A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Hattori, Shin-Ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J, Lendy, Emma K, Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A, Kodama, Eiichi N, Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Nature communications (28.01.2021)
Published in Nature communications (28.01.2021)
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Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
Hayashi, Sanae, Isogawa, Masanori, Kawashima, Keigo, Ito, Kyoko, Chuaypen, Natthaya, Morine, Yuji, Shimada, Mitsuo, Higashi-Kuwata, Nobuyo, Watanabe, Takehisa, Tangkijvanich, Pisit, Mitsuya, Hiroaki, Tanaka, Yasuhito
Published in Scientific reports (08.02.2022)
Published in Scientific reports (08.02.2022)
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Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma
Maeda, Kenji, Higashi-Kuwata, Nobuyo, Kinoshita, Noriko, Kutsuna, Satoshi, Tsuchiya, Kiyoto, Hattori, Shin-Ichiro, Matsuda, Kouki, Takamatsu, Yuki, Gatanaga, Hiroyuki, Oka, Shinichi, Sugiyama, Haruhito, Ohmagari, Norio, Mitsuya, Hiroaki
Published in Scientific reports (10.03.2021)
Published in Scientific reports (10.03.2021)
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Effects of a novel hepatitis B anti-viral drug E-CFCP in renal organic acid transporters
Ishibane, Misaki, Hashimoto, Hirofumi, Kaneko, Meika, Saito, Shota, Pae, Sangjon, Saito, Shinpei, Reien, Yoshie, Hirayama, Yuri, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Anzai, Naohiko
Published in Journal of pharmacological sciences (01.12.2022)
Published in Journal of pharmacological sciences (01.12.2022)
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4′‐modified nucleoside analogs: Potent inhibitors active against entecavir‐resistant hepatitis B virus
Takamatsu, Yuki, Tanaka, Yasuhito, Kohgo, Satoru, Murakami, Shuko, Singh, Kamalendra, Das, Debananda, Venzon, David J., Amano, Masayuki, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Delino, Nicole S., Hayashi, Sanae, Takahashi, Satoru, Sukenaga, Yoshikazu, Haraguchi, Kazuhiro, Sarafianos, Stefan G., Maeda, Kenji, Mitsuya, Hiroaki
Published in Hepatology (Baltimore, Md.) (01.10.2015)
Published in Hepatology (Baltimore, Md.) (01.10.2015)
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Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands
Ghosh, Arun K., Kovela, Satish, Sharma, Ashish, Shahabi, Dana, Ghosh, Ajay K., Hopkins, Denver R., Yadav, Monika, Johnson, Megan E., Agniswamy, Johnson, Wang, Yuan‐Fang, Hattori, Shin‐Ichiro, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (04.05.2022)
Published in ChemMedChem (04.05.2022)
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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Published in eLife (17.10.2017)
Published in eLife (17.10.2017)
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Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron
Amano, Masayuki, Otsu, Sachiko, Uemura, Yukari, Ichikawa, Yasuko, Matsumoto, Shota, Higashi-Kuwata, Nobuyo, Matsushita, Shuzo, Shimada, Shinya, Mitsuya, Hiroaki
Published in Scientific reports (13.10.2023)
Published in Scientific reports (13.10.2023)
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Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
Yamasaki, Satoshi, Yagishita, Naoko, Sasaki, Takeshi, Nakazawa, Minako, Kato, Yukihiro, Yamadera, Tadayuki, Bae, Eunkyung, Toriyama, Sayumi, Ikeda, Rie, Zhang, Lei, Fujitani, Kazuko, Yoo, Eunkyung, Tsuchimochi, Kaneyuki, Ohta, Tomohiko, Araya, Natsumi, Fujita, Hidetoshi, Aratani, Satoko, Eguchi, Katsumi, Komiya, Setsuro, Maruyama, Ikuro, Higashi, Nobuyo, Sato, Mitsuru, Senoo, Haruki, Ochi, Takahiro, Yokoyama, Shigeyuki, Amano, Tetsuya, Kim, Jaeseob, Gay, Steffen, Fukamizu, Akiyoshi, Nishioka, Kusuki, Tanaka, Keiji, Nakajima, Toshihiro
Published in The EMBO journal (10.01.2007)
Published in The EMBO journal (10.01.2007)
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Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters
Takamatsu, Yuki, Imai, Masaki, Maeda, Kenji, Nakajima, Noriko, Higashi-Kuwata, Nobuyo, Iwatsuki-Horimoto, Kiyoko, Ito, Mutsumi, Kiso, Maki, Maemura, Tadashi, Takeda, Yuichiro, Omata, Kazumi, Suzuki, Tadaki, Kawaoka, Yoshihiro, Mitsuya, Hiroaki
Published in Journal of virology (23.02.2022)
Published in Journal of virology (23.02.2022)
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Structure–Activity Relationship Studies of SARS-CoV‑2 Main Protease Inhibitors Containing 4‑Fluorobenzothiazole-2-carbonyl Moieties
Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Shinohara, Kouki, Azuma, Chika, Miura, Yutaro, Nakano, Hiroki, Wada, Naoya, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV
Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Kumamoto, Hiroki, Ogata-Aoki, Hiromi, Das, Debananda, Venzon, David, Hattori, Shin-ichiro, Bulut, Haydar, Hashimoto, Mai, Otagiri, Masaki, Takamune, Nobutoki, Kishimoto, Naoki, Davis, David A., Misumi, Shogo, Kakuni, Masakazu, Tanaka, Yasuhito, Mitsuya, Hiroaki
Published in Journal of hepatology (01.05.2021)
Published in Journal of hepatology (01.05.2021)
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Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2
Higashi-Kuwata, Nobuyo, Tsuji, Kohei, Hayashi, Hironori, Bulut, Haydar, Kiso, Maki, Imai, Masaki, Ogata-Aoki, Hiromi, Ishii, Takahiro, Kobayakawa, Takuya, Nakano, Kenta, Takamune, Nobutoki, Kishimoto, Naoki, Hattori, Shin-ichiro, Das, Debananda, Uemura, Yukari, Shimizu, Yosuke, Aoki, Manabu, Hasegawa, Kazuya, Suzuki, Satoshi, Nishiyama, Akie, Saruwatari, Junji, Shimizu, Yukiko, Sukenaga, Yoshikazu, Takamatsu, Yuki, Tsuchiya, Kiyoto, Maeda, Kenji, Yoshimura, Kazuhisa, Iida, Shun, Ozono, Seiya, Suzuki, Tadaki, Okamura, Tadashi, Misumi, Shogo, Kawaoka, Yoshihiro, Tamamura, Hirokazu, Mitsuya, Hiroaki
Published in Nature communications (25.02.2023)
Published in Nature communications (25.02.2023)
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Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation
Higashi-Kuwata, Nobuyo, Yabe, Shigeharu G, Fukuda, Satsuki, Nishida, Junko, Tamura-Nakano, Miwa, Hattori, Shin-Ichiro, Okochi, Hitoshi, Mitsuya, Hiroaki
Published in Microbiology spectrum (21.12.2022)
Published in Microbiology spectrum (21.12.2022)
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Potent and biostable inhibitors of the main protease of SARS-CoV-2
Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Azuma, Chika, Nakayama, Miyuki, Onishi, Takato, Nakano, Hiroki, Wada, Naoya, Hori, Miki, Shinohara, Kouki, Miura, Yutaro, Kawada, Takuma, Hayashi, Hironori, Hattori, Shin-ichiro, Bulut, Haydar, Das, Debananda, Takamune, Nobutoki, Kishimoto, Naoki, Saruwatari, Junji, Okamura, Tadashi, Nakano, Kenta, Misumi, Shogo, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Synthesis, Anti-HBV, and Anti-HIV Activities of 3′-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines
Kumamoto, Hiroki, Imoto, Shuhei, Amano, Masayuki, Kuwata-Higashi, Nobuyo, Baba, Masanori, Mitsuya, Hiroaki, Odanaka, Yuki, Shimbara Matsubayashi, Satoko, Tanaka, Hiromichi, Haraguchi, Kazuhiro
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice
Higashi-Kuwata, Nobuyo, Ogata-Aoki, Hiromi, Hattori, Shin-ichiro, Hayashi, Hironori, Danish, Matthew, Aoki, Manabu, Shiotsu, Chiemi, Kawamura, Tatsuyoshi, Ihn, Hironobu, Kobayashi, Hisataka, Okada, Seiji, Mitsuya, Hiroaki
Published in Antiviral research (01.08.2017)
Published in Antiviral research (01.08.2017)
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Journal Article
Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement
Tsuji, Kohei, Kobayakawa, Takuya, Ishii, Takahiro, Higashi-Kuwata, Nobuyo, Azuma, Chika, Shinohara, Kouki, Miura, Yutaro, Yamamoto, Kenichi, Nishimura, Soshi, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in Chemical & pharmaceutical bulletin (01.12.2023)
Published in Chemical & pharmaceutical bulletin (01.12.2023)
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Synthesis of 4′‐Substituted Purine 2′‐Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus
Kohgo, Satoru, Imoto, Shuhei, Tokuda, Ryoh, Takamatsu, Yuki, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Amano, Masayuki, Kansui, Hisao, Onitsuka, Kengo, Maeda, Kenji, Mitsuya, Hiroaki
Published in ChemistrySelect (Weinheim) (22.03.2018)
Published in ChemistrySelect (Weinheim) (22.03.2018)
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