N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins
Higel, Fabian, Seidl, Andreas, Sörgel, Fritz, Friess, Wolfgang
Published in European journal of pharmaceutics and biopharmaceutics (01.03.2016)
Published in European journal of pharmaceutics and biopharmaceutics (01.03.2016)
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Journal Article
Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing
Baumeister, Julia, Meudt, Maximilian, Ebert, Sybille, Rosenau, Frank, Mizaikoff, Boris, Blech, Michaela, Aertker, Kristina M J, Higel, Fabian
Published in mAbs (31.12.2024)
Published in mAbs (31.12.2024)
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Journal Article
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
Voss, Matthias, Künzel, Ulrike, Higel, Fabian, Kuhn, Peer-Hendrik, Colombo, Alessio, Fukumori, Akio, Haug-Kröper, Martina, Klier, Bärbel, Grammer, Gudula, Seidl, Andreas, Schröder, Bernd, Obst, Reinhard, Steiner, Harald, Lichtenthaler, Stefan F, Haass, Christian, Fluhrer, Regina
Published in The EMBO journal (17.12.2014)
Published in The EMBO journal (17.12.2014)
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Journal Article
The structure-function relationship of disulfide bonds in etanercept
Lamanna, William C, Mayer, Robert Ernst, Rupprechter, Alfred, Fuchs, Michael, Higel, Fabian, Fritsch, Cornelius, Vogelsang, Cornelia, Seidl, Andreas, Toll, Hansjoerg, Schiestl, Martin, Holzmann, Johann
Published in Scientific reports (21.06.2017)
Published in Scientific reports (21.06.2017)
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Journal Article
CE methods for charge variant analysis of mAbs and complex format biotherapeutics
Meudt, Maximilian, Pannek, Martin, Glogowski, Nina, Higel, Fabian, Thanisch, Katharina, Knape, Matthias J.
Published in Electrophoresis (01.08.2024)
Published in Electrophoresis (01.08.2024)
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Journal Article
Comprehensive analysis and characterization of glycan pairing in therapeutic antibodies and Fc-containing biotherapeutics: Addressing current limitations and implications for N-glycan impact
Meudt, Maximilian, Baumeister, Julia, Mizaikoff, Boris, Ebert, Sybille, Rosenau, Frank, Blech, Michaela, Higel, Fabian
Published in European journal of pharmaceutics and biopharmaceutics (01.07.2024)
Published in European journal of pharmaceutics and biopharmaceutics (01.07.2024)
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Journal Article
N-glycans of complex glycosylated biopharmaceuticals and their impact on protein clearance
Higel, Fabian, Sandl, Theresa, Kao, Chi-Ya, Pechinger, Nicole, Sörgel, Fritz, Friess, Wolfgang, Wolschin, Florian, Seidl, Andreas
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2019)
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2019)
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Journal Article
Towards maximum acceleration of monoclonal antibody development: Leveraging transposase-mediated cell line generation to enable GMP manufacturing within 3 months using a stable pool
Schmieder, Valerie, Fieder, Juergen, Drerup, Raphael, Gutierrez, Erik Arango, Guelch, Carina, Stolzenberger, Jessica, Stumbaum, Mihaela, Mueller, Volker Steffen, Higel, Fabian, Bergbauer, Martin, Bornhoefft, Kim, Wittner, Manuel, Gronemeyer, Petra, Braig, Christian, Huber, Michaela, Reisenauer-Schaupp, Anita, Mueller, Markus Michael, Schuette, Mark, Puengel, Sebastian, Lindner, Benjamin, Schmidt, Moritz, Schulz, Patrick, Fischer, Simon
Published in Journal of biotechnology (10.04.2022)
Published in Journal of biotechnology (10.04.2022)
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Journal Article
N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical
Higel, Fabian, Seidl, Andreas, Demelbauer, Uwe, Viertlboeck-Schudy, Margot, Koppenburg, Vera, Kronthaler, Ulrich, Sörgel, Fritz, Frieß, Wolfgang
Published in Pharmaceutical research (01.11.2015)
Published in Pharmaceutical research (01.11.2015)
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