Search Results - "Hisamichi, Hiroyuki" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives

by Hisamichi, Hiroyuki, Naito, Ryo, Toyoshima, Akira, Kawano, Noriyuki, Ichikawa, Atsushi, Orita, Akiko, Orita, Masaya, Hamada, Noritaka, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (15.08.2005)

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Journal Article

YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors

by Amino, Nobuaki, Ideyama, Yukitaka, Yamano, Mayumi, Kuromitsu, Sadao, Tajinda, Katsuinori, Samizu, Kiyohiro, Hisamichi, Hiroyuki, Matsuhisa, Akira, Shirasuna, Kenna, Kudoh, Masafumi, Shibasaki, Masayuki
Published in Clinical cancer research (01.03.2006)

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Journal Article

Synthetic Studies on Selective Type 4 Phosphodiesterase (PDE 4) Inhibitors. 1. Structure–Activity Relationships and Pharmacological Evaluation of 1,8-Naphthyridin-2(1H)-one Derivatives

Synthetic Studies on Selective Type 4 Phosphodiesterase (PDE 4) Inhibitors. 1. Structure–Activity Relationships and Pharmacological Evaluation of 1,8-Naphthyridin-2(1H)-one Derivatives

by Takayama, Kazuhisa, Iwata, Masahiro, Hisamichi, Hiroyuki, Okamoto, Yoshinori, Aoki, Motonori, Niwa, Akira
Published in Chemical & pharmaceutical bulletin (01.08.2002)

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Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

by Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Terasaka, Tadashi, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Kikuchi, Aya, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.04.2022)

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Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

by Kuriwaki, Ikumi, Kameda, Minoru, Hisamichi, Hiroyuki, Kikuchi, Shigetoshi, Iikubo, Kazuhiko, Kawamoto, Yuichiro, Moritomo, Hiroyuki, Kondoh, Yutaka, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Suzuki, Tomoyuki, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (15.05.2020)

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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

by Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Kondoh, Yutaka, Terasaka, Tadashi, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Nakazawa, Taisuke, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.03.2021)

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Structure-activity Relationships of Cephalosporins Having a (Dimethylisoxazolidinio)vinyl Moiety at Their 3-Position

Structure-activity Relationships of Cephalosporins Having a (Dimethylisoxazolidinio)vinyl Moiety at Their 3-Position

by HARAI, RYUICHIRO, SAKAMOTO, KENICHIRO, HISAMICHI, HIROYUKI, NAGANO, NORIAKI
Published in Journal of antibiotics (01.11.1996)

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Journal Article

Synthesis and Biological Activity of New Cephem Compounds with a 3-(2-Butenyl)- and a 3-(1,3-Butadienyl)groupat Their 3-Position

Synthesis and Biological Activity of New Cephem Compounds with a 3-(2-Butenyl)- and a 3-(1,3-Butadienyl)groupat Their 3-Position

by HARA, RYUICHIRO, ITAHANA, HIROTSUNE, HISAMICHI, HIROYUKI, FUKUOKA, SUMIE, NAGANO, NORIAKI
Published in Journal of antibiotics (1996)

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Cycloaddition reactions of a 3-(1,3-butadienyl)cephalosporin and antibacterial activity of new cephem derivatives

Cycloaddition reactions of a 3-(1,3-butadienyl)cephalosporin and antibacterial activity of new cephem derivatives

by Hara, R, Itahana, H, Sakamoto, K, Hisamichi, H, Nagano, N
Published in Journal of antibiotics (01.11.1996)

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Journal Article

1- TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

1- TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

by TAKUWA TOMOFUMI, ISHIHARA TSUKASA, MAENO KYOICHI, ISHIKAWA NORIKO, SHIMIZU TAKAFUMI, SEKI NORIO, SHIMADA ITSURO, HISAMICHI HIROYUKI
Year of Publication 06.12.2016

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Patent

Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors

Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors

by Katayama, Naoko, Orita, Masaya, Yamaguchi, Tomohiko, Hisamichi, Hiroyuki, Kuromitsu, Sadao, Kurihara, Hiroyuki, Sakashita, Hitoshi, Matsumoto, Yuzo, Fujita, Shigeo, Niimi, Tatsuya
Published in Proteins, structure, function, and bioinformatics (01.12.2008)

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Journal Article

STUDIES ON β-LACTAM ANTIBIOTICS: IV. AN IMPROVED SYNTHESIS OF 3-(ISOTHIAZOLYLTHIOMETHYL)CEPHALOSPORINS AND ITS APPLICATION TO NEW DERIVATIVES

STUDIES ON β-LACTAM ANTIBIOTICS: IV. AN IMPROVED SYNTHESIS OF 3-(ISOTHIAZOLYLTHIOMETHYL)CEPHALOSPORINS AND ITS APPLICATION TO NEW DERIVATIVES

by HARA, RYUICHIRO, NAKAI, EI-ICHI, HISAMICHI, HIROYUKI, NAGANO, NORIAKI
Published in Journal of antibiotics (1994)

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Journal Article

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by ISHIHARA TSUKASA, KURIWAKI IKUMI, TAKESHITA NOBUAKI, TAKEZAWA RYUICHI, IKEGAI KAZUHIRO, HISAMICHI HIROYUKI
Year of Publication 12.02.2016

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Patent

TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

by TAKUWA TOMOFUMI, ISHIHARA TSUKASA, MAENO KYOICHI, ISHIKAWA NORIKO, SHIMIZU TAKAFUMI, SEKI NORIO, SHIMADA ITSURO, HISAMICHI HIROYUKI
Year of Publication 05.08.2015

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Patent

BENZOTHIOPHENE COMPOUND

BENZOTHIOPHENE COMPOUND

by ISHIHARA, TSUKASA, KURIWAKI, IKUMI, HISAMICHI, HIROYUKI, TAKEZAWA, RYUICHI, TAKESHITA, NOBUAKI, IKEGAI, KAZUHIRO
Year of Publication 11.12.2014

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Patent

NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

by ASAUMI MAKOTO, OKADA HARUKI, KAWAMOTO YUICHIRO, KAMEDA MINORU, KURIWAKI IKUMI, MIYASAKA KOZO, MORITOMO HIROYUKI, SUZUKI ATSUSHI, FUTAMI TAKASHI, TSUNOYAMA KAZUHISA, TOKUZAKI KAZUO, SUZUKI TOMOYUKI, TOMIYAMA HIROSHI, NODA ATSUSHI, IIKUBO KAZUHIKO, HISAMICHI HIROYUKI, IWAI YOSHINORI
Year of Publication 06.11.2014

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Patent

YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine klinase inhibitor, has highly potent antitumor activity against established tumors

YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine klinase inhibitor, has highly potent antitumor activity against established tumors

by AMINO, Nobuaki, IDEYAMA, Yukitaka, SHIBASAKI, Masayuki, YAMANO, Mayumi, KUROMITSU, Sadao, TAJINDA, Katsuinori, SAMIZU, Kiyohiro, HISAMICHI, Hiroyuki, MATSUHISA, Akira, SHIRASUNA, Kenna, KUDOH, Masafumi
Published in Clinical cancer research (2006)

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Journal Article

NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

by OKADA, HARUKI, ASAUMI, MAKOTO, TOMIYAMA, HIROSHI, KURIWAKI, IKUMI, KAMEDA, MINORU, NODA, ATSUSHI, MIYASAKA, KOZO, IWAI, YOSHINORI, TOKUZAKI, KAZUO, HISAMICHI, HIROYUKI, KAWAMOTO, YUICHIRO, SUZUKI, ATSUSHI, TSUNOYAMA, KAZUHISA, IIKUBO, KAZUHIKO, FUTAMI, TAKASHI, SUZUKI, TOMOYUKI, MORITOMO, HIROYUKI
Year of Publication 06.09.2013

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Patent

TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF

by ISHIHARA, TSUKASA, TAKUWA, TOMOFUMI, SHIMIZU, TAKAFUMI, ISHIKAWA, NORIKO, HISAMICHI, HIROYUKI, SHIMADA, ITSURO, MAENO, KYOICHI, SEKI, NORIO
Year of Publication 04.12.2008

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Patent

Corrigendum to “Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives” [Bioorg. Med. Chem. 13 (2005) 4936–4951]

Corrigendum to “Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives” [Bioorg. Med. Chem. 13 (2005) 4936–4951]

by Hisamichi, Hiroyuki, Naito, Ryo, Toyoshima, Akira, Kawano, Noriyuki, Ichikawa, Atsushi, Orita, Akiko, Orita, Masaya, Hamada, Noritaka, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi
Published in Bioorganic & medicinal chemistry (01.11.2005)

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