Data silos are undermining drug development and failing rare disease patients
Denton, Nathan, Molloy, Monique, Charleston, Samantha, Lipset, Craig, Hirsch, Jonathan, Mulberg, Andrew E, Howard, Paul, Marsh, Eric D
Published in Orphanet journal of rare diseases (07.04.2021)
Published in Orphanet journal of rare diseases (07.04.2021)
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Journal Article
Rapid real‐world data analysis of patients with cancer, with and without COVID‐19, across distinct health systems
Hwang, Clara, Izano, Monika A., Thompson, Michael A., Gadgeel, Shirish M., Weese, James L., Mikkelsen, Tom, Schrag, Andrew, Teka, Mahder, Walters, Sheetal, Wolf, Frank M., Hirsch, Jonathan, Rivera, Donna R., Kluetz, Paul G., Singh, Harpreet, Brown, Thomas D.
Published in Cancer Reports (01.10.2021)
Published in Cancer Reports (01.10.2021)
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Journal Article
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Albugranin, a recombinant human granulocyte colony stimulating factor (G-CSF) genetically fused to recombinant human albumin induces prolonged myelopoietic effects in mice and monkeys
HALPERN, Wendy, RICCOBENE, Todd A, GRZEGORZEWSKI, Krzysztof J, AGOSTINI, Heidi, BAKER, Kevin, STOLOW, David, GU, Mi-Li, HIRSCH, Jonathan, MAHONEY, Angela, CARRELL, Jeffrey, BOYD, Ernest
Published in Pharmaceutical research (01.11.2002)
Published in Pharmaceutical research (01.11.2002)
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Journal Article
Clinical Evaluation of a Titanium, Headless Variable-Pitched Tapered Cannulated Compression Screw for Repair of Frontal Plane Slab Fractures of the Third Carpal Bone in Thoroughbred Racehorses
HIRSCH, JONATHAN E, GALUPPO, LARRY D, GRAHAM, LINDSAY E, SIMPSON, EDWIN L, FERRARO, GREGORY L
Published in Veterinary surgery (01.02.2007)
Published in Veterinary surgery (01.02.2007)
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Journal Article
Molecular alterations with hyperprogression in lung cancer patients treated with immune checkpoint inhibitors in a large health system
Tadesse, Eyob ale, Heslin, Kayla, Hendawi, Mohamed, Hirsch, Jonathan, Idyro, Christopher, Thompson, Michael A.
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Overall survival in high and very high PD-L1 expressing patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors in a real-world data setting
Zhang, Chenan, Sweetnam, Connor, Wolf, Frank, Walters, Sheetal, Hirsch, Jonathan, Brown, Thomas D.
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Deriving real-world oral antineoplastic treatment endpoints: A comparison of automated data extraction versus manual chart abstraction
Chen, James Lin, Shadra, Chhaya, Cho-Phan, Cheryl D., Ghosh, Aradhana, Hirsch, Jonathan
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
Abstract 1676: A hybrid ontology and graph system enabling precision oncology applications through real-time incorporation of omics biomarkers into a scalable real-world data platform
Shima, James E., Chen, James L., Glick, Matthew J., Warrier, Ryan A., Abruzzese, Eric C., Mankowski, Walter C., Hirsch, Jonathan
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract CT086: Pneumonitis incidence in patients with non-small cell lung cancer treated with immunotherapy or chemotherapy in clinical trials and real-world data
Liu, Qi, Zhang, Chenan, Gong, Yutao, Zhu, Hao, Chang, Elaine, Cho-Phan, Cheryl, Hirsch, Jonathan, Thompson, Michael A., Blumenthal, Gideon, Huang, Shiew Mei, Brown, Thomas D.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Design and implementation of an informatics infrastructure for actionable precision oncology
Hirsch, Jonathan, Ford, James M., Nadauld, Lincoln, Hsu, Andro
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
The role of real-world evidence in clinical care: A survey of oncology leaders
Stahl, Melissa, Winzeler, Alissa M, Zaman, Ali, Shelby, Nicole, Chen, James Lin, Clutz, Bryan, Ghosh, Aradhana, Hirsch, Jonathan
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Abstract S10-02: Using real-world data (RWD) from an integrated platform for rapid analysis of patients with cancer with and without COVID-19 across distinct health systems
Gadgeel, Shirish M., Thompson, Michael A., Izano, Monika A., Hwang, Clara, Mikkelsen, Tom, Weese, James L., Wolf, Frank M., Schrag, Andrew, Walters, Sheetal, Singh, Harpreet, Hirsch, Jonathan, Brown, Thomas D., Kluetz, Paul G.
Published in Clinical cancer research (15.09.2020)
Published in Clinical cancer research (15.09.2020)
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Journal Article
Outcomes in patients with advanced non-small cell lung cancer (aNSCLC) and high PD-L1 expression treated with immune checkpoint inhibitor monotherapy: An FDA-pooled analysis
Shah, Sujay Yogesh, Vallejo, Jonathon Joseph, Gong, Yutao, Brown, Thomas D., Zhang, Chenan, Hirsch, Jonathan, Tang, Shenghui, Blumenthal, Gideon Michael, Singh, Harpreet, Kluetz, Paul Gustav, Theoret, Marc Robert, Beaver, Julia A., Pazdur, Richard
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
European Registry on Helicobacter pylori management (Hp-EuReg): First-line Therapy in Israel
Boltin, Doron, Beniashvili, Zaza, Lahat, Adi, Hirsch, Jonathan, Nyssen, Olga P, Mégraud, Francis, O'Morain, Colm, Gisbert, Javier P, Niv, Yaron
Published in The Israel Medical Association journal (01.01.2021)
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Published in The Israel Medical Association journal (01.01.2021)
Journal Article
COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patients
Stewart, Mark, Rodriguez-Watson, Carla, Albayrak, Adem, Asubonteng, Julius, Belli, Andrew, Brown, Thomas, Cho, Kelly, Das, Ritankar, Eldridge, Elizabeth, Gatto, Nicolle, Gelman, Alice, Gerlovin, Hanna, Goldberg, Stuart L, Hansen, Eric, Hirsch, Jonathan, Ho, Yuk-Lam, Ip, Andrew, Izano, Monika, Jones, Jason, Justice, Amy C, Klesh, Reyna, Kuranz, Seth, Lam, Carson, Mao, Qingqing, Mataraso, Samson, Mera, Robertino, Posner, Daniel C, Rassen, Jeremy A, Siefkas, Anna, Schrag, Andrew, Tourassi, Georgia, Weckstein, Andrew, Wolf, Frank, Bhat, Amar, Winckler, Susan, Sigal, Ellen V, Allen, Jeff
Published in PloS one (17.03.2021)
Published in PloS one (17.03.2021)
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Journal Article
Reportable actionability versus pragmatic actionability: Implementing precision medicine at three large health systems
Thompson, Michael A., Zaman, Ali, Winzeler, Alissa M, Kern, Jonathan, Ghosh, Aradhana, Hirsch, Jonathan, Godden, Jennifer, Weese, James Leighton, Singh, Maharaj, Eisenberg, Burton Larry, Demeure, Michael J., Haque, Nadia Z, Hoover, Spencer C., Kalkanis, Steven N.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Gender-based effect of statins on functional decline in amyotrophic lateral sclerosis
Nefussy, Beatrice, Hirsch, Jonathan, Cudkowicz, Merit E, Drory, Vivian E
Published in Journal of the neurological sciences (15.01.2011)
Published in Journal of the neurological sciences (15.01.2011)
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Journal Article
Successful automated normalization of cancer outcomes for half a million patients across four disparate health systems
Tittel, Paul D., Zaman, Ali, Shima, James E., Leal, David, Chen, James Lin, Ghosh, Aradhana, Hirsch, Jonathan, Trent, Jonathan C., Gordon, Bat-Ami, Cotta, Jared, Thompson, Michael A., Godden, Jennifer, Ruggeri, Antony, Weese, James Leighton, Haque, Nadia Z, Hoover, Spencer C., Kalkanis, Steven N.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Journal Article
Harnessing big data for precision medicine: A panel of experts elucidates the data challenges and proposes key strategic decisions points
Barash, Carol Isaacson, Elliston, Keith O., Andrew Faucett, W., Hirsch, Jonathan, Naik, Gauri, Rathjen, Alice, Wood, Grant
Published in Applied & translational genomics (01.03.2015)
Published in Applied & translational genomics (01.03.2015)
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Journal Article