Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
Lawlor, Kynan T., Vanslambrouck, Jessica M., Higgins, J. William, Chambon, Alison, Bishard, Kristina, Arndt, Derek, Er, Pei Xuan, Wilson, Sean B., Howden, Sara E., Tan, Ker Sin, Li, Fanyi, Hale, Lorna J., Shepherd, Benjamin, Pentoney, Stephen, Presnell, Sharon C., Chen, Alice E., Little, Melissa H.
Published in Nature materials (01.02.2021)
Published in Nature materials (01.02.2021)
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Journal Article
Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics
Zamek-Gliszczynski, Maciej J, Bedwell, David W, Bao, Jing Q, Higgins, J William
Published in Drug metabolism and disposition (01.09.2012)
Published in Drug metabolism and disposition (01.09.2012)
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Journal Article
Prediction of renal transporter mediated drug-drug interactions for pemetrexed using physiologically based pharmacokinetic modeling
Posada, Maria M, Bacon, James A, Schneck, Karen B, Tirona, Rommel G, Kim, Richard B, Higgins, J William, Pak, Y Anne, Hall, Stephen D, Hillgren, Kathleen M
Published in Drug metabolism and disposition (01.03.2015)
Published in Drug metabolism and disposition (01.03.2015)
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Journal Article
Prediction of Transporter‐Mediated Drug‐Drug Interactions for Baricitinib
Posada, Maria M., Cannady, Ellen A., Payne, Christopher D., Zhang, Xin, Bacon, James A., Pak, Y. Anne, Higgins, J. William, Shahri, Nazila, Hall, Stephen D., Hillgren, Kathleen M.
Published in Clinical and translational science (01.11.2017)
Published in Clinical and translational science (01.11.2017)
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Journal Article
Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1
Higgins, J William, Ke, Alice B, Zamek-Gliszczynski, Maciej J
Published in Drug metabolism and disposition (01.11.2014)
Published in Drug metabolism and disposition (01.11.2014)
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Journal Article
Rhodamine Inhibitors of P-Glycoprotein: An Amide/Thioamide “Switch” for ATPase Activity
Gannon, Michael K, Holt, Jason J, Bennett, Stephanie M, Wetzel, Bryan R, Loo, Tip W, Bartlett, M. Claire, Clarke, David M, Sawada, Geri A, Higgins, J. William, Tombline, Gregory, Raub, Thomas J, Detty, Michael R
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Journal Article
Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics
Higgins, J William, Bedwell, David W, Zamek-Gliszczynski, Maciej J
Published in Drug metabolism and disposition (01.06.2012)
Published in Drug metabolism and disposition (01.06.2012)
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Journal Article
3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing
King, Shelby M, Higgins, J William, Nino, Celina R, Smith, Timothy R, Paffenroth, Elizabeth H, Fairbairn, Casey E, Docuyanan, Abigail, Shah, Vishal D, Chen, Alice E, Presnell, Sharon C, Nguyen, Deborah G
Published in Frontiers in physiology (08.03.2017)
Published in Frontiers in physiology (08.03.2017)
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Journal Article
Chalcogenopyrylium dyes as inhibitors/modulators of P-glycoprotein in multidrug-resistant cells
Sawada, Geri A., Raub, Thomas J., William Higgins, J., Brennan, Nancy K., Moore, Teiah M., Tombline, Gregory, Detty, Michael R.
Published in Bioorganic & medicinal chemistry (15.11.2008)
Published in Bioorganic & medicinal chemistry (15.11.2008)
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Journal Article
Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human
Coe, Kevin J., Feinstein, Mark, Higgins, J. William, Leung, Perry, Scott, Brian P., Skaptason, Judy, Tam, Yuen, Volak, Laurie P., Kinong, Jennifer, Bittner, Anton, McAllister, Heather, Lim, Nathan M., Hack, Michael, Koudriakova, Tatiana
Published in Drug metabolism and disposition (01.08.2022)
Published in Drug metabolism and disposition (01.08.2022)
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Journal Article
Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein
Higgins, J William, Bao, Jing Q, Ke, Alice B, Manro, Jason R, Fallon, John K, Smith, Philip C, Zamek-Gliszczynski, Maciej J
Published in Drug metabolism and disposition (01.01.2014)
Published in Drug metabolism and disposition (01.01.2014)
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Journal Article
3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing
King, Shelby M., Higgins, J. William, Nino, Celina R., Smith, Timothy R., Paffenroth, Elizabeth H., Fairbairn, Casey E., Docuyanan, Abigail, Shah, Vishal D., Chen, Alice E., Presnell, Sharon C., Nguyen, Deborah G.
Published in Frontiers in physiology (08.03.2017)
Published in Frontiers in physiology (08.03.2017)
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Journal Article
Expanding Access to Clinical Services for Toddlers with Autism Spectrum Disorders
Mathews, Therese L., Lugo, Ashley M., King, Melissa L., Needelman, Laura L., McArdle, Paige E., Romer, Natalie, Terry, Megan, Menousek, Kathryn, Evans, Joseph H., Higgins, William J.
Published in Journal of pediatric health care (01.03.2018)
Published in Journal of pediatric health care (01.03.2018)
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