Search Results - "Hiroshi TOMIYAMA" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice

by Tahara, Atsuo, Kurosaki, Eiji, Yokono, Masanori, Yamajuku, Daisuke, Kihara, Rumi, Hayashizaki, Yuka, Takasu, Toshiyuki, Imamura, Masakazu, Li, Qun, Tomiyama, Hiroshi, Kobayashi, Yoshinori, Noda, Atsushi, Sasamata, Masao, Shibasaki, Masayuki
Published in European journal of pharmacology (05.09.2013)

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SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats

SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats

by Yokono, Masanori, Takasu, Toshiyuki, Hayashizaki, Yuka, Mitsuoka, Keisuke, Kihara, Rumi, Muramatsu, Yuko, Miyoshi, Sousuke, Tahara, Atsuo, Kurosaki, Eiji, Li, Qun, Tomiyama, Hiroshi, Sasamata, Masao, Shibasaki, Masayuki, Uchiyama, Yasuo
Published in European journal of pharmacology (15.03.2014)

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Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats

Effects of sodium-glucose cotransporter 2 selective inhibitor ipragliflozin on hyperglycaemia, oxidative stress, inflammation and liver injury in streptozotocin-induced type 1 diabetic rats

by Tahara, Atsuo, Kurosaki, Eiji, Yokono, Masanori, Yamajuku, Daisuke, Kihara, Rumi, Hayashizaki, Yuka, Takasu, Toshiyuki, Imamura, Masakazu, Li, Qun, Tomiyama, Hiroshi, Kobayashi, Yoshinori, Noda, Atsushi, Sasamata, Masao, Shibasaki, Masayuki
Published in Journal of pharmacy and pharmacology (01.07.2014)

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Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats

Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats

by Wada, Yusuke, Kondo, Mitsuhiro, Sakairi, Kumi, Nagashima, Akira, Tokita, Kenichi, Tominaga, Hiroaki, Tomiyama, Hiroshi, Ishikawa, Tomohisa
Published in The Journal of pharmacology and experimental therapeutics (01.09.2020)

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Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo

by Tahara, Atsuo, Kurosaki, Eiji, Yokono, Masanori, Yamajuku, Daisuke, Kihara, Rumi, Hayashizaki, Yuka, Takasu, Toshiyuki, Imamura, Masakazu, Qun, Li, Tomiyama, Hiroshi, Kobayashi, Yoshinori, Noda, Atsushi, Sasamata, Masao, Shibasaki, Masayuki
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.04.2012)

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Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin–Nicotinamide-Induced Mildly Diabetic Mice

Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin–Nicotinamide-Induced Mildly Diabetic Mice

by Tahara, Atsuo, Kurosaki, Eiji, Yokono, Masanori, Yamajuku, Daisuke, Kihara, Rumi, Hayashizaki, Yuka, Takasu, Toshiyuki, Imamura, Masakazu, Qun, Li, Tomiyama, Hiroshi, Kobayashi, Yoshinori, Noda, Atsushi, Sasamata, Masao, Shibasaki, Masayuki
Published in Journal of Pharmacological Sciences (2012)

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Regioselective Alkylation of 2-Alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones

Regioselective Alkylation of 2-Alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones

by Sonegawa, Motoharu, Yokota, Masayuki, Tomiyama, Hiroshi, Tomiyama, Tsuyoshi
Published in Chemical & Pharmaceutical Bulletin (2006)

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Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin^|^ndash;Nicotinamide-Induced Mildly Diabetic Mice

Antidiabetic Effects of SGLT2-Selective Inhibitor Ipragliflozin in Streptozotocin^|^ndash;Nicotinamide-Induced Mildly Diabetic Mice

by Tahara, Atsuo, Kurosaki, Eiji, Yokono, Masanori, Yamajuku, Daisuke, Kihara, Rumi, Hayashizaki, Yuka, Takasu, Toshiyuki, Imamura, Masakazu, Qun, Li, Tomiyama, Hiroshi, Kobayashi, Yoshinori, Noda, Atsushi, Sasamata, Masao, Shibasaki, Masayuki
Published in Journal of pharmacological sciences (2012)

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Effective Preparation of Cycloheptimidazol-4-one Compounds

Effective Preparation of Cycloheptimidazol-4-one Compounds

by Sonegawa, Motoharu, Iwai, Yoshinori, Tomiyama, Hiroshi, Tomiyama, Tsuyoshi
Published in Chemical & Pharmaceutical Bulletin (2006)

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Nitrous oxide can enhance the hypnotic effect, but not the suppression of spinal motor neuron excitability by propofol in humans

Nitrous oxide can enhance the hypnotic effect, but not the suppression of spinal motor neuron excitability by propofol in humans

by Kakinohana, Manabu, Miyata, Yuji, Tomiyama, Hiroshi, Sugahara, Kazuhiro
Published in Journal of anesthesia (20.08.2006)

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Effects of the SGLT2 inhibitor ipragliflozin on food intake, appetite-regulating hormones, and arteriovenous differences in postprandial glucose levels in type 2 diabetic rats

Effects of the SGLT2 inhibitor ipragliflozin on food intake, appetite-regulating hormones, and arteriovenous differences in postprandial glucose levels in type 2 diabetic rats

by Tahara, Atsuo, Kondo, Yoshinori, Takasu, Toshiyuki, Tomiyama, Hiroshi
Published in Biomedicine & pharmacotherapy (01.09.2018)

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Catalytic asymmetric intramolecular cyclopropanation of enol silyl ether. Synthesis of the phorbol CD-ring skeleton

Catalytic asymmetric intramolecular cyclopropanation of enol silyl ether. Synthesis of the phorbol CD-ring skeleton

by Tokunoh, Ryosuke, Tomiyama, Hiroshi, Sodeoka, Mikiko, Shibasaki, Masakatsu
Published in Tetrahedron letters (01.04.1996)

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Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

Discovery of ASP5878: Synthesis and structure–activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity

by Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Terasaka, Tadashi, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Kikuchi, Aya, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.04.2022)

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Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2

by Kuriwaki, Ikumi, Kameda, Minoru, Hisamichi, Hiroyuki, Kikuchi, Shigetoshi, Iikubo, Kazuhiko, Kawamoto, Yuichiro, Moritomo, Hiroyuki, Kondoh, Yutaka, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Suzuki, Tomoyuki, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (15.05.2020)

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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors

by Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro
Published in Bioorganic & medicinal chemistry (15.04.2019)

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Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

by Imamura, Masakazu, Nakanishi, Keita, Suzuki, Takayuki, Ikegai, Kazuhiro, Shiraki, Ryota, Ogiyama, Takashi, Murakami, Takeshi, Kurosaki, Eiji, Noda, Atsushi, Kobayashi, Yoshinori, Yokota, Masayuki, Koide, Tomokazu, Kosakai, Kazuhiro, Ohkura, Yasufumi, Takeuchi, Makoto, Tomiyama, Hiroshi, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (15.05.2012)

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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

by Kuriwaki, Ikumi, Kameda, Minoru, Iikubo, Kazuhiko, Hisamichi, Hiroyuki, Kawamoto, Yuichiro, Kikuchi, Shigetoshi, Moritomo, Hiroyuki, Kondoh, Yutaka, Terasaka, Tadashi, Amano, Yasushi, Tateishi, Yukihiro, Echizen, Yuka, Iwai, Yoshinori, Noda, Atsushi, Tomiyama, Hiroshi, Nakazawa, Taisuke, Hirano, Masaaki
Published in Bioorganic & medicinal chemistry (01.03.2021)

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Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543

by Ikegai, Kazuhiro, Imamura, Masakazu, Suzuki, Takayuki, Nakanishi, Keita, Murakami, Takeshi, Kurosaki, Eiji, Noda, Atsushi, Kobayashi, Yoshinori, Yokota, Masayuki, Koide, Tomokazu, Kosakai, Kazuhiro, Ohkura, Yasufumi, Takeuchi, Makoto, Tomiyama, Hiroshi, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (01.07.2013)

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Synthesis of a C-Glycoside Analogue of sTn: An HIV- and Tumor-Associated Antigen

Synthesis of a C-Glycoside Analogue of sTn: An HIV- and Tumor-Associated Antigen

by Kuberan, Balagurunathan, Sikkander, Sulthan A., Tomiyama, Hiroshi, Linhardt, Robert J.
Published in Angewandte Chemie International Edition (09.05.2003)

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Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor

Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor

by Yokono, Masanori, Tahara, Atsuo, Kurosaki, Eiji, Yamajuku, Daisuke, Kihara, Rumi, Imamura, Masakazu, Tomiyama, Hiroshi, Kobayashi, Yoshinori, Noda, Atsushi, Shibasaki, Masayuki
Published in Endocrine research (01.08.2013)

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