Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
Hulme, Benjamin J, Geyer, Kathrin K, Forde-Thomas, Josephine E, Padalino, Gilda, Phillips, Dylan W, Ittiprasert, Wannaporn, Karinshak, Shannon E, Mann, Victoria H, Chalmers, Iain W, Brindley, Paul J, Hokke, Cornelis H, Hoffmann, Karl F
Published in PLoS pathogens (01.01.2022)
Published in PLoS pathogens (01.01.2022)
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Journal Article
Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs[S]
Smit, Cornelis H., van Diepen, Angela, Nguyen, D. Linh, Wuhrer, Manfred, Hoffmann, Karl F., Deelder, André M., Hokke, Cornelis H.
Published in Molecular & cellular proteomics (01.07.2015)
Published in Molecular & cellular proteomics (01.07.2015)
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Journal Article
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae
Gasan, Thomas A, Kuipers, Marije E, Roberts, Grisial H, Padalino, Gilda, Forde-Thomas, Josephine E, Wilson, Shona, Wawrzyniak, Jakub, Tukahebwa, Edridah M, Hoffmann, Karl F, Chalmers, Iain W
Published in PLoS neglected tropical diseases (01.11.2021)
Published in PLoS neglected tropical diseases (01.11.2021)
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Journal Article
Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni
Craven, Holly M, Bonsignore, Riccardo, Lenis, Vasilis, Santi, Nicolo, Berrar, Daniel, Swain, Martin, Whiteland, Helen, Casini, Angela, Hoffmann, Karl F
Published in PLoS neglected tropical diseases (18.02.2021)
Published in PLoS neglected tropical diseases (18.02.2021)
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Journal Article
Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni
Ittiprasert, Wannaporn, Mann, Victoria H, Karinshak, Shannon E, Coghlan, Avril, Rinaldi, Gabriel, Sankaranarayanan, Geetha, Chaidee, Apisit, Tanno, Toshihiko, Kumkhaek, Chutima, Prangtaworn, Pannathee, Mentink-Kane, Margaret M, Cochran, Christina J, Driguez, Patrick, Holroyd, Nancy, Tracey, Alan, Rodpai, Rutchanee, Everts, Bart, Hokke, Cornelis H, Hoffmann, Karl F, Berriman, Matthew, Brindley, Paul J
Published in eLife (15.01.2019)
Published in eLife (15.01.2019)
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Journal Article
Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni
Roquis, David, Taudt, Aaron, Geyer, Kathrin K, Padalino, Gilda, Hoffmann, Karl F, Holroyd, Nancy, Berriman, Matt, Aliaga, Benoît, Chaparro, Cristian, Grunau, Christoph, Augusto, Ronaldo de Carvalho
Published in PLoS pathogens (01.05.2018)
Published in PLoS pathogens (01.05.2018)
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Journal Article
Using ChEMBL to Complement Schistosome Drug Discovery
Padalino, Gilda, Coghlan, Avril, Pagliuca, Giampaolo, Forde-Thomas, Josephine E, Berriman, Matthew, Hoffmann, Karl F
Published in Pharmaceutics (28.04.2023)
Published in Pharmaceutics (28.04.2023)
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Journal Article
The diterpenoid 7-keto-sempervirol, derived from Lycium chinense, displays anthelmintic activity against both Schistosoma mansoni and Fasciola hepatica
Edwards, Jennifer, Brown, Martha, Peak, Emily, Bartholomew, Barbara, Nash, Robert J, Hoffmann, Karl F
Published in PLoS neglected tropical diseases (01.03.2015)
Published in PLoS neglected tropical diseases (01.03.2015)
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Journal Article
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
Whatley, Kezia C L, Padalino, Gilda, Whiteland, Helen, Geyer, Kathrin K, Hulme, Benjamin J, Chalmers, Iain W, Forde-Thomas, Josephine, Ferla, Salvatore, Brancale, Andrea, Hoffmann, Karl F
Published in PLoS neglected tropical diseases (01.11.2019)
Published in PLoS neglected tropical diseases (01.11.2019)
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Journal Article
Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal
Whiteland, Helen, Crusco, Alessandra, Bloemberg, Lisa W, Tibble-Howlings, Jamie, Forde-Thomas, Josephine, Coghlan, Avril, Murphy, Patrick J, Hoffmann, Karl F
Published in PLoS neglected tropical diseases (01.10.2020)
Published in PLoS neglected tropical diseases (01.10.2020)
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Journal Article
Daily rhythms in gene expression of the human parasite Schistosoma mansoni
Rawlinson, Kate A, Reid, Adam J, Lu, Zhigang, Driguez, Patrick, Wawer, Anna, Coghlan, Avril, Sankaranarayanan, Geetha, Buddenborg, Sarah K, Soria, Carmen Diaz, McCarthy, Catherine, Holroyd, Nancy, Sanders, Mandy, Hoffmann, Karl F, Wilcockson, David, Rinaldi, Gabriel, Berriman, Matthew
Published in BMC biology (02.12.2021)
Published in BMC biology (02.12.2021)
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Journal Article
Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni
Geyer, Kathrin K, Munshi, Sabrina E, Whiteland, Helen L, Fernandez-Fuentes, Narcis, Phillips, Dylan W, Hoffmann, Karl F
Published in PLoS pathogens (01.06.2018)
Published in PLoS pathogens (01.06.2018)
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Journal Article
Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni
Padalino, Gilda, Ferla, Salvatore, Brancale, Andrea, Chalmers, Iain W., Hoffmann, Karl F.
Published in International journal for parasitology -- drugs and drug resistance (01.12.2018)
Published in International journal for parasitology -- drugs and drug resistance (01.12.2018)
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Journal Article
Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni
Nowacki, Fanny C., Swain, Martin T., Klychnikov, Oleg I., Niazi, Umar, Ivens, Alasdair, Quintana, Juan F., Hensbergen, Paul J., Hokke, Cornelis H., Buck, Amy H., Hoffmann, Karl F.
Published in Journal of extracellular vesicles (01.01.2015)
Published in Journal of extracellular vesicles (01.01.2015)
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Journal Article
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Chakroborty, Anand, Pritchard, Deiniol R, Bouillon, Marc E, Cervi, Anna, Kraehenbuehl, Rolf, Wild, Charlotte, Fenn, Caroline, Holdsworth, Peter, Capner, Colin, Padalino, Gilda, Forde-Thomas, Josephine E, Payne, Joseph, Smith, Brendan G, Fisher, Maggie, Lahmann, Martina, Baird, Mark S, Hoffmann, Karl F
Published in Pharmaceutics (03.07.2023)
Published in Pharmaceutics (03.07.2023)
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Journal Article
The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni
Geyer, Kathrin K, Niazi, Umar H, Duval, David, Cosseau, Céline, Tomlinson, Chad, Chalmers, Iain W, Swain, Martin T, Cutress, David J, Bickham-Wright, Utibe, Munshi, Sabrina E, Grunau, Christoph, Yoshino, Timothy P, Hoffmann, Karl F
Published in PLoS neglected tropical diseases (16.05.2017)
Published in PLoS neglected tropical diseases (16.05.2017)
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Journal Article
Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses
Fitzpatrick, Jennifer M, Peak, Emily, Perally, Samirah, Chalmers, Iain W, Barrett, John, Yoshino, Timothy P, Ivens, Alasdair C, Hoffmann, Karl F
Published in PLoS neglected tropical diseases (01.11.2009)
Published in PLoS neglected tropical diseases (01.11.2009)
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Journal Article
Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family
Chalmers, Iain W, McArdle, Andrew J, Coulson, Richard Mr, Wagner, Marissa A, Schmid, Ralf, Hirai, Hirohisa, Hoffmann, Karl F
Published in BMC genomics (23.02.2008)
Published in BMC genomics (23.02.2008)
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