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Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo
Sakamoto, Kotaro, Masutani, Teruaki, Hirokawa, Takatsugu
Published in Scientific Reports (10.12.2020)
Published in Scientific Reports (10.12.2020)
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Ubiquitin is phosphorylated by PINK1 to activate parkin
Koyano, Fumika, Okatsu, Kei, Kosako, Hidetaka, Tamura, Yasushi, Go, Etsu, Kimura, Mayumi, Kimura, Yoko, Tsuchiya, Hikaru, Yoshihara, Hidehito, Hirokawa, Takatsugu, Endo, Toshiya, Fon, Edward A., Trempe, Jean-François, Saeki, Yasushi, Tanaka, Keiji, Matsuda, Noriyuki
Published in Nature (London) (05.06.2014)
Published in Nature (London) (05.06.2014)
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Pocket to concavity: a tool for the refinement of protein–ligand binding site shape from alpha spheres
Kudo, Genki, Hirao, Takumi, Yoshino, Ryunosuke, Shigeta, Yasuteru, Hirokawa, Takatsugu
Published in Bioinformatics (03.04.2023)
Published in Bioinformatics (03.04.2023)
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Site Identification and Next Choice Protocol for Hit-to-Lead Optimization
Kudo, Genki, Hirao, Takumi, Yoshino, Ryunosuke, Shigeta, Yasuteru, Hirokawa, Takatsugu
Published in Journal of Chemical Information and Modeling (10.06.2024)
Published in Journal of Chemical Information and Modeling (10.06.2024)
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Biological Evaluation of Isosteric Applicability of 1,3‐Substituted Cuneanes as m‐Substituted Benzenes Enabled by Selective Isomerization of 1,4‐Substituted Cubanes
Fujiwara, Kan, Nagasawa, Shota, Maeyama, Ryusei, Segawa, Ryosuke, Hirasawa, Noriyasu, Hirokawa, Takatsugu, Iwabuchi, Yoshiharu
Published in Chemistry : a European journal (21.02.2024)
Published in Chemistry : a European journal (21.02.2024)
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Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
Ohashi, Hirofumi, Watashi, Koichi, Saso, Wakana, Shionoya, Kaho, Iwanami, Shoya, Hirokawa, Takatsugu, Shirai, Tsuyoshi, Kanaya, Shigehiko, Ito, Yusuke, Kim, Kwang Su, Nomura, Takao, Suzuki, Tateki, Nishioka, Kazane, Ando, Shuji, Ejima, Keisuke, Koizumi, Yoshiki, Tanaka, Tomohiro, Aoki, Shin, Kuramochi, Kouji, Suzuki, Tadaki, Hashiguchi, Takao, Maenaka, Katsumi, Matano, Tetsuro, Muramatsu, Masamichi, Saijo, Masayuki, Aihara, Kazuyuki, Iwami, Shingo, Takeda, Makoto, McKeating, Jane A., Wakita, Takaji
Published in iScience (23.04.2021)
Published in iScience (23.04.2021)
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The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
Sekiya, Motohiro, Kainoh, Kenta, Sugasawa, Takehito, Yoshino, Ryunosuke, Hirokawa, Takatsugu, Tokiwa, Hiroaki, Nakano, Shogo, Nagatoishi, Satoru, Tsumoto, Kouhei, Takeuchi, Yoshinori, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi
Published in Nature communications (02.11.2021)
Published in Nature communications (02.11.2021)
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Receptor mechanism producing a sweet taste from plant aroma compounds
Horie, Fuyumi, Sanematsu, Keisuke, Yasumatsu, Keiko, Hirokawa, Takatsugu, Shigemura, Noriatsu, Yamashita, Atsuko, Kusakabe, Yuko
Published in Scientific reports (12.03.2025)
Published in Scientific reports (12.03.2025)
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Modeling the structure of the transmembrane domain of T1R3, a subunit of the sweet taste receptor, with neohesperidin dihydrochalcone using molecular dynamics simulation
Nakagita, Tomoya, Matsuya, Takumi, Narukawa, Masataka, Kobayashi, Takuya, Hirokawa, Takatsugu, Misaka, Takumi
Published in Bioscience, biotechnology, and biochemistry (21.11.2023)
Published in Bioscience, biotechnology, and biochemistry (21.11.2023)
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Regulation of thrombin activity by ligand-induced topological alteration in a thrombin-binding aptamer
Sasaki, Shogo, Ma, Yue, Hirokawa, Takatsugu, Ikebukuro, Kazunori, Tera, Masayuki, Nagasawa, Kazuo
Published in Chemical communications (Cambridge, England) (13.07.2023)
Published in Chemical communications (Cambridge, England) (13.07.2023)
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Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor
Nakagita, Tomoya, Ishida, Akiko, Matsuya, Takumi, Kobayashi, Takuya, Narukawa, Masataka, Hirokawa, Takatsugu, Hashimoto, Makoto, Misaka, Takumi
Published in PloS one (18.03.2019)
Published in PloS one (18.03.2019)
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2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition
Fukasawa, Keiko, Gotoh, Mari, Uwamizu, Akiharu, Hirokawa, Takatsugu, Ishikawa, Masaki, Shimizu, Yoshibumi, Yamamoto, Shinji, Iwasa, Kensuke, Yoshikawa, Keisuke, Aoki, Junken, Murakami-Murofushi, Kimiko
Published in Scientific reports (30.08.2021)
Published in Scientific reports (30.08.2021)
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