A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J., Lendy, Emma K., Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A., Kodama, Eiichi N., Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D., Ghosh, Arun K., Mitsuya, Hiroaki
Published in Nature communications (28.01.2021)
Published in Nature communications (28.01.2021)
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Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
Tsukada, Kento, Shinki, Shono, Kaneko, Akiho, Murakami, Kazuma, Irie, Kazuhiro, Murai, Masatoshi, Miyoshi, Hideto, Dan, Shingo, Kawaji, Kumi, Hayashi, Hironori, Kodama, Eiichi N., Hori, Aki, Salim, Emil, Kuraishi, Takayuki, Hirata, Naoya, Kanda, Yasunari, Asai, Teigo
Published in Nature communications (14.04.2020)
Published in Nature communications (14.04.2020)
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Freshwater mussels (Bivalvia: Unionidae) from the rising sun (Far East Asia): phylogeny, systematics, and distribution
Lopes-Lima, Manuel, Hattori, Akimasa, Kondo, Takaki, Hee Lee, Jin, Ki Kim, Sang, Shirai, Akihisa, Hayashi, Hironori, Usui, Taira, Sakuma, Kanta, Toriya, Taishi, Sunamura, Youhei, Ishikawa, Haruki, Hoshino, Naoki, Kusano, Yushi, Kumaki, Hinata, Utsugi, Yuya, Yabe, Shinnosuke, Yoshinari, Yuma, Hiruma, Hazuki, Tanaka, Akiko, Sao, Kentaro, Ueda, Takuya, Sano, Isao, Miyazaki, Jun-Ichi, Gonçalves, Duarte V., Klishko, Olga K., Konopleva, Ekaterina S., Vikhrev, Ilya V., Kondakov, Alexander V., Yu. Gofarov, Mikhail, Bolotov, Ivan N., Sayenko, Elena M., Soroka, Marianna, Zieritz, Alexandra, Bogan, Arthur E., Froufe, Elsa
Published in Molecular phylogenetics and evolution (01.05.2020)
Published in Molecular phylogenetics and evolution (01.05.2020)
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Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib‐sensitive and ‐resistant multiple myeloma cells
Nishimura, Nao, Radwan, Mohamed O., Amano, Masayuki, Endo, Shinya, Fujii, Eri, Hayashi, Hironori, Ueno, Shikiko, Ueno, Niina, Tatetsu, Hiro, Hata, Hiroyuki, Okamoto, Yoshinari, Otsuka, Masami, Mitsuya, Hiroaki, Matsuoka, Masao, Okuno, Yutaka
Published in Cancer science (01.10.2019)
Published in Cancer science (01.10.2019)
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Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602
Ohata, Yoshitsugu, Tomonaga, Mitsunori, Watanabe, Yasuo, Tomura, Keiko, Kimura, Koji, Akaki, Tatsuo, Adachi, Kaoru, Kodama, Eiichi N, Matsuzaki, Yuji, Hayashi, Hironori
Published in Journal of virology (23.03.2022)
Published in Journal of virology (23.03.2022)
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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Published in Scientific reports (30.06.2020)
Published in Scientific reports (30.06.2020)
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Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance
Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K, Mitsuya, Hiroaki
Published in mBio (06.03.2018)
Published in mBio (06.03.2018)
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Conversion hepatectomy for advanced hepatocellular carcinoma after right portal vein transection and lenvatinib therapy
Ohya, Yuki, Hayashida, Shintaro, Tsuji, Akira, Kuramoto, Kunitaka, Shibata, Hidekatsu, Setoyama, Hiroko, Hayashi, Hironori, Kuriwaki, Kazumi, Sasaki, Masato, Iizaka, Masayoshi, Nakahara, Osamu, Inomata, Yukihiro
Published in Surgical case reports (10.12.2020)
Published in Surgical case reports (10.12.2020)
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Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5
Oikawa, Yoshitsugu, Izumi, Rumiko, Koide, Masashi, Hagiwara, Yoshihiro, Kanzaki, Makoto, Suzuki, Naoki, Kikuchi, Koichi, Matsuhashi, Tetsuro, Akiyama, Yukako, Ichijo, Mariko, Watanabe, Shun, Toyohara, Takafumi, Suzuki, Takehiro, Mishima, Eikan, Akiyama, Yasutoshi, Ogata, Yoshiaki, Suzuki, Chitose, Hayashi, Hironori, Kodama, Eiichi N, Hayashi, Ken-Ichiro, Itoi, Eiji, Aoki, Masashi, Kure, Shigeo, Abe, Takaaki
Published in PloS one (02.12.2020)
Published in PloS one (02.12.2020)
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Synthesis and Cytotoxicity of Cyclic Octapeptide Surugamides with Varied N-Acyl Moieties
Matsuda, Kenichi, Niikura, Shinya, Ichihara, Rintaro, Fujita, Kei, Strasser, Anna M., Yoshikawa, Rokusuke, Yasuda, Jiro, Hiramatsu, Yoshiki, Hayashi, Hironori, Kodama, Eiichi N., Wakimoto, Toshiyuki
Published in Chemical & pharmaceutical bulletin (20.09.2024)
Published in Chemical & pharmaceutical bulletin (20.09.2024)
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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Published in eLife (17.10.2017)
Published in eLife (17.10.2017)
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Detour canal, a civil engineering heritage created through historical struggle for water resources, now provides the habitats for a rare freshwater fish
Yamasaki, Yohei, Hayashi, Hironori, Kubo, Suguru, Namiki, Takashi, Kano, Yuichi
Published in Biodiversity data journal (27.06.2024)
Published in Biodiversity data journal (27.06.2024)
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Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation
MAWATARI, TOSHIKI, NINOMIYA, ITASU, INOKUCHI, MASAFUMI, HARADA, SHINICHI, HAYASHI, HIRONORI, OYAMA, KATSUNOBU, MAKINO, ISAMU, NAKAGAWARA, HISATOSHI, MIYASHITA, TOMOHARU, TAJIMA, HIDEHIRO, TAKAMURA, HIROYUKI, FUSHIDA, SACHIO, OHTA, TETSUO
Published in International journal of oncology (01.12.2015)
Published in International journal of oncology (01.12.2015)
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Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir
Hayashi, Hironori, Takamune, Nobutoki, Nirasawa, Takashi, Aoki, Manabu, Morishita, Yoshihiko, Das, Debananda, Koh, Yasuhiro, Ghosh, Arun K., Misumi, Shogo, Mitsuya, Hiroaki
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies
Ghosh, Arun K, Williams, Jacqueline N, Ho, Rachel Y, Simpson, Hannah M, Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir
Nakagawara, Kohsuke, Hayashi, Hironori, Kawaji, Kumi, Sasano, Mina, Kodama, Eiichi N
Published in Antiviral chemistry & chemotherapy (2020)
Published in Antiviral chemistry & chemotherapy (2020)
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Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications
Amano, Masayuki, Salcedo-Gómez, Pedro Miguel, Yedidi, Ravikiran S, Zhao, Rui, Hayashi, Hironori, Hasegawa, Kazuya, Nakamura, Tomofumi, Martyr, Cuthbert D, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Antimicrobial agents and chemotherapy (01.07.2019)
Published in Antimicrobial agents and chemotherapy (01.07.2019)
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Platelets surrounding primary tumor cells are related to chemoresistance
Ishikawa, Satoko, Miyashita, Tomoharu, Inokuchi, Masafumi, Hayashi, Hironori, Oyama, Katsunobu, Tajima, Hidehiro, Takamura, Hironori, Ninomiya, Itasu, Ahmed, A. Karim, Harman, John W, Fushida, Sachio, Ohta, Tetsuo
Published in Oncology reports (01.08.2016)
Published in Oncology reports (01.08.2016)
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Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2
Higashi-Kuwata, Nobuyo, Tsuji, Kohei, Hayashi, Hironori, Bulut, Haydar, Kiso, Maki, Imai, Masaki, Ogata-Aoki, Hiromi, Ishii, Takahiro, Kobayakawa, Takuya, Nakano, Kenta, Takamune, Nobutoki, Kishimoto, Naoki, Hattori, Shin-ichiro, Das, Debananda, Uemura, Yukari, Shimizu, Yosuke, Aoki, Manabu, Hasegawa, Kazuya, Suzuki, Satoshi, Nishiyama, Akie, Saruwatari, Junji, Shimizu, Yukiko, Sukenaga, Yoshikazu, Takamatsu, Yuki, Tsuchiya, Kiyoto, Maeda, Kenji, Yoshimura, Kazuhisa, Iida, Shun, Ozono, Seiya, Suzuki, Tadaki, Okamura, Tadashi, Misumi, Shogo, Kawaoka, Yoshihiro, Tamamura, Hirokazu, Mitsuya, Hiroaki
Published in Nature communications (25.02.2023)
Published in Nature communications (25.02.2023)
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Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space
Miyata, Takashi, Tajima, Hidehiro, Hirata, Miki, Nakanuma, Shin‐ichi, Makino, Isamu, Hayashi, Hironori, Oyama, Katsunobu, Miyashita, Tomoharu, Takamura, Hiroyuki, Ninomiya, Itasu, Fushida, Sachio, Iseki, Shoichi, Harada, Shin‐ichi, Wakayama, Tomohiko, Ohta, Tetsuo
Published in Journal of gastroenterology and hepatology (01.04.2018)
Published in Journal of gastroenterology and hepatology (01.04.2018)
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