EGFR inhibition reverses resistance to lenvatinib in hepatocellular carcinoma cells
He, Xiaoping, Hikiba, Yohko, Suzuki, Yoshimasa, Nakamori, Yoshinori, Kanemaru, Yushi, Sugimori, Makoto, Sato, Takeshi, Nozaki, Akito, Chuma, Makoto, Maeda, Shin
Published in Scientific reports (14.05.2022)
Published in Scientific reports (14.05.2022)
Get full text
Journal Article
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity
Fujiwara, Naoto, Nakagawa, Hayato, Enooku, Kenichiro, Kudo, Yotaro, Hayata, Yuki, Nakatsuka, Takuma, Tanaka, Yasuo, Tateishi, Ryosuke, Hikiba, Yohko, Misumi, Kento, Tanaka, Mariko, Hayashi, Akimasa, Shibahara, Junji, Fukayama, Masashi, Arita, Junichi, Hasegawa, Kiyoshi, Hirschfield, Hadassa, Hoshida, Yujin, Hirata, Yoshihiro, Otsuka, Motoyuki, Tateishi, Keisuke, Koike, Kazuhiko
Published in Gut (01.08.2018)
Published in Gut (01.08.2018)
Get full text
Journal Article
NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice
Maeda, Shin, Hikiba, Yohko, Fujiwara, Hiroaki, Ikenoue, Tsuneo, Sue, Soichiro, Sugimori, Makoto, Matsubayashi, Mao, Kaneko, Hiroaki, Irie, Kuniyasu, Sasaki, Tomohiko, Chuma, Makoto
Published in Cancer science (01.04.2021)
Published in Cancer science (01.04.2021)
Get full text
Journal Article
Constitutive NF-κB Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth
SAKAMOTO, Kei, MAEDA, Shin, HIKIBA, Yohko, NAKAGAWA, Hayato, HAYAKAWA, Yoku, SHIBATA, Wataru, YANAI, Ayako, OGURA, Keiji, OMATA, Masao
Published in Clinical cancer research (01.04.2009)
Published in Clinical cancer research (01.04.2009)
Get full text
Journal Article
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands
Nakagawa, Hayato, Suzuki, Nobumi, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Kinoshita, Hiroto, Ihara, Sozaburo, Uchino, Koji, Nishikawa, Yuji, Ijichi, Hideaki, Otsuka, Motoyuki, Arita, Junichi, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Kokudo, Norihiro, Tateishi, Keisuke, Koike, Kazuhiko
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (09.05.2017)
Get full text
Journal Article
Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium
Kinoshita, Hiroto, Hayakawa, Yoku, Konishi, Mitsuru, Hata, Masahiro, Tsuboi, Mayo, Hayata, Yuki, Hikiba, Yohko, Ihara, Sozaburo, Nakagawa, Hayato, Ikenoue, Tsuneo, Ushiku, Tetsuo, Fukayama, Masashi, Hirata, Yoshihiro, Koike, Kazuhiko
Published in The Journal of pathology (01.01.2019)
Published in The Journal of pathology (01.01.2019)
Get full text
Journal Article
Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis
Nakagawa, Hayato, Hikiba, Yohko, Hirata, Yoshihiro, Font-Burgada, Joan, Sakamoto, Kei, Hayakawa, Yoku, Taniguchi, Koji, Umemura, Atsushi, Kinoshita, Hiroto, Sakitani, Kosuke, Nishikawa, Yuji, Hirano, Kenji, Ikenoue, Tsuneo, Ijichi, Hideaki, Dhar, Debanjan, Shibata, Wataru, Akanuma, Masao, Koike, Kazuhiko, Karin, Michael, Maeda, Shin
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2014)
Get full text
Journal Article
BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice
Hayakawa, Yoku, Tsuboi, Mayo, Asfaha, Samuel, Kinoshita, Hiroto, Niikura, Ryota, Konishi, Mitsuru, Hata, Masahiro, Oya, Yukiko, Kim, Woosook, Middelhoff, Moritz, Hikiba, Yohko, Higashijima, Naoko, Ihara, Sozaburo, Ushiku, Tetsuo, Fukayama, Masashi, Tailor, Yagnesh, Hirata, Yoshihiro, Guha, Chandan, Yan, Kelley S., Koike, Kazuhiko, Wang, Timothy C.
Published in Gastroenterology (New York, N.Y. 1943) (01.03.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.03.2019)
Get full text
Journal Article
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
Nakagawa, Hayato, Maeda, Shin, Hikiba, Yohko, Ohmae, Tomoya, Shibata, Wataru, Yanai, Ayako, Sakamoto, Kei, Ogura, Keiji, Noguchi, Takuya, Karin, Michael, Ichijo, Hidenori, Omata, Masao
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2008)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2008)
Get more information
Journal Article
A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion
Ikenoue, Tsuneo, Terakado, Yumi, Nakagawa, Hayato, Hikiba, Yohko, Fujii, Tomoaki, Matsubara, Daisuke, Noguchi, Rei, Zhu, Chi, Yamamoto, Keisuke, Kudo, Yotaro, Asaoka, Yoshinari, Yamaguchi, Kiyoshi, Ijichi, Hideaki, Tateishi, Keisuke, Fukushima, Noriyoshi, Maeda, Shin, Koike, Kazuhiko, Furukawa, Yoichi
Published in Scientific reports (01.04.2016)
Published in Scientific reports (01.04.2016)
Get full text
Journal Article
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis
Kinoshita, Hiroto, Hirata, Yoshihiro, Nakagawa, Hayato, Sakamoto, Kei, Hayakawa, Yoku, Takahashi, Ryota, Nakata, Wachiko, Sakitani, Kosuke, Serizawa, Takako, Hikiba, Yohko, Akanuma, Masao, Shibata, Wataru, Maeda, Shin, Koike, Kazuhiko
Published in PloS one (12.04.2013)
Published in PloS one (12.04.2013)
Get full text
Journal Article
Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice
Shibata, Wataru, Kinoshita, Hiroto, Hikiba, Yohko, Sato, Takeshi, Ishii, Yasuaki, Sue, Soichiro, Sugimori, Makoto, Suzuki, Nobumi, Sakitani, Kosuke, Ijichi, Hideaki, Mori, Ryutaro, Endo, Itaru, Maeda, Shin
Published in Scientific reports (18.04.2018)
Published in Scientific reports (18.04.2018)
Get full text
Journal Article
Apoptosis signal‐regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor‐suppressing function of stress‐activated mitogen‐activated protein kinase
Nakagawa, Hayato, Hirata, Yoshihiro, Takeda, Kohsuke, Hayakawa, Yoku, Sato, Takehiro, Kinoshita, Hiroto, Sakamoto, Kei, Nakata, Wachiko, Hikiba, Yohko, Omata, Masao, Yoshida, Haruhiko, Koike, Kazuhiko, Ichijo, Hidenori, Maeda, Shin
Published in Hepatology (Baltimore, Md.) (01.07.2011)
Published in Hepatology (Baltimore, Md.) (01.07.2011)
Get full text
Journal Article
Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress
Sakitani, Kosuke, Hirata, Yoshihiro, Hikiba, Yohko, Hayakawa, Yoku, Ihara, Sozaburo, Suzuki, Hirobumi, Suzuki, Nobumi, Serizawa, Takako, Kinoshita, Hiroto, Sakamoto, Kei, Nakagawa, Hayato, Tateishi, Keisuke, Maeda, Shin, Ikenoue, Tsuneo, Kawazu, Shoji, Koike, Kazuhiko
Published in BMC cancer (24.10.2015)
Published in BMC cancer (24.10.2015)
Get full text
Journal Article
Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease
Ihara, Sozaburo, Hirata, Yoshihiro, Hikiba, Yohko, Yamashita, Aya, Tsuboi, Mayo, Hata, Masahiro, Konishi, Mitsuru, Suzuki, Nobumi, Sakitani, Kosuke, Kinoshita, Hiroto, Hayakawa, Yoku, Nakagawa, Hayato, Ijichi, Hideaki, Tateishi, Keisuke, Koike, Kazuhiko
Published in Journal of Crohn's and colitis (09.11.2018)
Published in Journal of Crohn's and colitis (09.11.2018)
Get full text
Journal Article
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer
Hayakawa, Yoku, Hirata, Yoshihiro, Nakagawa, Hayato, Sakamoto, Kei, Hikiba, Yohko, Kinoshita, Hiroto, Nakata, Wachiko, Takahashi, Ryota, Tateishi, Keisuke, Tada, Motohisa, Akanuma, Masao, Yoshida, Haruhiko, Takeda, Kohsuke, Ichijo, Hidenori, Omata, Masao, Maeda, Shin, Koike, Kazuhiko, Karin, Michael
Published in Proceedings of the National Academy of Sciences - PNAS (11.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (11.01.2011)
Get full text
Journal Article
Therapeutic effect of c‐Jun N‐terminal kinase inhibition on pancreatic cancer
Takahashi, Ryota, Hirata, Yoshihiro, Sakitani, Kosuke, Nakata, Wachiko, Kinoshita, Hiroto, Hayakawa, Yoku, Nakagawa, Hayato, Sakamoto, Kei, Hikiba, Yohko, Ijichi, Hideaki, Moses, Harold L., Maeda, Shin, Koike, Kazuhiko
Published in Cancer science (01.03.2013)
Published in Cancer science (01.03.2013)
Get full text
Journal Article
Functional analysis of PIK3CA gene mutations in human colorectal cancer
IKENOUE, Tsuneo, KANAI, Fumihiko, ASAOKA, Yoshinari, MATSUMURA, Masayuki, KAWABE, Takao, OMATA, Masao, HIKIBA, Yohko, OBATA, Toshiyuki, TANAKA, Yasuo, IMAMURA, Jun, OHTA, Miki, JAZAG, Amarsanaa, GULENG, Bayasi, TATEISHI, Keisuke
Published in Cancer research (Chicago, Ill.) (01.06.2005)
Published in Cancer research (Chicago, Ill.) (01.06.2005)
Get full text
Journal Article
c‐Jun N‐terminal kinase in pancreatic tumor stroma augments tumor development in mice
Sato, Takeshi, Shibata, Wataru, Hikiba, Yohko, Kaneta, Yoshihiro, Suzuki, Nobumi, Ihara, Sozaburo, Ishii, Yasuaki, Sue, Soichiro, Kameta, Eri, Sugimori, Makoto, Yamada, Hiroaki, Kaneko, Hiroaki, Sasaki, Tomohiko, Ishii, Tomohiro, Tamura, Toshihide, Kondo, Masaaki, Maeda, Shin
Published in Cancer science (01.11.2017)
Published in Cancer science (01.11.2017)
Get full text
Journal Article
C-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice
SHIBATA, Wataru, MAEDA, Shin, HIKIBA, Yohko, YANAI, Ayako, SAKAMOTO, Kei, NAKAGAWA, Hayato, OGURA, Keiji, KARIN, Michael, OMATA, Masao
Published in Cancer research (Chicago, Ill.) (01.07.2008)
Published in Cancer research (Chicago, Ill.) (01.07.2008)
Get full text
Journal Article