Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics
Davda, Jasmine, Declerck, Paul, Hu-Lieskovan, Siwen, Hickling, Timothy P, Jacobs, Ira A, Chou, Jeffrey, Salek-Ardakani, Shahram, Kraynov, Eugenia
Published in Journal for immunotherapy of cancer (15.04.2019)
Published in Journal for immunotherapy of cancer (15.04.2019)
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Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics
Siegel, Michel, Steiner, Guido, Franssen, Linnea C, Carratu, Francesca, Herron, James, Hartman, Katharina, Looney, Cary M, Ducret, Axel, Bray-French, Katharine, Rohr, Olivier, Hickling, Timothy P, Smith, Noel, Marban-Doran, Céline
Published in Pharmaceutics (01.12.2022)
Published in Pharmaceutics (01.12.2022)
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Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics
Siegel, Michel, Padamsey, Aman, Bolender, Anna-Lena, Hargreaves, Patrick, Fraidling, Johannes, Ducret, Axel, Hartman, Katharina, Looney, Cary M, Bertinetti-Lapatki, Cristina, Rohr, Olivier, Hickling, Timothy P, Kraft, Thomas E, Marban-Doran, Céline
Published in Frontiers in immunology (20.08.2024)
Published in Frontiers in immunology (20.08.2024)
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Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity
Siegel, Michel, Bolender, Anna-Lena, Ducret, Axel, Fraidling, Johannes, Hartman, Katharina, Looney, Cary M, Rohr, Olivier, Hickling, Timothy P, Kettenberger, Hubert, Lechmann, Martin, Marban-Doran, Céline, Kraft, Thomas E
Published in Frontiers in immunology (28.08.2024)
Published in Frontiers in immunology (28.08.2024)
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HLAII peptide presentation of infliximab increases when complexed with TNF
Casasola-LaMacchia, Andrea, Seward, Robert Joseph, Tourdot, Sophie, Willetts, Matthew, Kruppa, Gary, Agostino, Michael J, Bergeron, Gabrielle, Ahyi-Amendah, Nathalie, Ciarla, Andrew, Lu, Zhaojiang, Kim, Hai-Young, Hickling, Timothy P, Neubert, Hendrik
Published in Frontiers in immunology (13.09.2022)
Published in Frontiers in immunology (13.09.2022)
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Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes
Hartman, Katharina, Steiner, Guido, Siegel, Michel, Looney, Cary M, Hickling, Timothy P, Bray-French, Katharine, Springer, Sebastian, Marban-Doran, Céline, Ducret, Axel
Published in Biology (Basel, Switzerland) (01.09.2023)
Published in Biology (Basel, Switzerland) (01.09.2023)
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Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding
OWSIANKA, Ania M, TIMMS, Judith M, TARR, Alexander W, BROWN, Richard J. P, HICKLING, Timothy P, SZWEJK, Aleksandra, BIENKOWSKA-SZEWCZYK, Krystyna, THOMSON, Brian J, PATEL, Arvind H, BALL, Jonathan K
Published in Journal of Virology (01.09.2006)
Published in Journal of Virology (01.09.2006)
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Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain
Müller, Mischa R., Saunders, Kenneth, Grace, Christopher, Jin, Macy, Piche-Nicholas, Nicole, Steven, John, O'Dwyer, Ronan, Wu, Leeying, Khetemenee, Lam, Vugmeyster, Yulia, Hickling, Timothy P., Tchistiakova, Lioudmila, Olland, Stephane, Gill, Davinder, Jensen, Allan, Barelle, Caroline J.
Published in mAbs (01.11.2012)
Published in mAbs (01.11.2012)
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Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Townsend, Sue, Fennell, Brian J., Apgar, James R., Lambert, Matthew, McDonnell, Barry, Grant, Joanne, Wade, Jason, Franklin, Edward, Foy, Niall, Shúilleabháin, Deirdre Ní, Fields, Conor, Darmanin-Sheehan, Alfredo, King, Amy, Paulsen, Janet E., Hickling, Timothy P., Tchistiakova, Lioudmila, Cunningham, Orla, Finlay, William J. J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
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Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33
TARR, Alexander W, OWSIANKA, Ania M, TIMMS, Judith M, MCCLURE, C. Patrick, BROWN, Richard J. P, HICKLING, Timothy P, PIETSCHMANN, Thomas, BARTENSCHLAGER, Ralf, PATEL, Arvind H, BALL, Jonathan K
Published in Hepatology (Baltimore, Md.) (01.03.2006)
Published in Hepatology (Baltimore, Md.) (01.03.2006)
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Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33
Tarr, Alexander W, Owsianka, Ania M, Jayaraj, Dhanya, Brown, Richard J. P, Hickling, Timothy P, Irving, William L, Patel, Arvind H, Ball, Jonathan K
Published in Journal of general virology (01.11.2007)
Published in Journal of general virology (01.11.2007)
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Journal Article
Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents
Strand, Vibeke, Gonçalves, Joao, Hickling, Timothy P., Jones, Heather E., Marshall, Lisa, Isaacs, John D.
Published in BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy (01.02.2020)
Published in BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy (01.02.2020)
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Analysis of the binding of hepatitis C virus genotype 1a and 1b E2 glycoproteins to peripheral blood mononuclear cell subsets
Yamada, Eriko, Montoya, Maria, Schuettler, Christian G, Hickling, Timothy P, Tarr, Alexander W, Vitelli, Alessandra, Dubuisson, Jean, Patel, Arvind H, Ball, Jonathan K, Borrow, Persephone
Published in Journal of general virology (01.09.2005)
Published in Journal of general virology (01.09.2005)
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Journal Article
Correction to: Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents
Strand, Vibeke, Gonçalves, Joao, Hickling, Timothy P., Jones, Heather E., Marshall, Lisa, Isaacs, John D.
Published in BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy (01.04.2020)
Published in BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy (01.04.2020)
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The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models
Palsson, Sirus, Hickling, Timothy P, Bradshaw-Pierce, Erica L, Zager, Michael, Jooss, Karin, O'Brien, Peter J, Spilker, Mary E, Palsson, Bernhard O, Vicini, Paolo
Published in BMC systems biology (28.09.2013)
Published in BMC systems biology (28.09.2013)
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CD8+ T Lymphocyte Epitopes From The Herpes Simplex Virus Type 2 ICP27, VP22 and VP13/14 Proteins To Facilitate Vaccine Design And Characterization
Platt, Rebecca J, Khodai, Tansi, Townend, Tim J, Bright, Helen H, Cockle, Paul, Perez-Tosar, Luis, Webster, Rob, Champion, Brian, Hickling, Timothy P, Mirza, Fareed
Published in Cells (Basel, Switzerland) (04.01.2013)
Published in Cells (Basel, Switzerland) (04.01.2013)
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