Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts
Yip, Hon Yan Kelvin, Tan, Chin Wee, Hirokawa, Yumiko, Burgess, Antony Wilks
Published in PloS one (21.06.2018)
Published in PloS one (21.06.2018)
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Journal Article
Wnt signalling pathway parameters for mammalian cells
Tan, Chin Wee, Gardiner, Bruce S, Hirokawa, Yumiko, Layton, Meredith J, Smith, David W, Burgess, Antony W
Published in PloS one (21.02.2012)
Published in PloS one (21.02.2012)
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Journal Article
Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1−/− mice
Low, Jun T., Ho, Gwo-Yaw, Scott, Mark, Tan, Chin Wee, Whitehead, Lachlan, Barber, Kathy, Yip, Hon Y. K., Dekkers, Johanna F., Hirokawa, Yumiko, Silke, John, Burgess, Antony W., Strasser, Andreas, Putoczki, Tracy L., O’Reilly, Lorraine A.
Published in Cell death & disease (17.11.2021)
Published in Cell death & disease (17.11.2021)
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Journal Article
Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestine
Hirokawa, Yumiko, Clarke, Jordan, Palmieri, Michelle, Tan, Tao, Mouradov, Dmitri, Li, Shan, Lin, Cong, Li, Fuqiang, Luo, Huijuan, Wu, Kui, Faux, Maree, Tan, Chin Wee, Lee, Margaret, Gard, Grace, Gibbs, Peter, Burgess, Antony W., Sieber, Oliver M.
Published in Communications biology (13.09.2021)
Published in Communications biology (13.09.2021)
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Journal Article
Low-viscosity Matrix Suspension Culture for Human Colorectal Epithelial Organoids and Tumoroids
Tan, Tao, Hirokawa, Yumiko, Clarke, Jordan, Sakthianandeswaren, Anuratha, Sieber, Oliver M
Published in Bio-protocol (20.04.2022)
Published in Bio-protocol (20.04.2022)
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Journal Article
Defining the susceptibility of colorectal cancers to BH3-mimetic compounds
Luo, Ming-Jie, Palmieri, Michelle, Riffkin, Chris D., Sakthianandeswaren, Anuratha, Djajawi, Tirta Mario, Hirokawa, Yumiko, Shuttleworth, Victoria, Segal, David H., White, Christine A., Nhu, Duong, Lessene, Guillaume, Lee, Margaret, Gibbs, Peter, Huang, David C. S., Sieber, Oliver M., Gong, Jia-nan
Published in Cell death & disease (10.09.2020)
Published in Cell death & disease (10.09.2020)
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Journal Article
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer
Nguyen, Paul M., Dagley, Laura F., Preaudet, Adele, Lam, Nga, Giam, Maybelline, Fung, Ka Yee, Aizel, Kaheina, van Duijneveldt, Gemma, Tan, Chin Wee, Hirokawa, Yumiko, Yip, Hon Yan K., Love, Christopher G., Poh, Ashleigh R., Cruz, Akshay D’, Burstroem, Charlotte, Feltham, Rebecca, Abdirahman, Suad M., Meiselbach, Kristy, Low, Ronnie Ren Jie, Palmieri, Michelle, Ernst, Matthias, Webb, Andrew I., Burgess, Tony, Sieber, Oliver M., Bouillet, Philippe, Putoczki, Tracy L.
Published in Cell death and differentiation (01.02.2020)
Published in Cell death and differentiation (01.02.2020)
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Journal Article
Colon cryptogenesis: asymmetric budding
Tan, Chin Wee, Hirokawa, Yumiko, Gardiner, Bruce S, Smith, David W, Burgess, Antony W
Published in PloS one (21.10.2013)
Published in PloS one (21.10.2013)
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Journal Article
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
Buchert, Michael, Rohde, Franziska, Eissmann, Moritz, Tebbutt, Niall, Williams, Ben, Tan, Chin Wee, Owen, Alexander, Hirokawa, Yumiko, Gnann, Alexandra, Orend, Gertraud, Orner, Gayle, Dashwood, Rod H, Heath, Joan K, Ernst, Matthias, Janssen, Klaus-Peter
Published in Disease models & mechanisms (01.11.2015)
Published in Disease models & mechanisms (01.11.2015)
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Journal Article
Signal therapy of human pancreatic cancer and NF1 -deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)
Hirokawa, Yumiko, Levitzki, Alexander, Lessene, Guillaume, Baell, Jonathan, Xiao, Yi, Zhu, Hongjian, Maruta, Hiroshi
Published in Cancer letters (08.01.2007)
Published in Cancer letters (08.01.2007)
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Journal Article
Signal therapy of breast cancers by the HDAC inhibitor FK228 that blocks the activation of PAK1 and abrogates the tamoxifen-resistance
Hirokawa, Yumiko, Arnold, Melissa, Nakajima, Hidenori, Zalcberg, John, Maruta, Hiroshi
Published in Cancer biology & therapy (01.09.2005)
Published in Cancer biology & therapy (01.09.2005)
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Journal Article
Sichuan pepper extracts block the PAK1/Cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice
Hirokawa, Yumiko, Nheu, Thao, Grimm, Kirsten, Mautner, Victor, Maeda, Satoko, Yoshida, Minoru, Komiyama, Kanki, Kluwe, Lan, Maruta, Hiroshi
Published in Cancer biology & therapy (01.03.2006)
Published in Cancer biology & therapy (01.03.2006)
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Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?
Garg, Mayur, Royce, Simon G, Tikellis, Chris, Shallue, Claire, Batu, Duygu, Velkoska, Elena, Burrell, Louise M, Patel, Sheila K, Beswick, Lauren, Jackson, Anvesh, Britto, Kaushali, Lukies, Matthew, Sluka, Pavel, Wardan, Hady, Hirokawa, Yumiko, Tan, Chin Wee, Faux, Maree, Burgess, Antony W, Hosking, Patrick, Monagle, Shaun, Thomas, Merlin, Gibson, Peter R, Lubel, John
Published in Gut (01.05.2020)
Published in Gut (01.05.2020)
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Journal Article
The Tyr-Kinase Inhibitor AG879, that Blocks the ETK-PAK1 Interaction, Suppresses the RAS-induced PAK1 Activation and Malignant Transformation
He, Hong, Hirokawa, Yumiko, Gazit, Aviv, Yamashita, Yoshihiro, Mano, Hiroyuki, Kawakami, Yuko, Kawakami, Toshiaki, Hsieh, Ching-Yi, Kung, Hsing-Jien, Lessene, Guillaume, Baell, Jonathan, Levitzki, Alexander, Maruta, Hiroshi
Published in Cancer biology & therapy (01.01.2004)
Published in Cancer biology & therapy (01.01.2004)
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Journal Article
PAK Is Essential for RAS-Induced Upregulation of Cyclin D1 During the G1 to S Transition
Nheu, Thao, He, Hong, Hirokawa, Yumiko, Walker, Francesca, Wood, John, Maruta, Hiroshi
Published in Cell cycle (Georgetown, Tex.) (01.01.2004)
Published in Cell cycle (Georgetown, Tex.) (01.01.2004)
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Journal Article
FORECAST-1: Feasibility of organoid response assessment to define effective treatments for patients with colorectal cancer after failure of standard therapy
Gard, Grace, Lee, Margaret, Hirokawa, Yumiko, Tie, Jeanne, Clarke, Jordan, Tebbutt, Niall C., Tan, Tao, Jalali, Azim, Mouradov, Dmitri, Lee, Belinda, Sieber, Oliver, Gibbs, Peter
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Journal Article
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
Wang, Zilu, Burigotto, Matteo, Ghetti, Sabrina, Vaillant, François, Tan, Tao, Capaldo, Bianca D, Palmieri, Michelle, Hirokawa, Yumiko, Tai, Lin, Simpson, Daniel S, Chang, Catherine, Huang, Allan Shuai, Lieschke, Elizabeth, Diepstraten, Sarah T, Kaloni, Deeksha, Riffkin, Chris, Huang, David C S, Li Wai Suen, Connie S N, Garnham, Alexandra L, Gibbs, Peter, Visvader, Jane E, Sieber, Oliver M, Herold, Marco J, Fava, Luca L, Kelly, Gemma L, Strasser, Andreas
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
Tan, Tao, Mouradov, Dmitri, Lee, Margaret, Gard, Grace, Hirokawa, Yumiko, Li, Shan, Lin, Cong, Li, Fuqiang, Luo, Huijuan, Wu, Kui, Palmieri, Michelle, Leong, Evelyn, Clarke, Jordan, Sakthianandeswaren, Anuratha, Brasier, Helen, Tie, Jeanne, Tebbutt, Niall C, Jalali, Azim, Wong, Rachel, Burgess, Antony W, Gibbs, Peter, Sieber, Oliver M
Published in Cell reports. Medicine (19.12.2023)
Published in Cell reports. Medicine (19.12.2023)
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