A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Hyer, Marc L, Milhollen, Michael A, Ciavarri, Jeff, Fleming, Paul, Traore, Tary, Sappal, Darshan, Huck, Jessica, Shi, Judy, Gavin, James, Brownell, Jim, Yang, Yu, Stringer, Bradley, Griffin, Robert, Bruzzese, Frank, Soucy, Teresa, Duffy, Jennifer, Rabino, Claudia, Riceberg, Jessica, Hoar, Kara, Lublinsky, Anya, Menon, Saurabh, Sintchak, Michael, Bump, Nancy, Pulukuri, Sai M, Langston, Steve, Tirrell, Stephen, Kuranda, Mike, Veiby, Petter, Newcomb, John, Li, Ping, Wu, Jing Tao, Powe, Josh, Dick, Lawrence R, Greenspan, Paul, Galvin, Katherine, Manfredi, Mark, Claiborne, Chris, Amidon, Benjamin S, Bence, Neil F
Published in Nature medicine (01.02.2018)
Published in Nature medicine (01.02.2018)
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Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J
Published in Clinical cancer research (15.12.2011)
Published in Clinical cancer research (15.12.2011)
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Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia
Jiang, Lei, Park, Ji-Sun, Yin, Ling, Laureano, Rodrigo, Jacquinet, Eric, Yang, Jinsong, Liang, Shi, Frassetto, Andrea, Zhuo, Jenny, Yan, Xinhua, Zhu, Xuling, Fortucci, Steven, Hoar, Kara, Mihai, Cosmin, Tunkey, Christopher, Presnyak, Vlad, Benenato, Kerry E., Lukacs, Christine M., Martini, Paolo G. V., Guey, Lin T.
Published in Nature communications (21.10.2020)
Published in Nature communications (21.10.2020)
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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
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MLN8054, a Small-Molecule Inhibitor of Aurora A, Causes Spindle Pole and Chromosome Congression Defects Leading to Aneuploidy
Hoar, Kara, Chakravarty, Arijit, Rabino, Claudia, Wysong, Deborah, Bowman, Douglas, Roy, Natalie, Ecsedy, Jeffrey A.
Published in Molecular and Cellular Biology (01.06.2007)
Published in Molecular and Cellular Biology (01.06.2007)
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MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo
Huck, Jessica J, Zhang, Mengkun, McDonald, Alice, Bowman, Doug, Hoar, Kara M, Stringer, Bradley, Ecsedy, Jeffery, Manfredi, Mark G, Hyer, Marc L
Published in Molecular cancer research (01.03.2010)
Published in Molecular cancer research (01.03.2010)
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Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes
VONDERHEIDE, Robert H, DOMCHEK, Susan M, ANDERSON, Karen S, HAHN, William C, NADLER, Lee M, SCHULTZE, Joachim L, GEORGE, Daniel J, HOAR, Kara M, CHEN, Dih-Yih, STEPHANS, Katherine F, MASUTOMI, Kenkichi, LODA, Massimo, ZHINAN XIA
Published in Clinical cancer research (01.02.2004)
Published in Clinical cancer research (01.02.2004)
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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway
Gavin, James M., Hoar, Kara, Xu, Qing, Ma, Jingya, Lin, Yafang, Chen, Jiejin, Chen, Wei, Bruzzese, Frank J., Harrison, Sean, Mallender, William D., Bump, Nancy J., Sintchak, Michael D., Bence, Neil F., Li, Ping, Dick, Lawrence R., Gould, Alexandra E., Chen, Jesse J.
Published in The Journal of biological chemistry (15.08.2014)
Published in The Journal of biological chemistry (15.08.2014)
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Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform
Blackburn, Christopher, Barrett, Cynthia, Brunson, Mable, Chin, Janice, England, Dylan, Garcia, Kris, Gigstad, Kenneth, Gould, Alexandra, Gutierrez, Juan, Hoar, Kara, Rowland, R. Scott, Tsu, Christopher, Ringeling, John, Wager, Krista, Xu, He
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
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Melanoma Inhibitor of Apoptosis Protein (ML-IAP) Is a Target for Immune-Mediated Tumor Destruction
Schmollinger, Jan C., Vonderheide, Robert H., Hoar, Kara M., Maecker, Britta, Schultze, Joachim L., Hodi, F. Stephen, Soiffer, Robert J., Jung, Ken, Kuroda, Marcelo J., Letvin, Norman L., Greenfield, Edward A., Mihm, Martin, Kutok, Jeffery L., Dranoff, Glenn
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2003)
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Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals
VONDERHEIDE, Robert H, SCHULTZE, Joachim L, SCHNIPPER, Deborah R, BROOKS, Mary W, LETVIN, Norman L, STEPHANS, Katherine F, WUCHERPFENNIG, Kai W, HAHN, William C, NADLER, Lee M, ANDERSON, Karen S, MAECKER, Britta, BUTLER, Marcus O, ZHINAN XIA, KURODA, Marcelo J, VON BERGWELT-BAILDON, Michael S, BEDOR, Michelle M, HOAR, Kara M
Published in Cancer research (Chicago, Ill.) (01.12.2001)
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Published in Cancer research (Chicago, Ill.) (01.12.2001)
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Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by aurora A : A novel pharmacodynamic method for measuring aurora a activity
LEROY, Patrick J, HUNTER, John J, HOAR, Kara M, BURKE, Krissy E, SHINDE, Vaishali, RUAN, Jason, BOWMAN, Douglas, GALVIN, Katherine, ECSEDY, Jeffrey A
Published in Cancer research (Chicago, Ill.) (01.06.2007)
Published in Cancer research (Chicago, Ill.) (01.06.2007)
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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer
Langston, Steven P, Grossman, Stephen, England, Dylan, Afroze, Roushan, Bence, Neil, Bowman, Douglas, Bump, Nancy, Chau, Ryan, Chuang, Bei-Ching, Claiborne, Christopher, Cohen, Larry, Connolly, Kelly, Duffey, Matthew, Durvasula, Nitya, Freeze, Scott, Gallery, Melissa, Galvin, Katherine, Gaulin, Jeffrey, Gershman, Rachel, Greenspan, Paul, Grieves, Jessica, Guo, Jianping, Gulavita, Nanda, Hailu, Shumet, He, Xingyue, Hoar, Kara, Hu, Yongbo, Hu, Zhigen, Ito, Mitsuhiro, Kim, Mi-Sook, Lane, Scott Weston, Lok, David, Lublinsky, Anya, Mallender, William, McIntyre, Charles, Minissale, James, Mizutani, Hirotake, Mizutani, Miho, Molchinova, Nina, Ono, Koji, Patil, Ashok, Qian, Mark, Riceberg, Jessica, Shindi, Vaishali, Sintchak, Michael D, Song, Keli, Soucy, Teresa, Wang, Yana, Xu, He, Yang, Xiaofeng, Zawadzka, Agatha, Zhang, Ji, Pulukuri, Sai M
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Potent Histone Deacetylase Inhibitors Derived from 4‑(Aminomethyl)‑N‑hydroxybenzamide with High Selectivity for the HDAC6 Isoform
Blackburn, Christopher, Barrett, Cynthia, Chin, Janice, Garcia, Kris, Gigstad, Kenneth, Gould, Alexandra, Gutierrez, Juan, Harrison, Sean, Hoar, Kara, Lynch, Chrissie, Rowland, R. Scott, Tsu, Chris, Ringeling, John, Xu, He
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
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Abstract C82: Identification and preclinical characterization of inhibitors of the ubiquitin-activating enzymes UBA1 and UBA6
Bence, Neil, Fleming, Paul, Ciavarri, Jeff, Milhollen, Michael, Pulukuri, Sai, Hyer, Marc, Traore, Tary, Huck, Jessica, Tou, Derek, Sappal, Darshan, Hoar, Kara, Gavin, James, Yang, Yu, Brownell, James, Smith, Peter, Dick, Lawrence, Veiby, Petter, Manfredi, Mark, Claiborne, Christopher
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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