Primary Human Hepatocyte Spheroid Model as a 3D In Vitro Platform for Metabolism Studies
Kanebratt, Kajsa P., Janefeldt, Annika, Vilén, Liisa, Vildhede, Anna, Samuelsson, Kristin, Milton, Lucas, Björkbom, Anders, Persson, Marie, Leandersson, Carina, Andersson, Tommy B., Hilgendorf, Constanze
Published in Journal of pharmaceutical sciences (01.01.2021)
Published in Journal of pharmaceutical sciences (01.01.2021)
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Journal Article
Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines
HILGENDORF, Constanze, AHLIN, Gustav, SEITHEL, Annick, ARTURSSON, Per, UNGELL, Anna-Lena, KARLSSON, Johan
Published in Drug metabolism and disposition (01.08.2007)
Published in Drug metabolism and disposition (01.08.2007)
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Journal Article
Structural and conformational determinants of macrocycle cell permeability
Over, Björn, Matsson, Pär, Tyrchan, Christian, Artursson, Per, Doak, Bradley C, Foley, Michael A, Hilgendorf, Constanze, Johnston, Stephen E, Lee, 4th, Maurice D, Lewis, Richard J, McCarren, Patrick, Muncipinto, Giovanni, Norinder, Ulf, Perry, Matthew W D, Duvall, Jeremy R, Kihlberg, Jan
Published in Nature chemical biology (01.12.2016)
Published in Nature chemical biology (01.12.2016)
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Journal Article
Excised segments of rat small intestine in Ussing chamber studies: A comparison of native and stripped tissue viability and permeability to drugs
Sjögren, Erik, Eriksson, Johanna, Vedin, Charlotta, Breitholtz, Katarina, Hilgendorf, Constanze
Published in International journal of pharmaceutics (30.05.2016)
Published in International journal of pharmaceutics (30.05.2016)
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Journal Article
Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties
Over, Björn, McCarren, Patrick, Artursson, Per, Foley, Michael, Giordanetto, Fabrizio, Grönberg, Gunnar, Hilgendorf, Constanze, Lee, Maurice D, Matsson, Pär, Muncipinto, Giovanni, Pellisson, Mélanie, Perry, Matthew W. D, Svensson, Richard, Duvall, Jeremy R, Kihlberg, Jan
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination
Jones, Christopher R., Hatley, Oliver J. D., Ungell, Anna-Lena, Hilgendorf, Constanze, Peters, Sheila Annie, Rostami-Hodjegan, Amin
Published in The AAPS journal (01.05.2016)
Published in The AAPS journal (01.05.2016)
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Journal Article
Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
Seithel, Annick, Karlsson, Johan, Hilgendorf, Constanze, Björquist, Anna, Ungell, Anna-Lena
Published in European journal of pharmaceutical sciences (01.07.2006)
Published in European journal of pharmaceutical sciences (01.07.2006)
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Journal Article
Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis
Nilsson, Anna, Peric, Alexandra, Strimfors, Marie, Goodwin, Richard J A, Hayes, Martin A, Andrén, Per E, Hilgendorf, Constanze
Published in Scientific reports (25.07.2017)
Published in Scientific reports (25.07.2017)
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Journal Article
Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs
AHLIN, Gustav, HILGENDORF, Constanze, KARLSSON, Johan, AL-KHALILI SZIGYARTO, Cristina, UHLEN, Mathias, ARTURSSON, Per
Published in Drug metabolism and disposition (01.12.2009)
Published in Drug metabolism and disposition (01.12.2009)
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Journal Article
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Hayeshi, Rose, Hilgendorf, Constanze, Artursson, Per, Augustijns, Patrick, Brodin, Birger, Dehertogh, Pascale, Fisher, Karen, Fossati, Lina, Hovenkamp, Egbert, Korjamo, Timo, Masungi, Chantal, Maubon, Nathalie, Mols, Raf, Müllertz, Anette, Mönkkönen, Jukka, O’Driscoll, Caitriona, Oppers-Tiemissen, H.M., Ragnarsson, Eva G.E., Rooseboom, Martijn, Ungell, Anna-Lena
Published in European journal of pharmaceutical sciences (18.12.2008)
Published in European journal of pharmaceutical sciences (18.12.2008)
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Journal Article
Development of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport Function
MILIOTIS, Tasso, ALI, Liaqat, PALM, Johan E, LUNDQVIST, Anders J, AHNOFF, Martin, ANDERSSON, Tommy B, HILGENDORF, Constanze
Published in Drug metabolism and disposition (01.12.2011)
Published in Drug metabolism and disposition (01.12.2011)
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Journal Article
Development of a primary human hepatocyte spheroid culture model for drug metabolism and disposition studies
Kanebratt, Kajsa P., Janefeldt, Annika, Peric, Alexandra, Jonsson, Julia, Johansson, Linnea, Hilgendorf, Constanze, Andersson, Tommy B.
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein–Protein Interaction
Cheng, Leifeng, Pettersen, Daniel, Ohlsson, Bengt, Schell, Peter, Karle, Michael, Evertsson, Emma, Pahlén, Sara, Jonforsen, Maria, Plowright, Alleyn T, Boström, Jonas, Fex, Tomas, Thelin, Anders, Hilgendorf, Constanze, Xue, Yafeng, Wahlund, Göran, Lindberg, Walter, Larsson, Lars-Olof, Gustafsson, David
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
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Journal Article
Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations
VAN DE KERKHOF, Esther G, UNGELL, Anna-Lena B, SJÖBERG, Asa K, DE JAGER, Marina H, HILGENDORF, Constanze, DE GRAAF, Inge A. M, GROOTHUIS, Geny M. M
Published in Drug metabolism and disposition (01.11.2006)
Published in Drug metabolism and disposition (01.11.2006)
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Journal Article
Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells
Brännström, Marie, Nordell, Pär, Bonn, Britta, Davis, Andrew M, Palmgren, Anna-Pia, Hilgendorf, Constanze, Rubin, Katarina, Grime, Ken
Published in Pharmaceutics (15.12.2015)
Published in Pharmaceutics (15.12.2015)
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Journal Article
Characterization of Binding Properties to Human P-Glycoprotein: Development of a [3H]Verapamil Radioligand-Binding Assay
Doppenschmitt, S, Langguth, P, Regardh, CG, Andersson, TB, Hilgendorf, C, Spahn-Langguth, H
Published in The Journal of pharmacology and experimental therapeutics (01.01.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1999)
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Industry Perspective on Therapeutic Peptide Drug–Drug Interaction Assessments During Drug Development: A European Federation of Pharmaceutical Industries and Associations White Paper
Säll, Carolina, Argikar, Upendra, Fonseca, Kari, Hilgendorf, Constanze, Lopes, Filipe, Riedel, Jens, Schiller, Hilmar, Sonesson, Anders, Umehara, Kenichi, Wang, Kai
Published in Clinical pharmacology and therapeutics (01.06.2023)
Published in Clinical pharmacology and therapeutics (01.06.2023)
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In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters
Gopaul, V Sashi, Vildhede, Anna, Andersson, Tommy B, Erlandsson, Fredrik, Lee, Caroline A, Johansson, Susanne, Hilgendorf, Constanze
Published in The Journal of pharmacology and experimental therapeutics (01.08.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2021)
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