Effects of hepatic impairment on the steady-state pharmacokinetics of etravirine 200 mg BID: An open-label, multiple-dose, controlled Phase I study in adults
Schöller-Gyüre, Monika, MD, Kakuda, Thomas N., PharmD, Smedt, Goedele De, MD, Woodfall, Brian, MD, Berckmans, Cindy, MSc, Peeters, Monika, MSc, Hoetelmans, Richard M.W., PhD
Published in Clinical therapeutics (01.02.2010)
Published in Clinical therapeutics (01.02.2010)
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Clinical Pharmacokinetics and Pharmacodynamics of Etravirine
Schöller-Gyüre, Monika, Kakuda, Thomas N., Raoof, Araz, De Smedt, Goedele, Hoetelmans, Richard M. W.
Published in Clinical pharmacokinetics (01.01.2009)
Published in Clinical pharmacokinetics (01.01.2009)
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The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects
Kakuda, Thomas N, Van Solingen-Ristea, Rodica M, Onkelinx, Joelle, Stevens, Tanja, Aharchi, Fatima, De Smedt, Goedele, Peeters, Monika, Leopold, Lorant, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.04.2014)
Published in Journal of clinical pharmacology (01.04.2014)
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Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two-way crossover trial
Kakuda, Thomas N, Leopold, Lorant, Nijs, Steven, Vandevoorde, Ann, Crauwels, Herta M, Bertelsen, Kirk M, Stevens, Marita, Witek, James, van Delft, Yvon, Tomaka, Frank, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.05.2014)
Published in Journal of clinical pharmacology (01.05.2014)
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The effect of rilpivirine on the pharmacokinetics of methadone in HIV-negative volunteers
Crauwels, Herta M, van Heeswijk, Rolf P G, Vandevoorde, Ann, Buelens, Annemie, Stevens, Marita, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.02.2014)
Published in Journal of clinical pharmacology (01.02.2014)
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The effect of different meal types on the pharmacokinetics of darunavir (TMC114)/ritonavir in HIV-negative healthy volunteers
Sekar, Vanitha, Kestens, Dries, Spinosa-Guzman, Sabrina, De Pauw, Martine, De Paepe, Els, Vangeneugden, Tony, Lefebvre, Eric, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.04.2007)
Published in Journal of clinical pharmacology (01.04.2007)
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Pharmacokinetics of Multiple-Dose Darunavir in Combination with Low-Dose Ritonavir in Individuals with Mild-to-Moderate Hepatic Impairment
Sekar, Vanitha, Spinosa-Guzman, Sabrina, De Paepe, Els, Stevens, Tanja, Tomaka, Frank, De Pauw, Martine, Hoetelmans, Richard M. W.
Published in Clinical pharmacokinetics (01.05.2010)
Published in Clinical pharmacokinetics (01.05.2010)
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Effect of steady-state etravirine on the pharmacokinetics and pharmacodynamics of ethinylestradiol and norethindrone
Schöller-Gyüre, Monika, Kakuda, Thomas N, Woodfall, Brian, Aharchi, Fatima, Peeters, Monika, Vandermeulen, Kati, Hoetelmans, Richard M.W
Published in Contraception (Stoneham) (01.07.2009)
Published in Contraception (Stoneham) (01.07.2009)
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The effect of plasma drug concentrations on HIV-1 clearance rate during quadruple drug therapy
HOETELMANS, R. M. W, REIJERS, M. H. E, SCHUITEMAKER, H, DE WOLF, F, BEIJNEN, J. H, LANGE, J. M. A, WEVERLING, G. J, TEN KATE, R. W, WIT, F. W. N. M, MULDER, J. W, WEIGEL, H. M, FRISSEN, P. H. J, ROOS, M, JURRIAANS, S
Published in AIDS (London) (30.07.1998)
Published in AIDS (London) (30.07.1998)
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Mechanistic Model Describing the Time Course of Humoral Immunity Following Ad26.COV2.S Vaccination in Non-Human Primates
Dari, Anna, Solforosi, Laura, Roozendaal, Ramon, Hoetelmans, Richard M W, Pérez-Ruixo, Juan-José, Boulton, Muriel
Published in The Journal of pharmacology and experimental therapeutics (01.10.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2023)
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Sensitive liquid chromatographic assay for amprenavir, a human immunodeficiency virus protease inhibitor, in human plasma, cerebrospinal fluid and semen
Sparidans, Rolf W, Hoetelmans, Richard M.W, Beijnen, Jos H
Published in Journal of chromatography. B, Biomedical sciences and applications (26.05.2000)
Published in Journal of chromatography. B, Biomedical sciences and applications (26.05.2000)
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Quantifying Antibody Persistence After a Single Dose of COVID‐19 Vaccine Ad26.COV2.S in Humans Using a Mechanistic Modeling and Simulation Approach
Dari, Anna, Boulton, Muriel, Neyens, Martine, Le Gars, Mathieu, Valenzuela, Belén, Shukarev, Georgi, Cárdenas, Vicky, Ruiz‐Guiñazú, Javier, Sadoff, Jerald, Hoetelmans, Richard M. W., Ruixo, Juan José Pérez
Published in Clinical pharmacology and therapeutics (01.02.2023)
Published in Clinical pharmacology and therapeutics (01.02.2023)
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Pharmacokinetics of darunavir in fixed-dose combination with cobicistat compared with coadministration of darunavir and ritonavir as single agents in healthy volunteers
Kakuda, Thomas N, Opsomer, Magda, Timmers, Maarten, Iterbeke, Koen, Van De Casteele, Tom, Hillewaert, Vera, Petrovic, Romana, Hoetelmans, Richard M W
Published in Journal of clinical pharmacology (01.08.2014)
Published in Journal of clinical pharmacology (01.08.2014)
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Single‐ and multiple‐dose pharmacokinetics and safety of pimodivir, a novel, non‐nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open‐label study in healthy volunteers
Deleu, Sofie, Kakuda, Thomas N., Spittaels, Kurt, Vercauteren, Jurgen J., Hillewaert, Vera, Lwin, Amy, Leopold, Lorant, Hoetelmans, Richard M. W.
Published in British journal of clinical pharmacology (01.11.2018)
Published in British journal of clinical pharmacology (01.11.2018)
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Bioequivalence of a darunavir/cobicistat fixed-dose combination tablet versus single agents and food effect in healthy volunteers
Kakuda, Thomas N, Van De Casteele, Tom, Petrovic, Romana, Neujens, Mark, Salih, Hiba, Opsomer, Magda, Hoetelmans, Richard Mw
Published in Antiviral therapy (01.01.2014)
Published in Antiviral therapy (01.01.2014)
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