Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis
Hargrove, Tatiana Y., Friggeri, Laura, Wawrzak, Zdzislaw, Qi, Aidong, Hoekstra, William J., Schotzinger, Robert J., York, John D., Guengerich, F. Peter, Lepesheva, Galina I.
Published in The Journal of biological chemistry (21.04.2017)
Published in The Journal of biological chemistry (21.04.2017)
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Journal Article
Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity
Hargrove, Tatiana Y, Garvey, Edward P, Hoekstra, William J, Yates, Christopher M, Wawrzak, Zdzislaw, Rachakonda, Girish, Villalta, Fernando, Lepesheva, Galina I
Published in Antimicrobial agents and chemotherapy (01.07.2017)
Published in Antimicrobial agents and chemotherapy (01.07.2017)
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In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans
Nishimoto, Andrew T, Wiederhold, Nathan P, Flowers, Stephanie A, Zhang, Qing, Kelly, Steven L, Morschhäuser, Joachim, Yates, Christopher M, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P, Rogers, P David
Published in Antimicrobial agents and chemotherapy (01.06.2019)
Published in Antimicrobial agents and chemotherapy (01.06.2019)
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Journal Article
The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii
Lockhart, Shawn R, Fothergill, Annette W, Iqbal, Naureen, Bolden, Carol B, Grossman, Nina T, Garvey, Edward P, Brand, Stephen R, Hoekstra, William J, Schotzinger, Robert J, Ottinger, Elizabeth, Patterson, Thomas F, Wiederhold, Nathan P
Published in Antimicrobial agents and chemotherapy (01.04.2016)
Published in Antimicrobial agents and chemotherapy (01.04.2016)
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Journal Article
Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161
Nishimoto, Andrew T, Whaley, Sarah G, Wiederhold, Nathan P, Zhang, Qing, Yates, Christopher M, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P, Rogers, P David
Published in Antimicrobial agents and chemotherapy (01.10.2019)
Published in Antimicrobial agents and chemotherapy (01.10.2019)
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Journal Article
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme
Warrilow, Andrew G S, Parker, Josie E, Price, Claire L, Nes, W David, Garvey, Edward P, Hoekstra, William J, Schotzinger, Robert J, Kelly, Diane E, Kelly, Steven L
Published in Antimicrobial agents and chemotherapy (01.08.2016)
Published in Antimicrobial agents and chemotherapy (01.08.2016)
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Journal Article
VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans
Break, Timothy J, Desai, Jigar V, Natarajan, Mukil, Ferre, Elise M N, Henderson, Christina, Zelazny, Adrian M, Siebenlist, Ulrich, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P, Lionakis, Michail S
Published in Journal of antimicrobial chemotherapy (01.01.2018)
Published in Journal of antimicrobial chemotherapy (01.01.2018)
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Journal Article
VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection
Gebremariam, Teclegiorgis, Wiederhold, Nathan P, Fothergill, Annette W, Garvey, Edward P, Hoekstra, William J, Schotzinger, Robert J, Patterson, Thomas F, Filler, Scott G, Ibrahim, Ashraf S
Published in Antimicrobial agents and chemotherapy (01.12.2015)
Published in Antimicrobial agents and chemotherapy (01.12.2015)
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Journal Article
Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection
Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Lin, Lin, Wiederhold, Nathan P, Garvey, Edward P, Hoekstra, William J, Schotzinger, Robert J, Patterson, Thomas F, Filler, Scott G, Ibrahim, Ashraf S
Published in Antimicrobial agents and chemotherapy (01.09.2017)
Published in Antimicrobial agents and chemotherapy (01.09.2017)
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Journal Article
In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy
Wiederhold, Nathan P, Xu, Xin, Wang, Amy, Najvar, Laura K, Garvey, Edward P, Ottinger, Elizabeth A, Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J, Brand, Stephen R, Schotzinger, Robert J, Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R, Patterson, Thomas F
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Published in Antimicrobial agents and chemotherapy (01.11.2018)
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Journal Article
Efficacy of the Investigational Antifungal VT-1161 in Treating Naturally Occurring Coccidioidomycosis in Dogs
Shubitz, Lisa F, Roy, Michael E, Trinh, Hien T, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P
Published in Antimicrobial agents and chemotherapy (01.05.2017)
Published in Antimicrobial agents and chemotherapy (01.05.2017)
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Journal Article
Activity of VT-1129 against Cryptococcus neoformans clinical isolates with high fluconazole MICs
Nielsen, Kirsten, Vedula, Priya, Smith, Kyle D, Meya, David B, Garvey, Edward P, Hoekstra, William J, Schotzinger, Robert J, Boulware, David R
Published in Medical mycology (Oxford) (01.06.2017)
Published in Medical mycology (Oxford) (01.06.2017)
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Journal Article
Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors
Sparks, Steven M, Danger, Dana P, Hoekstra, William J, Leesnitzer, Tony, Schotzinger, Robert J, Yates, Christopher M, Becherer, J. David
Published in ACS medicinal chemistry letters (11.07.2019)
Published in ACS medicinal chemistry letters (11.07.2019)
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Journal Article
The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis
Wiederhold, Nathan P, Najvar, Laura K, Garvey, Edward P, Brand, Stephen R, Xu, Xin, Ottinger, Elizabeth A, Alimardanov, Asaf, Cradock, Jim, Behnke, Mark, Hoekstra, William J, Schotzinger, Robert J, Jaramillo, Rosie, Olivo, Marcos, Kirkpatrick, William R, Patterson, Thomas F
Published in Antimicrobial agents and chemotherapy (01.09.2018)
Published in Antimicrobial agents and chemotherapy (01.09.2018)
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Journal Article
Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models
Shubitz, Lisa F, Trinh, Hien T, Galgiani, John N, Lewis, Maria L, Fothergill, Annette W, Wiederhold, Nathan P, Barker, Bridget M, Lewis, Eric R G, Doyle, Adina L, Hoekstra, William J, Schotzinger, Robert J, Garvey, Edward P
Published in Antimicrobial agents and chemotherapy (01.12.2015)
Published in Antimicrobial agents and chemotherapy (01.12.2015)
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Journal Article
The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51
Warrilow, Andrew G S, Parker, Josie E, Price, Claire L, Garvey, Edward P, Hoekstra, William J, Schotzinger, Robert J, Wiederhold, Nathan P, Nes, W David, Kelly, Diane E, Kelly, Steven L
Published in Antimicrobial agents and chemotherapy (01.07.2017)
Published in Antimicrobial agents and chemotherapy (01.07.2017)
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Journal Article
Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi
Hoekstra, William J, Hargrove, Tatiana Y, Wawrzak, Zdzislaw, da Gama Jaen Batista, Denise, da Silva, Cristiane F, Nefertiti, Aline S G, Rachakonda, Girish, Schotzinger, Robert J, Villalta, Fernando, Soeiro, Maria de Nazaré C, Lepesheva, Galina I
Published in Antimicrobial agents and chemotherapy (01.02.2016)
Published in Antimicrobial agents and chemotherapy (01.02.2016)
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