Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
Grabinski, Nicole, Ewald, Florian, Hofmann, Bianca T, Staufer, Katharina, Schumacher, Udo, Nashan, Björn, Jücker, Manfred
Published in Molecular cancer (20.11.2012)
Published in Molecular cancer (20.11.2012)
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Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α
Sun, Minghao, Hillmann, Petra, Hofmann, Bianca T, Hart, Jonathan R, Vogt, Peter K
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
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Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
Ewald, Florian, Grabinski, Nicole, Grottke, Astrid, Windhorst, Sabine, Nörz, Dominik, Carstensen, Lisa, Staufer, Katharina, Hofmann, Bianca T., Diehl, Frank, David, Kerstin, Schumacher, Udo, Nashan, Björn, Jücker, Manfred
Published in International journal of cancer (01.11.2013)
Published in International journal of cancer (01.11.2013)
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Journal Article
Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Hofmann, Bianca T., Nashan, Björn, Jücker, Manfred
Published in Investigational new drugs (01.12.2014)
Published in Investigational new drugs (01.12.2014)
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Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer
Lerbs, Tristan, Bisht, Savita, Schölch, Sebastian, Pecqueux, Mathieu, Kristiansen, Glen, Schneider, Martin, Hofmann, Bianca T, Welsch, Thilo, Reissfelder, Christoph, Rahbari, Nuh N, Fritzmann, Johannes, Brossart, Peter, Weitz, Jürgen, Feldmann, Georg, Kahlert, Christoph
Published in BMC cancer (07.04.2017)
Published in BMC cancer (07.04.2017)
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Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma
Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T, Nashan, Björn, Jücker, Manfred
Published in Journal of Cancer (01.01.2015)
Published in Journal of Cancer (01.01.2015)
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Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer
Hofmann, Bianca T, Picksak, Aeint-Steffen, Kwiatkowski, Marcel, Grupp, Katharina, Jücker, Manfred, Bachmann, Kai, Mercanoglu, Baris, Izbicki, Jakob R, Kahlert, Christoph, Bockhorn, Maximilian, Güngör, Cenap, Ewald, Florian, Wolters-Eisfeld, Gerrit
Published in Glycobiology (Oxford) (24.04.2024)
Published in Glycobiology (Oxford) (24.04.2024)
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Journal Article
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
Hofmann, Bianca T, Schlüter, Laura, Lange, Philip, Mercanoglu, Baris, Ewald, Florian, Fölster, Aljonna, Picksak, Aeint-Steffen, Harder, Sönke, El Gammal, Alexander T, Grupp, Katharina, Güngör, Cenap, Drenckhan, Astrid, Schlüter, Hartmut, Wagener, Christoph, Izbicki, Jakob R, Jücker, Manfred, Bockhorn, Maximilian, Wolters-Eisfeld, Gerrit
Published in Molecular cancer (29.05.2015)
Published in Molecular cancer (29.05.2015)
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Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer
Konczalla, Leonie, Perez, Daniel R., Wenzel, Nadine, Wolters‐Eisfeld, Gerrit, Klemp, Clarissa, Lüddeke, Johanna, Wolski, Annika, Landschulze, Dirk, Meier, Chris, Buchholz, Anika, Yao, Dichao, Hofmann, Bianca T., Graß, Julia K., Spriestersbach, Sarah L., Grupp, Katharina, Schumacher, Udo, Betzel, Christian, Kapis, Svetlana, Nuguid, Theresa, Steinberg, Pablo, Püschel, Klaus, Sauter, Guido, Bockhorn, Maximillian, Uzunoglu, Faik G., Izbicki, Jakob R., Güngör, Cenap, El Gammal, Alexander T.
Published in International journal of cancer (15.03.2020)
Published in International journal of cancer (15.03.2020)
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Journal Article
ABO blood group IgM isoagglutinins interact with tumor-associated O-glycan structures in pancreatic cancer
Hofmann, Bianca T, Stehr, Anne, Dohrmann, Thorsten, Güngör, Cenap, Herich, Lena, Hiller, Jens, Harder, Sönke, Ewald, Florian, Gebauer, Florian, Tachezy, Michael, Precht, Clarissa, Izbicki, Jakob R, Bockhorn, Maximilian, Wagener, Christoph, Wolters-Eisfeld, Gerrit
Published in Clinical cancer research (01.12.2014)
Published in Clinical cancer research (01.12.2014)
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Journal Article
Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion
Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T., Nashan, Bjorn, Jücker, Manfred, Ewald, Florian
Published in Cellular signalling (01.11.2015)
Published in Cellular signalling (01.11.2015)
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Journal Article
Loss of complex O-glycosylation impairs exocrine pancreatic function and induces MODY8-like diabetes in mice
Wolters-Eisfeld, Gerrit, Mercanoglu, Baris, Hofmann, Bianca T., Wolpers, Thomas, Schnabel, Claudia, Harder, Sönke, Steffen, Pascal, Bachmann, Kai, Steglich, Babett, Schrader, Jörg, Gagliani, Nicola, Schlüter, Hartmut, Güngör, Cenap, Izbicki, Jakob R., Wagener, Christoph, Bockhorn, Maximilian
Published in Experimental & molecular medicine (10.10.2018)
Published in Experimental & molecular medicine (10.10.2018)
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Journal Article
Aberrant O-GalNAc glycosylation to enhance AKT/mTOR signaling in pancreatic cancer
Hofmann, Bianca T., Picksak, Aeint-Steffen, Kwiatkowski, Marcel, Izbicki, Jakob R., Bockhorn, Maximillian, Guengoer, Cenap, Ewald, Florian, Wolters-Eisfeld, Gerrit
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
Inhibition of MALT1 paracaspase by mepazine to decrease proliferation and enhance apoptosis in pancreatic cancer
El Gammal, Alexander T., Konczalla, Leonie, Scholz, Nadine, Guengoer, Cenap, Wolters-Eisfeld, Gerrit, Hofmann, Bianca T., Bockhorn, Maximilian, Vashist, Yogesh Kumar, Stein, Alexander, Izbicki, Jakob R., Perez, Daniel R.
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Inhibition of MALT1 protease with biperiden or mepazine: A new therapeutic treatment approach in pancreatic cancer
El Gammal, Alexander T., Konczalla, Leonie, Scholz, Nadine, Klemp, Clarissa, Lueddeke, Johanna, Wolski, Annika, Dichao, Yao, Wolters-Eisfeld, Gerrit, Julia, Baukloh, Hofmann, Bianca T., Spriesterbach, Sarah L, Grupp, Katharina, Betzel, Christian, Kapis, Svetlana, Nuguid, Theresa S, Izbicki, Jakob R., Guengoer, Cenap, Perez, Daniel R.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
The role of RANK-signaling in tumor cell proliferation and migration in pancreatic adenocarcinoma
El Gammal, Alexander T., Sander, Natalie, Foelster, Aljonna, Konczalla, Leonie, Friedenberger, Henrike, Guengoer, Cenap, Wolters-Eisfeld, Gerrit, Sreseli, Rusudan, Hofmann, Bianca T., Izbicki, Jakob Robert, Bockhorn, Maximillian, Perez, Daniel R.
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
Cancer-derived mutations in the regulatory subunit p85[alpha] of phosphoinositide 3-kinase function through the catalytic subunit p110[alpha]
Sun, Minghao, Hillmann, Petra, Hofmann, Bianca T, Hart, Jonathan R, Vogt, Peter K
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
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Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
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