Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
Vicentini, Fernando A, Keenan, Catherine M, Wallace, Laurie E, Woods, Crystal, Cavin, Jean-Baptiste, Flockton, Amanda R, Macklin, Wendy B, Belkind-Gerson, Jaime, Hirota, Simon A, Sharkey, Keith A
Published in Microbiome (26.10.2021)
Published in Microbiome (26.10.2021)
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Journal Article
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
McDonald, Braedon, Pittman, Keir, Menezes, Gustavo B, Hirota, Simon A, Slaba, Ingrid, Waterhouse, Christopher C.M, Beck, Paul L, Muruve, Daniel A, Kubes, Paul
Published in Science (American Association for the Advancement of Science) (15.10.2010)
Published in Science (American Association for the Advancement of Science) (15.10.2010)
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Journal Article
Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota
Nieves, Kristoff M, Hirota, Simon A, Flannigan, Kyle L
Published in American journal of physiology: Gastrointestinal and liver physiology (01.02.2022)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.02.2022)
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Journal Article
Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
Gulbransen, Brian D, Bashashati, Mohammad, Hirota, Simon A, Gui, Xianyong, Roberts, Jane A, MacDonald, Justin A, Muruve, Daniel A, McKay, Derek M, Beck, Paul L, Mawe, Gary M, Thompson, Roger J, Sharkey, Keith A
Published in Nature medicine (01.04.2012)
Published in Nature medicine (01.04.2012)
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Journal Article
Giardia duodenalis infection reduces granulocyte infiltration in an in vivo model of bacterial toxin-induced colitis and attenuates inflammation in human intestinal tissue
Cotton, James A, Motta, Jean-Paul, Schenck, L Patrick, Hirota, Simon A, Beck, Paul L, Buret, Andre G
Published in PloS one (07.10.2014)
Published in PloS one (07.10.2014)
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Journal Article
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
Terc, Joshua, Hansen, Ashleigh, Alston, Laurie, Hirota, Simon A.
Published in European journal of pharmaceutical sciences (13.05.2014)
Published in European journal of pharmaceutical sciences (13.05.2014)
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Journal Article
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
Hirota, Jeremy A., PhD, Hirota, Simon A., PhD, Warner, Stephanie M., BSc, Stefanowicz, Dorota, BSc, Shaheen, Furquan, BSc, Beck, Paul L., MD, PhD, MacDonald, Justin A., PhD, Hackett, Tillie-Louise, PhD, Sin, Don D., MD, Van Eeden, Stephan, MD, Knight, Darryl A., PhD
Published in Journal of allergy and clinical immunology (01.04.2012)
Published in Journal of allergy and clinical immunology (01.04.2012)
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Journal Article
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
El-Daly, Mahmoud, Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, Kang, Sean, Fedak, Paul W.M., Alston, Laurie A., Hirota, Simon A., Ding, Hong, Triggle, Chris R., Hollenberg, Morley D.
Published in Vascular pharmacology (01.10.2018)
Published in Vascular pharmacology (01.10.2018)
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Journal Article
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
VILAYSANE, Akosua, CHUN, Justin, HEMMELGARN, Brenda R, BECK, Paul L, MURUVE, Daniel A, SEAMONE, Mark E, WENJIE WANG, CHIN, Rick, HIROTA, Simon, YAN LI, CLARK, Sharon A, TSCHOPP, Jurg, TRPKOV, Kiril
Published in Journal of the American Society of Nephrology (01.10.2010)
Published in Journal of the American Society of Nephrology (01.10.2010)
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Journal Article
Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice
Miller, Kerri A., Vicentini, Fernando A., Hirota, Simon A., Sharkey, Keith A., Wieser, Michael E.
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2019)
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Journal Article
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation
Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, Tsai, Yi-Cheng, Nieves, Kristoff, Alston, Laurie, Mani, Sridhar, McCoy, Kathy D, Hollenberg, Morley D, Hirota, Simon A
Published in American journal of physiology: endocrinology and metabolism (01.08.2019)
Published in American journal of physiology: endocrinology and metabolism (01.08.2019)
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Journal Article
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Hirota, Simon A., Ng, Jeffrey, Lueng, Alan, Khajah, Maitham, Parhar, Ken, Li, Yan, Lam, Victor, Potentier, Mireille S., Ng, Kelvin, Bawa, Misha, McCafferty, Donna‐Marie, Rioux, Kevin P., Ghosh, Subrata, Xavier, Ramnik J., Colgan, Sean P., Tschopp, Jurg, Muruve, Daniel, MacDonald, Justin A., Beck, Paul L.
Published in Inflammatory bowel diseases (01.06.2011)
Published in Inflammatory bowel diseases (01.06.2011)
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Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77)
Venu, Vivek Krishna Pulakazhi, Saifeddine, Mahmoud, Mihara, Koichiro, Faiza, Muniba, Gorobets, Evgueni, Flewelling, Andrew J., Derksen, Darren J., Hirota, Simon A., Marei, Isra, Al-Majid, Dana, Motahhary, Majid, Ding, Hong, Triggle, Chris R., Hollenberg, Morley D.
Published in Molecular pharmacology (01.11.2021)
Published in Molecular pharmacology (01.11.2021)
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Journal Article
Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation
Vicentini, Fernando A., Szamosi, Jake C., Rossi, Laura, Griffin, Lateece, Nieves, Kristoff, Bihan, Dominique, Lewis, Ian A., Pittman, Quentin J., Swain, Mark G., Surette, Michael G., Hirota, Simon A., Sharkey, Keith A.
Published in Brain, behavior, and immunity (01.05.2022)
Published in Brain, behavior, and immunity (01.05.2022)
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Journal Article
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
Ng, Jeffrey, Hirota, Simon A, Gross, Olaf, Li, Yan, Ulke-Lemee, Annegret, Potentier, Mireille S, Schenck, L Patrick, Vilaysane, Akosua, Seamone, Mark E, Feng, Hanping, Armstrong, Glen D, Tschopp, Jurg, Macdonald, Justin A, Muruve, Daniel A, Beck, Paul L
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2010)
Published in Gastroenterology (New York, N.Y. 1943) (01.08.2010)
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Journal Article
The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins
Erickson, Sarah L., Alston, Laurie, Nieves, Kristoff, Chang, Thomas K. H., Mani, Sridhar, Flannigan, Kyle L., Hirota, Simon A.
Published in The FASEB journal (01.02.2020)
Published in The FASEB journal (01.02.2020)
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Journal Article
Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts
Pulakazhi Venu, Vivek Krishna, Alston, Laurie, Iftinca, Mircea, Tsai, Yi-Cheng, Stephens, Matthew, Warriyar K. V., Vineetha, Rehal, Sonia, Hudson, Grace, Szczepanski, Holly, von der Weid, Pierre-Yves, Altier, Christophe, Hirota, Simon A.
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2021)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2021)
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Journal Article
Behavioural adaptations after antibiotic treatment in male mice are reversed by activation of the aryl hydrocarbon receptor
Vicentini, Fernando A., Mathews, Alexander J., Pittman, Quentin J., Swain, Mark G., Sharkey, Keith A., Hirota, Simon A.
Published in Brain, behavior, and immunity (01.11.2021)
Published in Brain, behavior, and immunity (01.11.2021)
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