Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A, Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A, Pulgar Prieto, Katiuska D, Poojari, Chetan, Sharma, Vivek, Richter, Christian P, Kurre, Rainer, Hubbard, Stevan R, Garcia, K Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S, Piehler, Jacob
Published in Science (American Association for the Advancement of Science) (07.02.2020)
Published in Science (American Association for the Advancement of Science) (07.02.2020)
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The thrombopoietin receptor: revisiting the master regulator of platelet production
Hitchcock, Ian S., Hafer, Maximillian, Sangkhae, Veena, Tucker, Julie A.
Published in Platelets (Edinburgh) (18.08.2021)
Published in Platelets (Edinburgh) (18.08.2021)
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The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm
Sangkhae, Veena, Etheridge, S. Leah, Kaushansky, Kenneth, Hitchcock, Ian S.
Published in Blood (18.12.2014)
Published in Blood (18.12.2014)
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Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors
Cui, Lu, Moraga, Ignacio, Lerbs, Tristan, Van Neste, Camille, Wilmes, Stephan, Tsutsumi, Naotaka, Trotman-Grant, Aaron Claudius, Gakovic, Milica, Andrews, Sarah, Gotlib, Jason, Darmanis, Spyros, Enge, Martin, Quake, Stephen, Hitchcock, Ian S, Piehler, Jacob, Garcia, K Christopher, Wernig, Gerlinde
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2021)
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JAK2V₆₁₇F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms
Etheridge, S. Leah, Roh, Michelle E., Cosgrove, Megan E., Sangkhae, Veena, Fox, Norma E., Chen, Junmei, López, José A., Kaushansky, Kenneth, Hitchcock, Ian S.
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2014)
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Journal Article
A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis
Etheridge, S. Leah, Cosgrove, Megan E., Sangkhae, Veena, Corbo, Lana M., Roh, Michelle E., Seeliger, Markus A., Chan, Edward L., Hitchcock, Ian S.
Published in Blood (13.02.2014)
Published in Blood (13.02.2014)
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Ubiquitination and degradation of the thrombopoietin receptor c-Mpl
Saur, Sebastian J., Sangkhae, Veena, Geddis, Amy E., Kaushansky, Kenneth, Hitchcock, Ian S.
Published in Blood (11.02.2010)
Published in Blood (11.02.2010)
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Quantitative Optical Diffraction Tomography Imaging of Mouse Platelets
Stanly, Tess A, Suman, Rakesh, Rani, Gulab Fatima, O'Toole, Peter J, Kaye, Paul M, Hitchcock, Ian S
Published in Frontiers in physiology (16.09.2020)
Published in Frontiers in physiology (16.09.2020)
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Journal Article
CD4 + T Cells Alter the Stromal Microenvironment and Repress Medullary Erythropoiesis in Murine Visceral Leishmaniasis
Preham, Olivier, Pinho, Flaviane A, Pinto, Ana Isabel, Rani, Gulab Fatima, Brown, Najmeeyah, Hitchcock, Ian S, Goto, Hiro, Kaye, Paul M
Published in Frontiers in immunology (18.12.2018)
Published in Frontiers in immunology (18.12.2018)
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Journal Article
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage–specific FAK knockout
Hitchcock, Ian S., Fox, Norma E., Prévost, Nicolas, Sear, Katherine, Shattil, Sanford J., Kaushansky, Kenneth
Published in Blood (15.01.2008)
Published in Blood (15.01.2008)
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Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets
Psaila, Bethan, Wang, Guanlin, Rodriguez-Meira, Alba, Li, Rong, Heuston, Elisabeth F, Murphy, Lauren, Yee, Daniel, Hitchcock, Ian S, Sousos, Nikolaos, O'Sullivan, Jennifer, Anderson, Stacie, Senis, Yotis A, Weinberg, Olga K, Calicchio, Monica L, Iskander, Deena, Royston, Daniel, Milojkovic, Dragana, Roberts, Irene, Bodine, David M, Thongjuea, Supat, Mead, Adam J
Published in Molecular cell (07.05.2020)
Published in Molecular cell (07.05.2020)
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Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma
Lang, Shona H., Hyde, Catherine, Reid, Ian N., Hitchcock, Ian S., Hart, Claire A., Gordon Bryden, A. A., Villette, Jean-Marie, Stower, Michael J., Maitland, Norman J.
Published in The Prostate (01.09.2002)
Published in The Prostate (01.09.2002)
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Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis
Tsutsumi, Naotaka, Masoumi, Zahra, James, Sophie C., Tucker, Julie A., Winkelmann, Hauke, Grey, William, Picton, Lora K., Moss, Lucie, Wilson, Steven C., Caveney, Nathanael A., Jude, Kevin M., Gati, Cornelius, Piehler, Jacob, Hitchcock, Ian S., Garcia, K. Christopher
Published in Cell (14.09.2023)
Published in Cell (14.09.2023)
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Journal Article
Essential components for a glutamatergic synapse between Merkel cell and nerve terminal in rats
Hitchcock, Ian S., Genever, Paul G., Cahusac, Peter M.B.
Published in Neuroscience letters (27.05.2004)
Published in Neuroscience letters (27.05.2004)
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Journal Article
Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN
Reis, Edimara S., Buonpane, Rebecca, Celik, Hamza, Marty, Caroline, Lei, Angela, Jobe, Fatoumata, Rupar, Mark, Zhang, Yue, DiMatteo, Darlise, Awdew, Rahel, Ferreira, Bianca L., Leffet, Lynn, Lu, Lu, Rosa, Elodie, Evrard, Maxime, Trivedi, Gaurang, Wass, Brittney, Horsey, April, He, Xin, Covington, Maryanne, Volgina, Alla, Pasquier, Florence, Legros, Laurence, Fouquet, Guillemette, Vainchenker, William, Yang, Yan-ou, Barker, Breann, Zhou, Jing, Stewart, Shaun, Hitchcock, Ian S., Dhanak, Dashyant, Macarron, Ricardo, Plo, Isabelle, Nastri, Horacio, Mayes, Patrick A.
Published in Blood (10.09.2024)
Published in Blood (10.09.2024)
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