Pharmacological characterization of GSK1004723, a novel, long‐acting antagonist at histamine H 1 and H 3 receptors
Slack, RJ, Russell, LJ, Hall, DA, Luttmann, MA, Ford, AJ, Saunders, KA, Hodgson, ST, Connor, HE, Browning, C, Clark, KL
Published in British journal of pharmacology (01.11.2011)
Published in British journal of pharmacology (01.11.2011)
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Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction
Fryer, Allison D, Stein, Louis H, Nie, Zhenying, Curtis, Damian E, Evans, Christopher M, Hodgson, Simon T, Jose, Peter J, Belmonte, Kristen E, Fitch, Erin, Jacoby, David B
Published in The Journal of clinical investigation (01.01.2006)
Published in The Journal of clinical investigation (01.01.2006)
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Pharmacological characterization of GSK1004723, a novel, long‐acting antagonist at histamine H1 and H3 receptors
Slack, RJ, Russell, LJ, Hall, DA, Luttmann, MA, Ford, AJ, Saunders, KA, Hodgson, ST, Connor, HE, Browning, C, Clark, KL
Published in British journal of pharmacology (01.11.2011)
Published in British journal of pharmacology (01.11.2011)
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Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)
Macdonald, Simon J. F, Dowle, Michael D, Harrison, Lee A, Clarke, Geoffrey D. E, Inglis, Graham G. A, Johnson, Martin R, Shah, Pritom, Smith, Robin A, Amour, Augustin, Fleetwood, Gill, Humphreys, Davina C, Molloy, Christopher R, Dixon, Mary, Godward, Rosalind E, Wonacott, Alan J, Singh, Onkar M. P, Hodgson, Simon T, Hardy, George W
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine
YOUNG, R. J, BEAMS, R. M, FRENCH, C, HODGSON, S. T, HODSON, H. F, KLEANTHOUS, S, RIDER, P, SANDERS, D, SAWYER, D. A, SCOTT, K. J, SHEARER, B. G, STOCKER, R, CARTER, K, SMITH, S, TACKLEY, M. C, KNOWLES, R. G, CLARK, H. A. R, COE, D. M, CHAMBERS, C. L, DAVIES, P. I, DAWSON, J, DRYSDALE, M. J, FRANZMAN, K. W
Published in Bioorganic & medicinal chemistry letters (20.03.2000)
Published in Bioorganic & medicinal chemistry letters (20.03.2000)
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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
Macdonald, Simon J.F, Dowle, Michael D, Harrison, Lee A, Shah, Pritom, Johnson, Martin R, Inglis, Graham G.A, Clarke, Geoffrey D.E, Smith, Robin A, Humphreys, Davina, Molloy, Christopher R, Amour, Augustin, Dixon, Mary, Murkitt, Graham, Godward, Rosalind E, Padfield, Tony, Skarzynski, Tadeusz, Singh, Onkar M.P, Kumar, K.Abhhilash, Fleetwood, Gill, Hodgson, Simon T, Hardy, George W, Finch, Harry
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
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A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology
Macdonald, Simon J. F, Clarke, Geoffrey D. E, Dowle, Michael D, Harrison, Lee A, Hodgson, Simon T, Inglis, Graham G. A, Johnson, Martin R, Shah, Prit, Upton, Richard J, Walls, Steven B
Published in Journal of organic chemistry (09.07.1999)
Published in Journal of organic chemistry (09.07.1999)
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Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams
MACDONALD, Simon J. F, DOWLE, Michael D, MOLLOY, Christopher R, DIXON, Mary, MURKITT, Graham, GODWARD, Rosalind E, SKARZYNSKI, Tadeusz, SINGH, Onkar M. P, KUMAR, K. Abhhilash, HODGSON, Simon T, MCDONALD, Edward, HARDY, George W, HARRISON, Lee A, FINCH, Harry, SPOONER, Julie E, SHAH, Pritom, JOHNSON, Martin R, INGLIS, Graham G. A, CLARKE, Geoffrey D. E, BELTON, David J, SMITH, Robin A
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Structure–Activity Relationship for Two Lipoxygenase Inhibitors and Their Potential for Inducing Nephrotic Syndrome
Morley, Timothy J., Evans, Gareth O., Goodwin, David A., Read, Nicholas G., Hodgson, Simon T., Hawksworth, Gabrielle M.
Published in Toxicology and applied pharmacology (01.10.1997)
Published in Toxicology and applied pharmacology (01.10.1997)
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Design and synthesis of achiral 5-lipoxygenase inhibitors employing the cyclobutyl group
Hodgson, Simon T., Wates, Peter J., Blackwell, Geoffrey J., Craig, Caroline, Yeadon, Michael, Boughton-Smith, Nigel
Published in Bioorganic & medicinal chemistry letters (01.12.1993)
Published in Bioorganic & medicinal chemistry letters (01.12.1993)
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Synthesis of β-lactams from π-allyltricarbonyliron(lactone) complexes
ANNIS, G. D, HEBBLETHWAITE, E. M, HODGSON, S. T, HOLLINSHEAD, D. M, LEY, S. V
Published in J. Chem. Soc., Perkin Trans. 1 (1983)
Published in J. Chem. Soc., Perkin Trans. 1 (1983)
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USE OF PI-ALLYLTRICARBONYLIRON LACTAM COMPLEXES IN THE PREPARATION OF NOCARDICIN DERIVATIVES - SYNTHESIS OF (-)-3-OXO-1-[(PARA-BENZYLOXYPHENYL)-BENZYLOXYCARBONYLMETHYL]AZETIDIN-2-ONE
HODGSON, ST, HOLLINSHEAD, DM, LEY, SV, LOW, CMR, WILLIAMS, DJ
Published in J. Chem. Soc., Perkin Trans. 1 (01.01.1985)
Published in J. Chem. Soc., Perkin Trans. 1 (01.01.1985)
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