Comprehensive exploration of chemical space using trisubstituted carboranes
Asawa, Yasunobu, Hatsuzawa, Saki, Yoshimori, Atsushi, Yamada, Kentaro, Katoh, Akira, Kouji, Hiroyuki, Nakamura, Hiroyuki
Published in Scientific reports (16.12.2021)
Published in Scientific reports (16.12.2021)
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DeepCubist: Molecular Generator for Designing Peptidomimetics based on Complex three-dimensional scaffolds
Umedera, Kohei, Yoshimori, Atsushi, Chen, Hengwei, Kouji, Hiroyuki, Nakamura, Hiroyuki, Bajorath, Jürgen
Published in Journal of computer-aided molecular design (01.02.2023)
Published in Journal of computer-aided molecular design (01.02.2023)
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Synthesis of Three‐Dimensional (Di)Azatricyclododecene Scaffold and Its Application to Peptidomimetics
Umedera, Kohei, Morita, Taiki, Yoshimori, Atsushi, Yamada, Kentaro, Katoh, Akira, Kouji, Hiroyuki, Nakamura, Hiroyuki
Published in Chemistry : a European journal (16.08.2021)
Published in Chemistry : a European journal (16.08.2021)
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mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model
Kawase, Haruki, Ago, Yukio, Naito, Megumi, Higuchi, Momoko, Hara, Yuta, Hasebe, Shigeru, Tsukada, Shinji, Kasai, Atsushi, Nakazawa, Takanobu, Mishina, Tadashi, Kouji, Hiroyuki, Takuma, Kazuhiro, Hashimoto, Hitoshi
Published in Pharmacology, biochemistry and behavior (01.01.2019)
Published in Pharmacology, biochemistry and behavior (01.01.2019)
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A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models
Ueda, Hiroshi, Kurita, Jun-ichi, Neyama, Hiroyuki, Hirao, Yuuka, Kouji, Hiroyuki, Mishina, Tadashi, Kasai, Masaji, Nakano, Hirofumi, Yoshimori, Atsushi, Nishimura, Yoshifumi
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
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A novel mRNA decay inhibitor abolishes pathophysiological cellular transition
Kami, Daisuke, Ishizaki, Toshimasa, Taya, Toshihiko, Katoh, Akira, Kouji, Hiroyuki, Gojo, Satoshi
Published in Cell death discovery (07.06.2022)
Published in Cell death discovery (07.06.2022)
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Development of Low-Molecular-Weight Compounds Targeting the Cancer-Associated KLF5 Transcription Factor
Nakaya, Takeo, Aizawa, Kenichi, Taguchi, Yuki, Tsuji, Kentaro, Sekine, Sachi, Murakami, Kazuhiro, Kasai, Masaji, Nakano, Hirofumi, Kondoh, Yasumitsu, Dan, Shingo, Yoshimori, Atsushi, Kouji, Hiroyuki, Takehara, Dai, Suzuki, Toru, Osada, Hiroyuki, Murata, Masayuki, Tanaka, Akira, Nagai, Ryozo
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
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Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells
Doi, Tomomitsu, Hojo, Hironori, Ohba, Shinsuke, Obayashi, Kunie, Endo, Motoyoshi, Ishizaki, Toshimasa, Katoh, Akira, Kouji, Hiroyuki
Published in Heliyon (01.02.2022)
Published in Heliyon (01.02.2022)
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Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis
Matsuda-Hirose, Haruna, Yamate, Tomoko, Goto, Mizuki, Katoh, Akira, Kouji, Hiroyuki, Yamamoto, Yuya, Sakai, Takashi, Uemura, Naoto, Kobayashi, Takashi, Hatano, Yutaka
Published in Annals of dermatology (01.12.2019)
Published in Annals of dermatology (01.12.2019)
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Establishment of an intermittent cold stress model using Tupaia belangeri and evaluation of compound C737 targeting neuron-restrictive silencer factor
Hai-Ying, Chi, Nagano, Kiori, Ezzikouri, Sayeh, Yamaguchi, Chiho, Kayesh, Mohammad Enamul Hoque, Rebbani, Khadija, Kitab, Bouchra, Nakano, Hirohumi, Kouji, Hiroyuki, Kohara, Michinori, Tsukiyama-Kohara, Kyoko
Published in Experimental Animals (2016)
Published in Experimental Animals (2016)
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Follow-up: Prospective compound design using the 'SAR Matrix' method and matrix-derived conditional probabilities of activity [version 2; peer review: 4 approved]
Gupta-Ostermann, Disha, Hirose, Yoichiro, Odagami, Takenao, Kouji, Hiroyuki, Bajorath, Jürgen
Published in F1000 research (15.04.2015)
Published in F1000 research (15.04.2015)
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Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis
Haruna Matsuda-hirose, Tomoko Yamate, Mizuki Goto, Akira Katoh, Hiroyuki Kouji, Yuya Yamamoto, Takashi Sakai, Naoto Uemura, Takashi Kobayashi, Yutaka Hatano
Published in Annals of dermatology (05.12.2019)
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Published in Annals of dermatology (05.12.2019)
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Follow-up: Prospective compound design using the 'SAR Matrix' method and matrix-derived conditional probabilities of activity [version 1; peer review: 3 approved, 1 approved with reservations]
Gupta-Ostermann, Disha, Hirose, Yoichiro, Odagami, Takenao, Kouji, Hiroyuki, Bajorath, Jürgen
Published in F1000 research (2015)
Published in F1000 research (2015)
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Deprotection of the Indole (Nind)-Formyl (For) Group on Tryptophan Employing a New Reagent, N,N′-Dimethylethylendiamine (DMEDA) in an Aqueous Solution
Odagami, Takenao, Tsuda, Yuko, Kogami, Yuji, Kouji, Hiroyuki, Okada, Yoshio
Published in Chemical & Pharmaceutical Bulletin (01.02.2009)
Published in Chemical & Pharmaceutical Bulletin (01.02.2009)
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E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling
Yamada, Kazuhiko, Hori, Yusaku, Inoue, Satoshi, Yamamoto, Yuji, Iso, Kentaro, Kamiyama, Hiroshi, Yamaguchi, Atsumi, Kimura, Takayuki, Uesugi, Mai, Ito, Junichi, Matsuki, Masahiro, Nakamoto, Kazutaka, Harada, Hitoshi, Yoneda, Naoki, Takemura, Atsushi, Kushida, Ikuo, Wakayama, Naomi, Kubara, Kenji, Kato, Yu, Semba, Taro, Yokoi, Akira, Matsukura, Masayuki, Odagami, Takenao, Iwata, Masao, Tsuruoka, Akihiko, Uenaka, Toshimitsu, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenichi, Kouji, Hiroyuki, Owa, Takashi, Funahashi, Yasuhiro, Ozawa, Yoichi
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 Against β-Catenin-activated Hepatocellular Carcinoma
Gabata, Ryosuke, Harada, Kenichi, Mizutani, Yuki, Ouchi, Hirofumi, Yoshimura, Kaori, Sato, Yasunori, Kitao, Azusa, Kimura, Kiminori, Kouji, Hiroyuki, Miyashita, Tomoharu, Tajima, Hidehiro, Ohta, Tetsuo
Published in Anticancer research (01.09.2020)
Published in Anticancer research (01.09.2020)
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The novel inhibitor PRI-724 for Wnt/β-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice
Okazaki, Hiroyasu, Sato, Seidai, Koyama, Kazuya, Morizumi, Shun, Abe, Shuichi, Azuma, Momoyo, Chen, Yajuan, Goto, Hisatsugu, Aono, Yoshinori, Ogawa, Hirohisa, Kagawa, Kozo, Nishimura, Haruka, Kawano, Hiroshi, Toyoda, Yuko, Uehara, Hisanori, Kouji, Hiroyuki, Nishioka, Yasuhiko
Published in Experimental lung research (09.08.2019)
Published in Experimental lung research (09.08.2019)
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Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α
Shimizu, Takahiro, Takahashi, Norihito, Huber, Vincent J., Asawa, Yasunobu, Ueda, Hiroki, Yoshimori, Atsushi, Muramatsu, Yukiko, Seimiya, Hiroyuki, Kouji, Hiroyuki, Nakamura, Hiroyuki, Oguri, Hiroki
Published in Bioorganic & medicinal chemistry (15.01.2021)
Published in Bioorganic & medicinal chemistry (15.01.2021)
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Abstract 5172: E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model
Hori, Yusaku, Yamada, Kazuhiko, Kato, Yu, Ozawa, Yoichi, Odagami, Takenao, Matsui, Junji, Matsushima, Tomohiro, Nomoto, Kenichi, Kouji, Hiroyuki, Owa, Takashi
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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