Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model
Nakatsuka, Daiki, Izumi, Takaya, Tsukamoto, Tasuku, Oyama, Miki, Nishitomi, Kohei, Deguchi, Yuichi, Niidome, Kazuki, Yamakawa, Hidekuni, Ito, Hisanori, Ogawa, Koichi
Published in Frontiers in molecular neuroscience (24.11.2021)
Published in Frontiers in molecular neuroscience (24.11.2021)
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Journal Article
Early Postnatal Treatment with Valproate Induces Gad1 Promoter Remodeling in the Brain and Reduces Apnea Episodes in Mecp2 -Null Mice
Ishiyama, Misa, Tamura, Satoko, Ito, Hisanori, Takei, Hiroki, Hoshi, Manami, Asano, Masatake, Itoh, Masayuki, Shirakawa, Tetsuo
Published in International journal of molecular sciences (18.10.2019)
Published in International journal of molecular sciences (18.10.2019)
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Journal Article
Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts
Kifune, Takashi, Ito, Hisanori, Ishiyama, Misa, Iwasa, Satoko, Takei, Hiroki, Hasegawa, Tomokazu, Asano, Masatake, Shirakawa, Tetsuo
Published in Journal of Oral Science (2018)
Published in Journal of Oral Science (2018)
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Journal Article
Effect of hypoxia on the expression of CCAAT/enhancer-binding protein β and receptor activator of nuclear factor kappa-B ligand in periodontal ligament cells
Ito, Hisanori, Kifune, Takashi, Ishiyama, Misa, Iwasa, Satoko, Takei, Hiroki, Hasegawa, Tomokazu, Asano, Masatake, Shirakawa, Tetsuo
Published in Journal of Oral Science (2018)
Published in Journal of Oral Science (2018)
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Journal Article
Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models
Minami, Kazuhisa, Hasegawa, Minoru, Ito, Hisanori, Nakamura, Atsushi, Tomii, Takako, Matsumoto, Mitsunobu, Orita, Satoshi, Matsushima, Syuichi, Miyoshi, Takako, Masuno, Koichi, Torii, Mikinori, Koike, Katsumi, Shimada, Shinji, Kanemasa, Toshiyuki, Kihara, Tsuyoshi, Narita, Minoru, Suzuki, Tsutomu, Kato, Akira
Published in Journal of Pharmacological Sciences (2009)
Published in Journal of Pharmacological Sciences (2009)
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Journal Article
Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1
Ito, Hisanori, Nakajima, Aki, Nomoto, Hiroshi, Furukawa, Shoei
Published in Journal of neuroscience research (01.03.2003)
Published in Journal of neuroscience research (01.03.2003)
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Journal Article
Distinct relations among plasma concentrations required for different pharmacological effects in oxycodone, morphine, and fentanyl
Nakamura, Atsushi, Hasegawa, Minoru, Ito, Hisanori, Minami, Kazuhisa, Koike, Katsumi, Habu-Tomita, Naoko, Nanba, Kenkichi, Hamaguchi, Kayo, Noshi, Eriko, Hashimoto, Hiroshi, Nishino, Ikuko, Okabayashi, Yoshito, Koyabu, Kiyotaka, Kihara, Tsuyoshi, Iwamoto, Yuka, Inoue, Yuji, Narita, Minoru, Suzuki, Tsutomu, Kato, Akira
Published in Journal of pain & palliative care pharmacotherapy (11.11.2011)
Published in Journal of pain & palliative care pharmacotherapy (11.11.2011)
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Journal Article
Oxycodone-Induced Analgesic Effects in a Bone Cancer Pain Model in Mice
Kato, Akira, Minami, Kazuhisa, Ito, Hisanori, Tomii, Takako, Matsumoto, Mitsunobu, Orita, Satoshi, Kihara, Tsuyoshi, Narita, Minoru, Suzuki, Tsutomu
Published in Oncology (01.01.2008)
Published in Oncology (01.01.2008)
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Journal Article
Conference Proceeding
4-Methylcatechol Increases Brain-Derived Neurotrophic Factor Content and mRNA Expression in Cultured Brain Cells and in Rat Brain In Vivo
Nitta, A, Ito, M, Fukumitsu, H, Ohmiya, M, Ito, H, Sometani, A, Nomoto, H, Furukawa, Y, Furukawa, S
Published in The Journal of pharmacology and experimental therapeutics (01.12.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1999)
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Balancing potency and basicity by incorporating fluoropyridine moieties: Discovery of a 1-amino-3,4-dihydro-2,6-naphthyridine BACE1 inhibitor that affords robust and sustained central Aβ reduction
Nakahara, Kenji, Mitsuoka, Yasunori, Kasuya, Satoshi, Yamamoto, Takahiko, Yamamoto, Shiho, Ito, Hisanori, Kido, Yasuto, Kusakabe, Ken-ichi
Published in European journal of medicinal chemistry (15.04.2021)
Published in European journal of medicinal chemistry (15.04.2021)
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Journal Article
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β‑Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
Koriyama, Yuji, Hori, Akihiro, Ito, Hisanori, Yonezawa, Shuji, Baba, Yoshiyasu, Tanimoto, Norihiko, Ueno, Tatsuhiko, Yamamoto, Shiho, Yamamoto, Takahiko, Asada, Naoya, Morimoto, Kenji, Einaru, Shunsuke, Sakai, Katsunori, Kanazu, Takushi, Matsuda, Akihiro, Yamaguchi, Yoshitaka, Oguma, Takuya, Timmers, Maarten, Tritsmans, Luc, Kusakabe, Ken-ichi, Kato, Akira, Sakaguchi, Gaku
Published in Journal of medicinal chemistry (25.02.2021)
Published in Journal of medicinal chemistry (25.02.2021)
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Journal Article
Structure-Based Design of Selective β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2
Fujimoto, Kazuki, Matsuoka, Eriko, Asada, Naoya, Tadano, Genta, Yamamoto, Takahiko, Nakahara, Kenji, Fuchino, Kouki, Ito, Hisanori, Kanegawa, Naoki, Moechars, Diederik, Gijsen, Harrie J. M, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
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O2G4-1 Studies on drug dependence (Rept. 429)：Characterization of tolerance to anti- hyperalgesic effects induced by chronic treatment with morphine, oxycodone and fentanyl under a neuropathic pain-like state in mice
Atsushi Nakamura, Minoru Narita, Hisanori Ito, Ayumi Ozeki, Daiki Okutsu, Yuki Takigawa, Masami Suzuki, Tsuyoshi Kihara, Akira Kato, Tsutomu Suzuki
Published in Journal of Pharmacological Sciences (2008)
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Published in Journal of Pharmacological Sciences (2008)
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P2-049 Neuroprotective effects of 2-(2-hydroxylphenyl)benzoxazol derivatives via induction of brain-derived neurotrophic factor synthesis
Hisanori Ito, Gaku Sakaguchi, Toshinaga Tsuji, Tsuyoshi Kihara, Shoei Furukawa, Norihiko Tanimoto, Akira Kato
Published in Journal of Pharmacological Sciences (2007)
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Published in Journal of Pharmacological Sciences (2007)
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Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β‑Secretase (BACE1) Inhibitors over BACE2
Fujimoto, Kazuki, Yoshida, Shuhei, Tadano, Genta, Asada, Naoya, Fuchino, Kouki, Suzuki, Shinji, Matsuoka, Eriko, Yamamoto, Takahiko, Yamamoto, Shiho, Ando, Shigeru, Kanegawa, Naoki, Tonomura, Yutaka, Ito, Hisanori, Moechars, Diederik, Rombouts, Frederik J. R, Gijsen, Harrie J. M, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Discovery of Potent and Centrally Active 6‑Substituted 5‑Fluoro-1,3-dihydro-oxazine β‑Secretase (BACE1) Inhibitors via Active Conformation Stabilization
Nakahara, Kenji, Fuchino, Kouki, Komano, Kazuo, Asada, Naoya, Tadano, Genta, Hasegawa, Tsuyoshi, Yamamoto, Takahiko, Sako, Yusuke, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Ohnishi, Shuichi, Kido, Yasuto, Fukushima, Tamio, Dhuyvetter, Deborah, Borghys, Herman, Gijsen, Harrie J. M, Yamano, Yoshinori, Iso, Yasuyoshi, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Journal Article
Rational Design of Novel 1,3-Oxazine Based β‑Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P‑gp Efflux Leading to Robust Aβ Reduction in the Brain
Fuchino, Kouki, Mitsuoka, Yasunori, Masui, Moriyasu, Kurose, Noriyuki, Yoshida, Shuhei, Komano, Kazuo, Yamamoto, Takahiko, Ogawa, Masayoshi, Unemura, Chie, Hosono, Motoko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Ohnishi, Shuichi, Kido, Yasuto, Fukushima, Tamio, Miyajima, Hirofumi, Hiroyama, Shuichi, Koyabu, Kiyotaka, Dhuyvetter, Deborah, Borghys, Herman, Gijsen, Harrie J. M, Yamano, Yoshinori, Iso, Yasuyoshi, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Discovery of Extremely Selective Fused Pyridine-Derived β‑Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions
Ueno, Tatsuhiko, Matsuoka, Eriko, Asada, Naoya, Yamamoto, Shiho, Kanegawa, Naoki, Ito, Mana, Ito, Hisanori, Moechars, Diederik, Rombouts, Frederik J. R, Gijsen, Harrie J. M, Kusakabe, Ken-ichi
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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