The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
Harris, William J., Huang, Xu, Lynch, James T., Spencer, Gary J., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Miller, Crispin J., Ogilvie, Donald J., Somervaille, Tim C.P.
Published in Cancer cell (17.04.2012)
Published in Cancer cell (17.04.2012)
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Journal Article
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia
Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Published in Cell reports (Cambridge) (27.03.2018)
Published in Cell reports (Cambridge) (27.03.2018)
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Journal Article
ERK5 is a critical mediator of inflammation-driven cancer
Finegan, Katherine G, Perez-Madrigal, Diana, Hitchin, James R, Davies, Clare C, Jordan, Allan M, Tournier, Cathy
Published in Cancer research (Chicago, Ill.) (15.02.2015)
Published in Cancer research (Chicago, Ill.) (15.02.2015)
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Journal Article
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides
Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Journal Article
Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells
Atkin, Jane, Halova, Lenka, Ferguson, Jennifer, Hitchin, James R, Lichawska-Cieslar, Agata, Jordan, Allan M, Pines, Jonathon, Wellbrock, Claudia, Petersen, Janni
Published in Journal of cell science (15.03.2014)
Published in Journal of cell science (15.03.2014)
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Journal Article
Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II
Raoof, Ali, Depledge, Paul, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hopkins, Gemma V, Jordan, Allan M, Maguire, Laura A, McGonagle, Alison E, Mould, Daniel P, Rushbrooke, Mathew, Small, Helen F, Smith, Kate M, Thomson, Graeme J, Turlais, Fabrice, Waddell, Ian D, Waszkowycz, Bohdan, Watson, Amanda J, Ogilvie, Donald J
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Journal Article
NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24
Torres, Felix, Walser, Reto, Kaderli, Janina, Rossi, Emanuele, Bobby, Romel, Packer, Martin J, Sarda, Sunil, Walker, Graeme, Hitchin, James R, Milbradt, Alexander G, Orts, Julien
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib
James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J
Published in ACS chemical biology (18.11.2016)
Published in ACS chemical biology (18.11.2016)
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Journal Article
The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
Harris, William J., Huang, Xu, Lynch, James T., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Ogilvie, Donald J., Somervaille, Tim C.P.
Published in Cancer cell (12.06.2012)
Published in Cancer cell (12.06.2012)
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Journal Article
CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1
Lynch, James T., Cockerill, Mark J., Hitchin, James R., Wiseman, Daniel H., Somervaille, Tim C.P.
Published in Analytical biochemistry (01.11.2013)
Published in Analytical biochemistry (01.11.2013)
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Journal Article
Discovery of potent inhibitors of the lysophospholipase autotaxin
Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Journal Article
Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase
Hamilton, Niall M, Dawson, Martin, Fairweather, Emma E, Hamilton, Nicola S, Hitchin, James R, James, Dominic I, Jones, Stuart D, Jordan, Allan M, Lyons, Amanda J, Small, Helen F, Thomson, Graeme J, Waddell, Ian D, Ogilvie, Donald J
Published in Journal of medicinal chemistry (10.05.2012)
Published in Journal of medicinal chemistry (10.05.2012)
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Journal Article
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure
Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.
Published in Bioorganic & medicinal chemistry letters (15.02.2019)
Published in Bioorganic & medicinal chemistry letters (15.02.2019)
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Journal Article
Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments
Hitchin, James R., Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma E., Hutton, Colin, Jordan, Allan M., McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J., Waddell, Ian, Ogilvie, Donald J.
Published in MedChemComm (01.11.2013)
Published in MedChemComm (01.11.2013)
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Journal Article
Discovery of potent inhibitors of the lyso phospholipase autotaxin
Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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Journal Article
AhR 신호전달의 조절에 유용한 피리도피리미딘 유도체
MAJOR SARAH, HITCHIN JAMES R, GRAHAM MARK, TOMLINSON WENDY, STOCKS MICHAEL
Year of Publication 18.11.2022
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Year of Publication 18.11.2022
Patent
조절제로서의 테트라하이드로피리도피리미딘 유도체
KING UNDERWOOD JOHN, HITCHIN JAMES R, METE ANTONIO, GRAHAM MARK, THORNE PHILIP VELLACOTT
Year of Publication 04.05.2021
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Year of Publication 04.05.2021
Patent
PARG 24---6- 24-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG
MCGONAGLE ALISON E, JORDAN ALLAN, SMITH KATE MARY, HUTTON COLIN, HAMILTON NIALL M, WADDELL IAN, HITCHIN JAMES R, WASZKOWYCZ BOHDAN
Year of Publication 16.08.2017
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Year of Publication 16.08.2017
Patent
PARG PARG INHIBITORY COMPOUNDS
MCGONAGLE ALISON E, WADDELL IAN D, HAMILTON NIALL M, HITCHIN JAMES R, SMITH KATE M, HUTTON COLIN P, WASZKOWYCZ BOHDAN, JORDAN ALLAN M
Year of Publication 22.08.2017
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Year of Publication 22.08.2017
Patent