Cyclodextrin-based sustained and controllable release system of insulin utilizing the combination system of self-assembly PEGylation and polypseudorotaxane formation
Hirotsu, Tatsunori, Higashi, Taishi, Motoyama, Keiichi, Arima, Hidetoshi
Published in Carbohydrate polymers (15.05.2017)
Published in Carbohydrate polymers (15.05.2017)
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Journal Article
Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host–Guest Interaction Surpassing Conventional PEGylation Methods of Proteins
Hirotsu, Tatsunori, Higashi, Taishi, Abu Hashim, Irhan Ibrahim, Misumi, Shogo, Wada, Koki, Motoyama, Keiichi, Arima, Hidetoshi
Published in Molecular pharmaceutics (06.02.2017)
Published in Molecular pharmaceutics (06.02.2017)
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Journal Article
Stabilizing Effects for Antibody Formulations and Safety Profiles of Cyclodextrin Polypseudorotaxane Hydrogels
Higashi, Taishi, Ohshita, Naoko, Hirotsu, Tatsunori, Yamashita, Yoshihito, Motoyama, Keiichi, Koyama, Sawako, Iibuchi, Ruriko, Uchida, Takayuki, Mieda, Shiuhei, Handa, Kenji, Kimoto, Tomoaki, Arima, Hidetoshi
Published in Journal of pharmaceutical sciences (01.05.2017)
Published in Journal of pharmaceutical sciences (01.05.2017)
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Journal Article
Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain
Higashi, Taishi, Kogo, Tetsuya, Sato, Nana, Hirotsu, Tatsunori, Misumi, Shogo, Nakamura, Hideaki, Iohara, Daisuke, Onodera, Risako, Motoyama, Keiichi, Arima, Hidetoshi
Published in ACS applied bio materials (18.05.2020)
Published in ACS applied bio materials (18.05.2020)
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Journal Article
Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels
Higashi, Taishi, Tajima, Anna, Ohshita, Naoko, Hirotsu, Tatsunori, Hashim, Irhan Ibrahim Abu, Motoyama, Keiichi, Koyama, Sawako, Iibuchi, Ruriko, Mieda, Shiuhei, Handa, Kenji, Kimoto, Tomoaki, Arima, Hidetoshi
Published in AAPS PharmSciTech (01.12.2015)
Published in AAPS PharmSciTech (01.12.2015)
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Journal Article
Pharmaceutical properties of insulin conjugate with glucuronylglucosyl-β-cyclodextrin
Sugio, Mari, Hirotsu, Tatsunori, Higashi, Taishi, Motoyama, Keiichi, Hirayama, Fumitoshi, Uekama, Kaneto, Arima, Hidetoshi
Published in Asian journal of pharmceutical sciences (01.02.2016)
Published in Asian journal of pharmceutical sciences (01.02.2016)
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Journal Article
Conversion of raltegravir carrying a 1,3,4-oxadiazole ring to a hydrolysis product upon pH changes decreases its antiviral activity
Nakamura, Tomofumi, Okumura, Mayu, Takamune, Nobutoki, Hirotsu, Tatsunori, Sugiura, Masaharu, Yasunaga, Junichiro, Nakata, Hirotomo
Published in PNAS nexus (01.01.2024)
Published in PNAS nexus (01.01.2024)
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Journal Article
Improvement of pharmaceutical properties of insulin through conjugation with glucuronylglucosyl-β-cyclodextrin
Hirotsu, Tatsunori, Higashi, Taishi, Motoyama, Keiichi, Hirayama, Fumitoshi, Uekama, Kaneto, Arima, Hidetoshi
Published in Journal of inclusion phenomena and macrocyclic chemistry (01.10.2014)
Published in Journal of inclusion phenomena and macrocyclic chemistry (01.10.2014)
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Journal Article
NOVEL PEG-MODIFIED ENZYME AND ANTICANCER AGENT DELIVERY USING SAME
HIGASHI, Taishi, HIROTSU, Tatsunori, MOTOYAMA, Keiichi, ARIMA, Hidetoshi
Year of Publication 16.11.2017
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Year of Publication 16.11.2017
Patent
WITHDRAWN: Self-assembly PEGylation retaining activity of protein drugs via supramolecular complexation with cyclodextrins
Hirotsu, Tatsunori, Higashi, Taishi, Hashim, Irhan Ibrahim Abu, Motoyama, Keiichi, Wada, Koki, Arima, Hidetoshi
Published in Asian journal of pharmceutical sciences (01.11.2015)
Published in Asian journal of pharmceutical sciences (01.11.2015)
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Journal Article