Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method
Oyama, Takuji, Kamata, Shotaro, Ishii, Isao, Miyachi, Hiroyuki
Published in Biological & pharmaceutical bulletin (01.09.2021)
Published in Biological & pharmaceutical bulletin (01.09.2021)
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Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice
Haga, Hidaka, Yamada, Ryo, Izumi, Hisanao, Shinoda, Yasuharu, Kawahata, Ichiro, Miyachi, Hiroyuki, Fukunaga, Kohji
Published in Pharmacology, biochemistry and behavior (01.04.2020)
Published in Pharmacology, biochemistry and behavior (01.04.2020)
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Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists
Miyachi, Hiroyuki, Yuzuriha, Tomohiro, Tabata, Ryotaro, Fukuda, Syohei, Nunomura, Kazuto, Lin, Bangzhong, Kobayashi, Tadayuki, Ishimoto, Kenji, Doi, Takefumi, Tachibana, Keisuke
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives
Yoshida, Takuya, Oki, Hiroya, Doi, Michihiro, Fukuda, Syohei, Yuzuriha, Tomohiro, Tabata, Ryotaro, Ishimoto, Kenji, Kawahara, Kazuki, Ohkubo, Tadayasu, Miyachi, Hiroyuki, Doi, Takefumi, Tachibana, Keisuke
Published in Scientific reports (06.05.2020)
Published in Scientific reports (06.05.2020)
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Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization
Hayashi, Keiichiro, Michiue, Hiroyuki, Yamada, Hiroshi, Takata, Katsuyoshi, Nakayama, Hiroki, Wei, Fan-Yan, Fujimura, Atsushi, Tazawa, Hiroshi, Asai, Akira, Ogo, Naohisa, Miyachi, Hiroyuki, Nishiki, Tei-ichi, Tomizawa, Kazuhito, Takei, Kohji, Matsui, Hideki
Published in Scientific reports (18.03.2016)
Published in Scientific reports (18.03.2016)
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Structure, solubility, and permeability relationships in a diverse middle molecule library
Miyachi, Hiroyuki, Kanamitsu, Kayoko, Ishii, Mayumi, Watanabe, Eri, Katsuyama, Akira, Otsuguro, Satoko, Yakushiji, Fumika, Watanabe, Mizuki, Matsui, Kouhei, Sato, Yukina, Shuto, Satoshi, Tadokoro, Takashi, Kita, Shunsuke, Matsumaru, Takanori, Matsuda, Akira, Hirose, Tomoyasu, Iwatsuki, Masato, Shigeta, Yasuteru, Nagano, Tetsuo, Kojima, Hirotatsu, Ichikawa, Satoshi, Sunazuka, Toshiaki, Maenaka, Katsumi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
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Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands
Asano, Lisa, Ito, Ichiaki, Kuwabara, Naoyuki, Waku, Tsuyoshi, Yanagisawa, Junn, Miyachi, Hiroyuki, Shimizu, Toshiyuki
Published in FEBS letters (02.04.2013)
Published in FEBS letters (02.04.2013)
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1‐Fluoro‐2,4‐dinitrobenzene and its derivatives act as secretagogues on rodent mast cells
Manabe, Yohei, Yoshimura, Marie, Sakamaki, Kazuma, Inoue, Asuka, Kakinoki, Aya, Hokari, Satoshi, Sakanaka, Mariko, Aoki, Junken, Miyachi, Hiroyuki, Furuta, Kazuyuki, Tanaka, Satoshi
Published in European journal of immunology (01.01.2017)
Published in European journal of immunology (01.01.2017)
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γ-Mangostin from Garcinia Mangostana Pericarps as a Dual Agonist That Activates Both PPARα and PPARδ
MATSUURA, Nobuyasu, GAMO, Kanae, MIYACHI, Hiroyuki, IINUMA, Munekazu, KAWADA, Teruo, TAKAHASHI, Nobuyuki, AKAO, Yukihiro, TOSA, Hideki
Published in Bioscience, biotechnology, and biochemistry (2013)
Published in Bioscience, biotechnology, and biochemistry (2013)
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Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors
Kumazawa, Miyuki, Tejima, Manabu, Fukuda, Miwa, Takeda, Shota, Suzuki, Kenji, Mizumoto, Yukiko, Sato, Kakeru, Waki, Minoru, Miyachi, Hiroyuki, Asai, Akira, Takikawa, Osamu, Hashimoto, Tomoko, Ohno, Osamu, Matsuno, Kenji
Published in ACS medicinal chemistry letters (11.02.2021)
Published in ACS medicinal chemistry letters (11.02.2021)
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Structure–anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives
Sawada, Hiromi, Onoda, Kenji, Morita, Daichi, Ishitsubo, Erika, Matsuno, Kenji, Tokiwa, Hiroaki, Kuroda, Teruo, Miyachi, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
Oyama, Takuji, Toyota, Kenji, Waku, Tsuyoshi, Hirakawa, Yuko, Nagasawa, Naoko, Kasuga, Jun-ichi, Hashimoto, Yuichi, Miyachi, Hiroyuki, Morikawa, Kosuke
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2009)
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2009)
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Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication
Ban, Shintaro, Ueda, Youki, Ohashi, Masao, Matsuno, Kenji, Ikeda, Masanori, Kato, Nobuyuki, Miyachi, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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