3-(4-fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT2A receptor antagonist
Rowley, M, Hallett, DJ, Goodacre, S, Moyes, C, Crawforth, J, Sparey, TJ, Patel, S, Marwood, R, Patel, S, Thomas, S, Hitzel, L, O'Connor, D, Szeto, N, Castro, JL, Hutson, PH, MacLeod, AM
Published in Journal of medicinal chemistry (10.05.2001)
Published in Journal of medicinal chemistry (10.05.2001)
Get full text
Journal Article
4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors
Churcher, Ian, Beher, Dirk, Best, Jonathan D., Castro, José L., Clarke, Earl E., Gentry, Amy, Harrison, Timothy, Hitzel, Laure, Kay, Euan, Kerrad, Sonia, Lewis, Huw D., Morentin-Gutierrez, Pablo, Mortishire-Smith, Russell, Oakley, Paul J., Reilly, Michael, Shaw, Duncan E., Shearman, Mark S., Teall, Martin R., Williams, Susie, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Get full text
Journal Article
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists
Rowley, Michael, Hallett, David J, Goodacre, Simon, Moyes, Christopher, Crawforth, James, Sparey, Timothy J, Patel, Smita, Marwood, Rose, Patel, Shil, Thomas, Steven, Hitzel, Laure, O'Connor, Desmond, Szeto, Nicola, Castro, Jose L, Hutson, Peter H, MacLeod, Angus M
Published in Journal of medicinal chemistry (10.05.2001)
Published in Journal of medicinal chemistry (10.05.2001)
Get full text
Journal Article
Synthesis and Conformational Dynamics of Tricyclic Pyridones Containing a Fused Seven-Membered Ring
Gibson, Karl R, Hitzel, Laure, Mortishire-Smith, Russell J, Gerhard, Ute, Jelley, Richard A, Reeve, Austin J, Rowley, Michael, Nadin, Alan, Owens, Andrew P
Published in Journal of organic chemistry (27.12.2002)
Published in Journal of organic chemistry (27.12.2002)
Get full text
Journal Article
Neighboring Group Participation of the Indole Nucleus: An Unusual DAST-Mediated Rearrangement Reaction
Hallett, David J, Gerhard, Ute, Goodacre, Simon C, Hitzel, Laure, Sparey, Timothy J, Thomas, Steven, Rowley, Michael, Ball, Richard G
Published in Journal of organic chemistry (11.08.2000)
Published in Journal of organic chemistry (11.08.2000)
Get full text
Journal Article
Determination of the in vitro metabolism of (+)- and (−)-epibatidine
Watt, Alan P, Hitzel, Laure, Morrison, Denise, Locker, Karen L
Published in Journal of Chromatography A (27.10.2000)
Published in Journal of Chromatography A (27.10.2000)
Get full text
Journal Article
Conference Proceeding
3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists
Russell, M G, Matassa, V G, Pengilley, R R, van Niel, M B, Sohal, B, Watt, A P, Hitzel, L, Beer, M S, Stanton, J A, Broughton, H B, Castro, J L
Published in Journal of medicinal chemistry (02.12.1999)
Published in Journal of medicinal chemistry (02.12.1999)
Get full text
Journal Article
CHIRAL SEPARATION OF 4,4-DISUBSTITUTED PIPERIDINYL SUBSTANCE P ANTAGONISTS
Watt, Alan P., Hitzel, Laure
Published in Journal of liquid chromatography & related technologies (19.09.2000)
Published in Journal of liquid chromatography & related technologies (19.09.2000)
Get full text
Journal Article
Use of chiral liquid chromatography–tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists
Watt, Alan P, Hitzel, Laure, Morrison, Denise, Locker, Karen L
Published in Journal of Chromatography A (27.10.2000)
Published in Journal of Chromatography A (27.10.2000)
Get full text
Journal Article
Conference Proceeding
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists
Rowley, M, Hallett, D J, Goodacre, S, Moyes, C, Crawforth, J, Sparey, T J, Patel, S, Marwood, R, Thomas, S, Hitzel, L, O'Connor, D, Szeto, N, Castro, J L, Hutson, P H, MacLeod, A M
Published in Journal of medicinal chemistry (10.05.2001)
Get full text
Published in Journal of medicinal chemistry (10.05.2001)
Journal Article
3-[3-(Piperidin-1-yl)propyl]indoles as Highly Selective h5-HT1D Receptor Agonists
Russell, Michael G. N, Matassa, Victor G, Pengilley, Roy R, van Niel, Monique B, Sohal, Bindi, Watt, Alan P, Hitzel, Laure, Beer, Margaret S, Stanton, Josephine A, Broughton, Howard B, Castro, José L
Published in Journal of medicinal chemistry (02.12.1999)
Published in Journal of medicinal chemistry (02.12.1999)
Get full text
Journal Article
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands
van Niel, M B, Beer, M S, Castro, J L, Cheng, S K, Evans, D C, Heald, A, Hitzel, L, Hunt, P, Mortishire-Smith, R, O'Connor, D, Watt, A P, MacLeod, A M
Published in Bioorganic & medicinal chemistry letters (15.11.1999)
Published in Bioorganic & medicinal chemistry letters (15.11.1999)
Get full text
Journal Article
Chiral separation of 4,4-disubstituted piperidinyl substance P antagonists
WATT, Alan P, HITZEL, Laure
Published in Journal of liquid chromatography & related technologies (01.09.2000)
Get full text
Published in Journal of liquid chromatography & related technologies (01.09.2000)
Journal Article
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT1A and 5-HT Re-uptake ligands
VAN NIEL, M. B, BEER, M. S, WATT, A. P, MACLEOD, A. M, CASTRO, J. L, CHENG, S. K. F, EVANS, D. C, HEALD, A, HITZEL, L, HUNT, P, MORTISHIRE-SMITH, R, O'CONNOR, D
Published in Bioorganic & medicinal chemistry letters (15.11.1999)
Published in Bioorganic & medicinal chemistry letters (15.11.1999)
Get full text
Journal Article
An Efficient Protocol for the Preparation of Primary Alcohols Bearing a β-Chiral Center via an Oxazolidinone Auxiliary Mediated Resolution, and Application to the Synthesis of 4,4-Disubstituted Piperidine Substance P Antagonists
Lewis, Richard T, Ladduwahetty, Tamara, Merchant, Kevin J, Keown, Linda E, Hitzel, Laure, Verrier, Hugh, Stevenson, Graeme I, MacLeod, Angus M
Published in Journal of organic chemistry (21.04.2000)
Published in Journal of organic chemistry (21.04.2000)
Get full text
Journal Article