Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase
Selness, Shaun R, Devraj, Rajesh V, Devadas, Balekudru, Walker, John K, Boehm, Terri L, Durley, Richard C, Shieh, Huey, Xing, Li, Rucker, Paul V, Jerome, Kevin D, Benson, Alan G, Marrufo, Laura D, Madsen, Heather M, Hitchcock, Jeff, Owen, Tom J, Christie, Lance, Promo, Michele A, Hickory, Brian S, Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika, Messing, Dean, Yang, Jerry, Mao, Michael K, Yalamanchili, Gopi, Vonder Embse, Richard, Hirsch, Jeffrey, Saabye, Matthew, Bonar, Sheri, Webb, Elizabeth, Anderson, Gary, Monahan, Joseph B
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
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Journal Article
Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase
Selness, Shaun R., Devraj, Rajesh V., Monahan, Joseph B., Boehm, Terri L., Walker, John K., Devadas, Balekudru, Durley, Richard C., Kurumbail, Ravi, Shieh, Huey, Xing, Li, Hepperle, Michael, Rucker, Paul V., Jerome, Kevin D., Benson, Alan G., Marrufo, Laura D., Madsen, Heather M., Hitchcock, Jeff, Owen, Tom J., Christie, Lance, Promo, Michele A., Hickory, Brian S., Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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Journal Article
Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase
Selness, Shaun R, Boehm, Terri L, Walker, John K, Devadas, Balekudru, Durley, Richard C, Kurumbail, Ravi, Shieh, Huey, Xing, Li, Hepperle, Michael, Rucker, Paul V, Jerome, Kevin D, Benson, Alan G, Marrufo, Laura D, Madsen, Heather M, Hitchcock, Jeff, Owen, Tom J, Christie, Lance, Promo, Michele A, Hickory, Brian S, Alvira, Edgardo, Naing, Win, Blevis-Bal, Radhika, Devraj, Rajesh V, Messing, Dean, Schindler, John F, Hirsch, Jeffrey, Saabye, Matthew, Bonar, Sheri, Webb, Elizabeth, Anderson, Gary, Monahan, Joseph B
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
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Journal Article
Discovery of a Simple Picomolar Inhibitor of Cholesteryl Ester Transfer Protein
Reinhard, Emily J, Wang, Jane L, Durley, Richard C, Fobian, Yvette M, Grapperhaus, Margaret L, Hickory, Brian S, Massa, Mark A, Norton, Monica B, Promo, Michele A, Tollefson, Michael B, Vernier, William F, Connolly, Daniel T, Witherbee, Bryan J, Melton, Michele A, Regina, Karen J, Smith, Mark E, Sikorski, James A
Published in Journal of medicinal chemistry (22.05.2003)
Published in Journal of medicinal chemistry (22.05.2003)
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Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein
Massa, Mark A., Spangler, Dale P., Durley, Richard C., Hickory, Brian S., Connolly, Daniel T., Witherbee, Bryan J., Smith, Mark E., Sikorski, James A.
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
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Chiral N,N-Disubstituted Trifluoro-3-Amino-2-Propanols Are Potent Inhibitors of Cholesteryl Ester Transfer Protein
Durley, Richard C, Grapperhaus, Margaret L, Hickory, Brian S, Massa, Mark A, Wang, Jane L, Spangler, Dale P, Mischke, Deborah A, Parnas, Barry L, Fobian, Yvette M, Rath, Nigam P, Honda, Dorothy D, Zeng, Ming, Connolly, Daniel T, Heuvelman, Deborah M, Witherbee, Bryan J, Melton, Michele A, Glenn, Kevin C, Krul, Elaine S, Smith, Mark E, Sikorski, James A
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE
MADSEN HEATHER M, NAING WIN, WALKER JOHN, DEVRAJ RAJESH, PROMO MICHELE A, MCGEE KEVIN F, DURLEY RICHARD C, BLEVIS-BAL RADHIKA M, OWEN THOMAS, SELNESS SHAUN R, ALVIRA EDGARDO, SHIEH HUEY S, JEROME KEVIN D, BOEHM TERRI L, LIU SHUANG, HITCHCOCK JEFF, SAMBANDAM ARUNA, DEVADAS BALEKUDRU, HICKORY BRIAN S, SCOTT IAN L, MARRUFO LAURA D, RUCKER PAUL V, XING LI
Year of Publication 30.01.2015
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Year of Publication 30.01.2015
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ΥΠΟΚΑΤΕΣΤΗΜΕΝΕΣ ΠΥΡΙΔΙΝΟΝΕΣ ΩΣ ΡΥΘΜΙΣΤΕΣ ΤΗΣ Ρ38 ΜΑΡ ΚΙΝΑΣΗΣ
MADSEN HEATHER M, NAING WIN, WALKER JOHN, DEVRAJ RAJESH, PROMO MICHELE A, MCGEE KEVIN F, DURLEY RICHARD C, BLEVIS-BAL RADHIKA M, OWEN THOMAS, SELNESS SHAUN R, ALVIRA EDGARDO, SHIEH HUEY S, JEROME KEVIN D, BOEHM TERRI L, LIU SHUANG, HITCHCOCK JEFF, SAMBANDAM ARUNA, DEVADAS BALEKUDRU, HICKORY BRIAN S, SCOTT IAN L, MARRUFO LAURA D, RUCKER PAUL V, XING LI
Year of Publication 13.08.2014
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Year of Publication 13.08.2014
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SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE
SELNESS, SHAUN R, NAING, WIN, DURLEY, RICHARD C, WALKER, JOHN, HITCHCOCK, JEFF, SCOTT, IAN L, PROMO, MICHELE A, MCGEE, KEVIN F, MARRUFO, LAURA D, SAMBANDAM, ARUNA, LIU, SHUANG, XING, LI, SHIEH, HUEY S, BLEVIS-BAL, RADHIKA M, BOEHM, TERRI L, DEVRAJ, RAJESH, DEVADAS, BALEKUDRU, RUCKER, PAUL V, MADSEN, HEATHER M, OWEN, THOMAS, JEROME, KEVIN D, ALVIRA, EDGARDO, HICKORY, BRIAN S
Year of Publication 28.02.2013
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Year of Publication 28.02.2013
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SUPSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE
SELNESS, SHAUN R, NAING, WIN, WALKER, JOHN, SCOTT, IAN L, DURLEY, RICHARD, JEROME, KEVIN, D, BOEHM, TERRI, L, PROMO, MICHELE A, MCGEE, KEVIN F, MARRUFO, LAURA D, SAMBANDAM, ARUNA, LIU, SHUANG, XING, LI, SHIEH, HUEY S, BLEVIS-BAL, RADHIKA M, HITCHOCK, JEFF, DEVRAJ, RAJESH, DEVADAS, BALEKUDRU, RUCKER, PAUL V, MADSEN, HEATHER M, OWEN, THOMAS, ALVIRA, EDGARDO, HICKORY, BRIAN S
Year of Publication 31.12.2012
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Year of Publication 31.12.2012
Patent
Setin pýridínón sem stillar á P38 MAP kínasa
SHUANG LIU, WIN NAING, RICHARD C. DURLEY, EDGARDO ALVIRA, KEVIN D. JEROME, HEATHER M. MADSEN, RADHIKA M. BLEVIS-BAL, KEVIN F. MCGEE, JEFF HITCHCOCK, LI XING, LAURA D. MARRUFO, THOMAS OWEN, ARUNA SAMBANDAM, PAUL V. RUCKER, HUEY S. SHIEH, BALEKUDRU DEVADAS, BRIAN S. HICKORY, JOHN WALKER, SHAUN R. SELNESS, TERRI L. BOEHM, MICHELE A. PROMO, IAN L. SCOTT, RAJESH DEVRAJ
Year of Publication 15.05.2011
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Year of Publication 15.05.2011
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(R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY
REINHARD, EMILY J, TOLLEFSON, MICHAEL B, SIKORSKI, JAMES A, DURLEY, RICHARD C, HAMME, ASHTON T, FOBIAN, YVETTE M, WANG, LIJUAN, PROMO, MICHELE A, MASSA, MARK A, GRAPPERHAUS, MARGARET L, SPANGLER, DALE P, RUEPPEL, MELVIN L, VERNIER, WILLIAM F, MISCHKE, DEBORAH A, NORTON, MONICA B, HICKORY, BRIAN S
Year of Publication 26.04.2011
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Year of Publication 26.04.2011
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SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE
SELNESS, SHAUN R, NAING, WIN, DURLEY, RICHARD C, WALKER, JOHN, HITCHCOCK, JEFF, SCOTT, IAN L, PROMO, MICHELE A, MCGEE, KEVIN F, MARRUFO, LAURA D, SAMBANDAM, ARUNA, LIU, SHUANG, XING, LI, SHIEH, HUEY S, BLEVIS-BAL, RADHIKA M, BOEHM, TERRI L, DEVRAJ, RAJESH, DEVADAS, BALEKUDRU, RUCKER, PAUL V, MADSEN, HEATHER M, OWEN, THOMAS, JEROME, KEVIN D, ALVIRA, EDGARDO, HICKORY, BRIAN S
Year of Publication 19.04.2011
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Year of Publication 19.04.2011
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SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY
REINHARD, EMILY J, TOLLEFSON, MICHAEL B, SIKORSKI, JAMES A, DURLEY, RICHARD C, HAMME, ASHTON T, FOBIAN, YVETTE M, WANG, LIJUAN, PROMO, MICHELE A, PARNAS, BARRY L, MASSA, MARK A, GRAPPERHAUS, MARGARET L, SPANGLER, DALE P, RUEPPEL, MELVIN L, VERNIER, WILLIAM F, MISCHKE, DEBORAH A, NORTON, MONICA B, HICKORY, BRIAN S
Year of Publication 27.04.2010
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Year of Publication 27.04.2010
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(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity
Sikorsky, James A, Durley, Richard C, Grapperhaus, Margaret L, Massa, Mark A, Reinhard, Emily J, Fobian, Yvette M, Tollefson, Michael B, Wang, Lijuan, Hickory, Brian S, Norton, Monica B, Vernier, William F, Mischke, Deborah A, Promo, Michele A, Hamme, Ashton T, Spangler, Dale P, Rueppel, Melvin L
Year of Publication 20.04.2010
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Year of Publication 20.04.2010
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(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity
FOBIAN YVETTE M, GRAPPERHAUS MARGARET L, RUEPPEL MELVIN L, PROMO MICHELE A, HAMME ASHTON T, DURLEY RICHARD C, MASSA MARK A, REINHARD EMILY J, SIKORSKY JAMES A, HICKORY BRIAN S, MISCHKE DEBORAH A, NORTON MONICA B, SPANGLER DALE P, VERNIER WILLIAM F, WANG LIJUAN, TOLLEFSON MICHAEL B
Year of Publication 20.04.2010
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Year of Publication 20.04.2010
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AMIDINO COMPOUND AND SALTS THEREOF USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS
MOORMANN, ALAN E, DURLEY, RICHARD C, HANSEN, DONALD W, SNYDER, JEFFREY S, TSYMBALOV, SOFYA, WEBBER, RONALD KEITH, GANSER, SCOTT S, BERGMANIS, ARIJA A, SCHARTMAN, RICHARD R, TRIVEDI, MAHIMA, HAGEN, TIMOTHY J, HALLINAN, E. ANN, PROMO, MICHELLE A, AWASTHI, ALOK K, PITZELE, BARNETT S, HICKORY, BRIAN S
Year of Publication 16.02.2010
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Year of Publication 16.02.2010
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SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE
MADSEN HEATHER M, NAING WIN, WALKER JOHN, DEVRAJ RAJESH, PROMO MICHELE A, MCGEE KEVIN F, DURLEY RICHARD C, BLEVIS-BAL RADHIKA M, OWEN THOMAS, SELNESS SHAUN R, ALVIRA EDGARDO, SHIEH HUEY S, JEROME KEVIN D, BOEHM TERRI L, LIU SHUANG, HITCHCOCK JEFF, SAMBANDAM ARUNA, DEVADAS BALEKUDRU, HICKORY BRIAN S, SCOTT IAN L, MARRUFO LAURA D, RUCKER PAUL V, XING LI
Year of Publication 29.01.2010
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Year of Publication 29.01.2010
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