santella, Anthony, Alfonso, Anabel, Li, Madison, Cordova, Miguel, Gill, Melissa, Fox, Christi, Gonzalez, Salvador, Kumar, Piyush, Wang, Amber Weiching, Kurtansky, Nicholas, Chandrani, Pratik, Yin, Shen, Mehta, Paras, Navarrete-Dechent, Cristian, Peterson, Gary, King, Kimeil, Dusza, Stephen, Yang, Ning, Liu, Shuaitong, Phillips, William, Guitera, Pascale, Rossi, Anthony, Halpern, Allan, Deng, Liang, Pulitzer, Melissa, Marghoob, Ashfaq, Chen, Chih-Shan Jason, Merghoub, Taha, Rajadhyaksha, Milind
Published in Nature communications (09.09.2022)
Published in Nature communications (09.09.2022)
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Journal Article
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade
Ghosh, Arnab, Michels, Judith, Mezzadra, Riccardo, Venkatesh, Divya, Dong, Lauren, Gomez, Ricardo, Samaan, Fadi, Ho, Yu-Jui, Campesato, Luis Felipe, Mangarin, Levi, Fak, John, Suek, Nathan, Holland, Aliya, Liu, Cailian, Abu-Akeel, Mohsen, Bykov, Yonina, Zhong, Hong, Fitzgerald, Kelly, Budhu, Sadna, Chow, Andrew, Zappasodi, Roberta, Panageas, Katherine S, de Henau, Olivier, Ruscetti, Marcus, Lowe, Scott W, Merghoub, Taha, Wolchok, Jedd D
Published in The Journal of clinical investigation (15.09.2022)
Published in The Journal of clinical investigation (15.09.2022)
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Journal Article
Comparative study of immune response to local tumor destruction modalities in a murine breast cancer model
Budhu, Sadna, Kim, Kwanghee, Yip, Wesley, La Rosa, Stephen, Jebiwott, Sylvia, Cai, Liqun, Holland, Aliya, Thomas, Jasmine, Preise, Dina, Somma, Alex, Gordon, Benjamin, Scherz, Avigdor, Wolchok, Jedd D, Erinjeri, Joseph, Merghoub, Taha, Coleman, Jonathan A
Published in Frontiers in oncology (18.06.2024)
Published in Frontiers in oncology (18.06.2024)
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Journal Article
Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma
Kraehenbuehl, Lukas, Holland, Aliya, Armstrong, Emma, O'Shea, Sirinya, Mangarin, Levi, Chekalil, Sara, Johnston, Amanda, Bomalaski, John S, Erinjeri, Joseph P, Barker, Christopher A, Francis, Jasmine H, Wolchok, Jedd D, Merghoub, Taha, Shoushtari, Alexander N
Published in Cancers (26.05.2022)
Published in Cancers (26.05.2022)
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Journal Article
Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
Gupta, Aditi, Budhu, Sadna, Fitzgerald, Kelly, Giese, Rachel, Michel, Adam O, Holland, Aliya, Campesato, Luis Felipe, van Snick, Jacques, Uyttenhove, Catherine, Ritter, Gerd, Wolchok, Jedd D, Merghoub, Taha
Published in Communications biology (17.11.2021)
Published in Communications biology (17.11.2021)
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Journal Article
878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
567 Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of stroma poor cancers
Budhu, Sadna, Gupta, Aditi, Fitzgerald, Kelly, Giese, Rachel, Michel, Adam, Holland, Aliya, Campesato, Luis Felipe, Snick, Jacques Van, Uyttenhove, Catherine, Ritter, Gerd, Wolchok, Jedd, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M., Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B., Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A., Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J., Arora, Arshi, Panageas, Katherine S., Rizzuto, Gabrielle A., Duhen, Rebekka, Weinberg, Andrew D., Spencer, Christine N., Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D., Merghoub, Taha
Published in Cell (30.03.2023)
Published in Cell (30.03.2023)
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Phase IB Study of GITR Agonist Antibody TRX518 Singly and in Combination with Gemcitabine, Pembrolizumab or Nivolumab in Patients with Advanced Solid Tumors
Davar, Diwakar, Zappasodi, Roberta, Wang, Hong, Naik, Girish S, Sato, Takami, Bauer, Todd, Bajor, David, Rixe, Olivier, Newman, Walter, Qi, Jingjing, Holland, Aliya, Wong, Phillip, Sifferlen, Lianna, Piper, Diane, Sirard, Cynthia A, Merghoub, Taha, Wolchok, Jedd D, Luke, Jason J
Published in Clinical cancer research (15.09.2022)
Published in Clinical cancer research (15.09.2022)
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Journal Article
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer
Segal, Neil H, Cercek, Andrea, Ku, Geoffrey, Wu, Abraham J, Rimner, Andreas, Khalil, Danny N, Reidy-Lagunes, Diane, Cuaron, John, Yang, T Jonathan, Weiser, Martin R, Romesser, Paul B, Stadler, Zsofia K, Varghese, Anna M, Ganesh, Karuna, Yaeger, Rona, Connell, Louise C, Faleck, David, Abou-Alfa, Ghassan K, Mcauliffe, Kathleen C, Vaiskauskas, Pamela, Solter, Mark L, Ogle, Martinique, Adamow, Matthew J, Holland, Aliya, Vedantam, Pallavi, Wong, Phillip, Merghoub, Taha, Vakiani, Efsevia, Hollmann, Travis J, Juluru, Krishna, Chou, Joanne F, Capanu, Marinela, Erinjeri, Joseph, Solomon, Stephen, Yamada, Yoshiya, Kemeny, Nancy, Crane, Christopher H, Saltz, Leonard B
Published in Clinical cancer research (15.04.2021)
Published in Clinical cancer research (15.04.2021)
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Journal Article
The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer
Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.
Published in Immunity (Cambridge, Mass.) (10.01.2023)
Published in Immunity (Cambridge, Mass.) (10.01.2023)
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Study to evaluate intraperitoneal (IP) ONCOS-102 with systemic durvalumab in patients with peritoneal disease who have epithelial ovarian (OC) or metastatic colorectal cancer (CRC): Phase 2 results
Zamarin, Dmitriy, Odunsi, Kunle, Zsiros, Emese, Slomovitz, Brian M., Pimentel, Agustin, Duska, Linda R., Reilley, Matthew, Nemunaitis, John J., Hamouda, Danae M., Patel, Hitendra, Segal, Neil Howard, Pesci, Giulio, Holland, Aliya, Shohara, Lisa, Schwarzenberger, Paul Otto, Ricciardi, Toni, Macri, Mary J., Ryan, Aileen, Jaderberg, Magnus Erik, Venhaus, Ralph Rudolph
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Dysfunctional CD8+ T cells in the tumor microenvironment are associated with response to nivolumab in mismatch repair deficient (dMMR) or hypermutated ovarian (OVCA) or endometrial cancer (EC)
Friedman, Claire Frances, Zhou, Qin, Iasonos, Alexia, Holland, Aliya, Ramirez, Lizbeth, Grisham, Rachel N., Guo, Robin, Lichtman, Stuart M., Kyi, Chrisann, Makker, Vicky, Mueller, Jennifer Jean, O'Cearbhaill, Roisin Eilish, Schram, Alison M., Tew, William P., Konner, Jason A., Troso-Sandoval, Tiffany A., Wibmer, Andreas Georg, Aghajanian, Carol, Hensley, Martee Leigh, Zamarin, Dmitriy
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses
Friedman, Claire F, Manning-Geist, Beryl L, Zhou, Qin, Soumerai, Tara, Holland, Aliya, Da Cruz Paula, Arnaud, Green, Hunter, Ozsoy, Melih Arda, Iasonos, Alexia, Hollmann, Travis, Leitao, Jr, Mario M, Mueller, Jennifer J, Makker, Vicky, Tew, William P, O'Cearbhaill, Roisin E, Liu, Ying L, Rubinstein, Maria M, Troso-Sandoval, Tiffany, Lichtman, Stuart M, Schram, Alison, Kyi, Chrisann, Grisham, Rachel N, Causa Andrieu, Pamela, Wherry, E John, Aghajanian, Carol, Weigelt, Britta, Hensley, Martee L, Zamarin, Dmitriy
Published in Nature medicine (01.05.2024)
Published in Nature medicine (01.05.2024)
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Journal Article
Phase I/II study to evaluate systemic durvalumab + intraperitoneal (IP) ONCOS-102 in patients with peritoneal disease who have epithelial ovarian (OC) or metastatic colorectal cancer (CRC): Interim phase I clinical and translational results
Zamarin, Dmitriy, Odunsi, Kunle, Slomovitz, Brian M., Duska, Linda R., Nemunaitis, John J., Reilley, Matthew, Bykov, Yonina, Holland, Aliya, Hubbard-Lucey, Vanessa M., Shohara, Lisa, Schwarzenberger, Paul, Ricciardi, Toni, Macri, Mary J., Ryan, Aileen, Jaderberg, Magnus Erik, Venhaus, Ralph Rudolph
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Safety, immunogenicity, and clinical efficacy of durvalumab in combination with folate receptor alpha vaccine TPIV200 in patients with advanced ovarian cancer: a phase II trial
Zamarin, Dmitriy, Walderich, Sven, Holland, Aliya, Zhou, Qin, Iasonos, Alexia E, Torrisi, Jean M, Merghoub, Taha, Chesebrough, Lewis F, Mcdonnell, Autumn S, Gallagher, Jacqueline M, Li, Yanyun, Hollmann, Travis J, Grisham, Rachel N, Erskine, Courtney L, Block, Mathew S, Knutson, Keith L, O'Cearbhaill, Roisin E, Aghajanian, Carol, Konner, Jason A
Published in Journal for immunotherapy of cancer (01.06.2020)
Published in Journal for immunotherapy of cancer (01.06.2020)
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Journal Article
997 T cell immunotherapies trigger neutrophils to eliminates heterogenous tumors
Budhu, Sadna, Redmond, David, Ricca, Jacob, Gasmi, Billel, Gigoux, Mathieu, Liu, Cailian, Li, Yanyun, Cortez, Czrina, Schroder, David, Arora, Arshi, Hollman, Travis, Kraehenbuehl, Lukas, Choi, Hyejin, Schad, Sara, Schulze, Isabell, Duhen, Rebekka, Weinberg, Andrew, Chow, Andrew, Egeblad, Mikala, Panageas, Katherine, Rizzuto, Gabrielle, de Henau, Olivier, Holland, Aliya, Albrengues, Jean, Hamadane, Linda, Ng, David, Xue-Yan, He, Wolchok, Jedd, Taha Merghoub, Hirschhorn, Daniel
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 250: Activating canonical p53 functions in tumor-associated macrophages improves immune checkpoint blockade efficacy
Ghosh, Arnab, Michel, Judith, Venkatesh, Divya, Mezzadra, Riccardo, Dong, Lauren, Samaan, Fadi, Gomez, Ricardo, Suek, Nathan, Holland, Aliya, Ho, Yu-Jui, Abu-Akeel, Mohsen, Campesato, Luis Felipe, Mangarin, Levi Mark Bala, Liu, Cailian, Zhong, Hong, Budhu, Sadna, Chow, Andrew, Zappasodi, Roberta, Ruscetti, Marcus, Lowe, Scott W., Merghoub, Taha, Wolchok, Jedd D.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Clinical and molecular correlates of CD39+ CD8 T cells in patients with lung cancer
Chow, Andrew, Uddin, Fathema Z, Levi Mangarin, Rizvi, Hira, Dobrin, Anton, Tischfield, Sam E, Quintanal-Villalonga, Alvaro, Chan, Joseph M, Shah, Nisargbhai S, Allaj, Viola, Parvathy Manoj, Mattar, Marissa, Meneses, Maximiliano, Liu, Michael, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Chavan, Shweta, Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn-Cymerman, Daniel, Richards, Allison, Mark Ta Donoghue, Heller, Glenn, Klebanoff, Christopher A, Hellmann, Matthew D, De Stanchina, Elisa, Sen, Triparna, Wolchok, Jedd D, Taha Merghoub, Rudin, Charles M
Published in bioRxiv (12.05.2022)
Published in bioRxiv (12.05.2022)
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