Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy
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Published in Journal of medicinal chemistry (26.08.2010)
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MMP-13 selective isonipecotamide α-sulfone hydroxamates
Kolodziej, Stephen A., Hockerman, Susan L., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Stehle, Nathan, Swearingen, Craig, Becker, Daniel P.
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Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates
Kolodziej, Stephen A., Hockerman, Susan L., Boehm, Terri L., Carroll, Jeffery N., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Rico, Joseph G., Stehle, Nathan W., Swearingen, Craig, Becker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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MMP-13 selective α-sulfone hydroxamates: A survey of P1′ heterocyclic amide isosteres
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Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Chemical Library Purification Strategies Based on Principles of Complementary Molecular Reactivity and Molecular Recognition
Flynn, Daniel L, Crich, Joyce Z, Devraj, Rajesh V, Hockerman, Susan L, Parlow, John J, South, Michael S, Woodard, Scott
Published in Journal of the American Chemical Society (28.05.1997)
Published in Journal of the American Chemical Society (28.05.1997)
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α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1
Becker, Daniel P, Barta, Thomas E, Bedell, Louis, DeCrescenzo, Gary, Freskos, John, Getman, Daniel P, Hockerman, Susan L, Li, Madeleine, Mehta, Pramod, Mischke, Brent, Munie, Grace E, Swearingen, Craig, Villamil, Clara I
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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α-Alkyl-α-amino-β-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1
Becker, Daniel P, DeCrescenzo, Gary, Freskos, John, Getman, Daniel P, Hockerman, Susan L, Li, Madeleine, Mehta, Pramod, Munie, Grace E, Swearingen, Craig
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals
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Published in The Journal of experimental medicine (07.05.2018)
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Discovery of (3 S ,3a R )-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2 H -benzo[ g ]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy
Meyers, Marvin J., Arhancet, Graciela B., Hockerman, Susan L., Chen, Xiangyang, Long, Scott A., Mahoney, Matthew W., Rico, Joseph R., Garland, Danny J., Blinn, James. R., Collins, Joe T., Yang, Shengtian, Huang, Horng-Chih, McGee, Kevin F., Wendling, Jay M., Dietz, Jessica D., Payne, Maria A., Homer, Bruce L., Heron, Marcia I., Reitz, David B., Hu, Xiao
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201
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Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease
Becker, Daniel P, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, Bond, Brian R, Carroll, Jeffery, Carron, Chris P, DeCrescenzo, Gary A, Easton, Alan M, Freskos, John N, Funckes-Shippy, Chris L, Heron, Marcia, Hockerman, Susan, Howard, Carol Pearcy, Kiefer, James R, Li, Madeleine H, Mathis, Karl J, McDonald, Joseph J, Mehta, Pramod P, Munie, Grace E, Sunyer, Teresa, Swearingen, Craig A, Villamil, Clara I, Welsch, Dean, Williams, Jennifer M, Yu, Ying, Yao, Jun
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Published in Journal of medicinal chemistry (23.09.2010)
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치환된 피롤로피리미딘 JAK 억제제 및 이의 제조 및 사용 방법
JACOBSEN ERIC JON, ANDERSON DAVID RANDOLPH, HOCKERMAN SUSAN LANDIS, BLINN JAMES ROBERT
Year of Publication 08.07.2020
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ITK HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
JACOBSEN ERIC JON, HOCKERMAN SUSAN K, SPRINGER JOHN ROBERT, BLINN JAMES ROBERT
Year of Publication 13.09.2017
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Year of Publication 13.09.2017
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SUBSTITUTED PYROOLOPYRIDINES AND PYRROLOPYRAZINES FOR TREATING CANCER OR INFLAMMATORY DISEASES
JACOBSEN ERIC JON, HOCKERMAN SUSAN L, SPRINGER JOHN ROBERT, BLINN JAMES ROBERT
Year of Publication 05.09.2016
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Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy
Becker, Daniel P, Villamil, Clara I, Barta, Thomas E, Bedell, Louis J, Boehm, Terri L, DeCrescenzo, Gary A, Freskos, John N, Getman, Daniel P, Hockerman, Susan, Heintz, Robert, Howard, Susan Carol, Li, Madeleine H, McDonald, Joseph J, Carron, Chris P, Funckes-Shippy, Chris L, Mehta, Pramod P, Munie, Grace E, Swearingen, Craig A
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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