Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F, Knott, Maximilian M L, Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L B, Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S, Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C, Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D, Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G P
Published in Nature communications (11.09.2019)
Published in Nature communications (11.09.2019)
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Journal Article
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F, Knott, Maximilian M L, Colombo, Maria V, Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S, Li, Jing, Stein, Stefanie, Gerke, Julia S, Baldauf, Michaela C, Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L B, Amatruda, James F, Cossarizza, Andrea, Henssen, Anton G, Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G P
Published in Nature communications (15.05.2020)
Published in Nature communications (15.05.2020)
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Journal Article
Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies
Knott, Maximilian M. L., Hölting, Tilman L. B., Ohmura, Shunya, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G. P.
Published in Cancer and metastasis reviews (01.12.2019)
Published in Cancer and metastasis reviews (01.12.2019)
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Journal Article
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Ohmura, Shunya, Marchetto, Aruna, Orth, Martin F, Li, Jing, Jabar, Susanne, Ranft, Andreas, Vinca, Endrit, Ceranski, Katharina, Carreño-Gonzalez, Martha J, Romero-Pérez, Laura, Wehweck, Fabienne S, Musa, Julian, Bestvater, Felix, Knott, Maximilian M L, Hölting, Tilman L B, Hartmann, Wolfgang, Dirksen, Uta, Kirchner, Thomas, Cidre-Aranaz, Florencia, Grünewald, Thomas G P
Published in Molecular cancer (27.07.2021)
Published in Molecular cancer (27.07.2021)
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Journal Article
Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma
Gerke, Julia S., Orth, Martin F., Tolkach, Yuri, Romero‐Pérez, Laura, Wehweck, Fabienne S., Stein, Stefanie, Musa, Julian, Knott, Maximilian M.L., Hölting, Tilman L.B., Li, Jing, Sannino, Giuseppina, Marchetto, Aruna, Ohmura, Shunya, Cidre‐Aranaz, Florencia, Müller‐Nurasyid, Martina, Strauch, Konstantin, Stief, Christian, Kristiansen, Glen, Kirchner, Thomas, Buchner, Alexander, Grünewald, Thomas G.P.
Published in International journal of cancer (01.04.2020)
Published in International journal of cancer (01.04.2020)
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Journal Article
Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Hölting, Tilman L B, Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J, Funk, Cornelius M, Geyer, Florian H, Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L, Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Künkele, Annette, Klauschen, Frederick, Grünewald, Thomas G P, Knott, Maximilian M L
Published in Molecular cancer (13.10.2022)
Published in Molecular cancer (13.10.2022)
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Journal Article
Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma
Cidre-Aranaz, Florencia, Li, Jing, Hölting, Tilman L B, Orth, Martin F, Imle, Roland, Kutschmann, Stefanie, Ammirati, Giulia, Ceranski, Katharina, Carreño-Gonzalez, Martha Julia, Kasan, Merve, Marchetto, Aruna, Funk, Cornelius M, Bestvater, Felix, Bersini, Simone, Arrigoni, Chiara, Moretti, Matteo, Thiel, Uwe, Baumhoer, Daniel, Sahm, Felix, Pfister, Stefan M, Hartmann, Wolfgang, Dirksen, Uta, Romero-Pérez, Laura, Banito, Ana, Ohmura, Shunya, Musa, Julian, Kirchner, Thomas, Knott, Maximilian M L, Grünewald, Thomas G P
Published in Molecular cancer (03.01.2022)
Published in Molecular cancer (03.01.2022)
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Journal Article
Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma
Orth, Martin F., Gerke, Julia S., Knösel, Thomas, Altendorf‐Hofmann, Annelore, Musa, Julian, Alba‐Rubio, Rebeca, Stein, Stefanie, Hölting, Tilman L. B., Cidre‐Aranaz, Florencia, Romero‐Pérez, Laura, Dallmayer, Marlene, Baldauf, Michaela C., Marchetto, Aruna, Sannino, Giuseppina, Knott, Maximilian M. L., Wehweck, Fabienne, Ohmura, Shunya, Li, Jing, Hakozaki, Michiyuki, Kirchner, Thomas, Dandekar, Thomas, Butt, Elke, Grünewald, Thomas G. P.
Published in International journal of cancer (15.02.2019)
Published in International journal of cancer (15.02.2019)
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Journal Article
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma
Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela C, Hölting, Tilman L B, Musa, Julian, Knott, Max M L, Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S, Romero-Pérez, Laura, Gerke, Julia S, Orth, Martin F, Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas G P
Published in Cell death & disease (11.02.2019)
Published in Cell death & disease (11.02.2019)
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Journal Article
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
Orth, Martin F, Hölting, Tilman L B, Dallmayer, Marlene, Wehweck, Fabienne S, Paul, Tanja, Musa, Julian, Baldauf, Michaela C, Surdez, Didier, Delattre, Olivier, Knott, Maximilian M L, Romero-Pérez, Laura, Kasan, Merve, Cidre-Aranaz, Florencia, Gerke, Julia S, Ohmura, Shunya, Li, Jing, Marchetto, Aruna, Henssen, Anton G, Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Kanaseki, Takayuki, Bertram, Stefanie, Dirksen, Uta, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G P
Published in Cancers (10.03.2020)
Published in Cancers (10.03.2020)
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Journal Article
Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients
Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.
Published in EBioMedicine (01.09.2019)
Published in EBioMedicine (01.09.2019)
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Journal Article
Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
Hoelting, Tilman L B, Cidre-Aranaz, Florencia, Matzek, Dana, Popper, Bastian, Jacobi, Severin J, Li, Jing, Piseddu, Ignazio, Cadilha, Bruno L, Ledderose, Stephan, Zwilling, Jennifer, Ohmura, Shunya, Anz, David, Kuenkele, Annette, Klauschen, Frederick, Gruenewald, Thomas G P, Knott, Maximilian M L
Published in bioRxiv (05.01.2022)
Published in bioRxiv (05.01.2022)
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Paper
Chromosome 8 gain drives poor patient outcome via expression of 4E-BP1 in Ewing sarcoma
Funk, Cornelius M, Orth, Martin F, Aljakouch, Karim, Ehlers, Anna, Li, Jing, Hoelting, Tilman L B, Will, Rainer, Willis, Franziska, Endrit Vinca, Ohmura, Shunya, Imle, Roland, Knott, Maximilian M L, Zahnow, Felina, Sastre, Ana, Alonso, Javier, Sahm, Felix, Schneider, Martin, Banito, Ana, Leprivier, Gabriel, Hartmann, Wolfgang, Dirksen, Uta, Witt, Olaf, Oehme, Ina, Pfister, Stefan M, Romero-Perez, Laura, Krijgsveld, Jeroen, Cidre-Aranaz, Florencia, Gruenewald, Thomas G P, Musa, Julian
Published in bioRxiv (14.12.2022)
Published in bioRxiv (14.12.2022)
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Paper
Oncogenic hijacking of a developmental transcription factor evokes therapeutic vulnerability for ROS-induction in Ewing sarcoma
Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F, Li, Jing, Wehweck, Fabienne S, Knott, Maximilian M L, Stein, Stefanie, Saucier, David, Arrigoni, Chiara, Gerke, Julia S, Baldauf, Michaela C, Musa, Julian, Dallmayer, Marlene, Hoelting, Tilman L B, Moretti, Matteo, Amatruda, James F, Romero-Perez, Laura, Cidre-Aranaz, Florencia, Kirchner, Thomas, Sannino, Giuseppina, Grunewald, Thomas G P
Published in bioRxiv (14.03.2019)
Published in bioRxiv (14.03.2019)
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Paper
Biomarker-based outcome prediction in prostate adenocarcinoma depends on the TMPRSS2-ERG status
Gerke, Julia S, Orth, Martin F, Tolkach, Yuri, Romero-Perez, Laura, Wehweck, Fabienne S, Stein, Stefanie, Musa, Julian, Knott, Maximilian M L, Hoelting, Tilman L B, Li, Jing, Sannino, Giuseppina, Marchetto, Aruna, Ohmura, Shunya, Cidre-Aranaz, Florencia, Mueller-Nurasyid, Martina, Strauch, Konstantin, Stief, Christian, Kristiansen, Glen, Kirchner, Thomas, Buchner, Alexander, Grunewald, Thomas G P
Published in bioRxiv (10.02.2019)
Published in bioRxiv (10.02.2019)
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Paper
Targeting the CALCB/RAMP1-axis inhibits growth of Ewing sarcoma
Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba-Rubio, Rebeca, Baldauf, Michaela C, Hoelting, Tilman L B, Musa, Julian, Knott, Maximilian M L, Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S, Romero-Perez, Laura, Gerke, Julia S, Orth, Martin F, Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grunewald, Thomas G P
Published in bioRxiv (08.12.2018)
Published in bioRxiv (08.12.2018)
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Paper
Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer
Musa, Julian, Cidre-Aranaz, Florencia, Marie-Ming Aynaud, Orth, Martin F, Mirabeau, Olivier, Varon, Mor, Grossetete, Sandrine, Surdez, Didier, Ohmura, Shunya, Gerke, Julia S, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C, Gartlgruber, Moritz, Westermann, Frank, Stein, Stefanie, Hoelting, Tilman L B, Knott, Maximilian, Sannino, Giuseppina, Li, Jing, Romero-Perez, Laura, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D, Shlien, Adam, Barak Rotblat, Kirchner, Thomas, Delattre, Olivier, Grunewald, Thomas G P
Published in bioRxiv (27.12.2018)
Published in bioRxiv (27.12.2018)
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Paper
SOX2 expression identifies Ewing sarcoma patients with high risk for tumor relapse and poor survival
Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S, Kiran, Merve M, Hoelting, Tilman L B, Musa, Julian, Romero-Perez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M L, Li, Jing, Juergens, Heribert, Sastre, Ana, Alonso, Javier, Wilian Da Silveira, Hardiman, Gary, Gerke, Julia S, Orth, Martin F, Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grunewald, Thomas G P
Published in bioRxiv (17.12.2018)
Published in bioRxiv (17.12.2018)
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