TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life
Davé, Emma, Durrant, Oliver, Dhami, Neha, Compson, Joanne, Broadbridge, Janice, Archer, Sophie, Maroof, Asher, Whale, Kevin, Menochet, Karelle, Bonnaillie, Pierre, Barry, Emily, Wild, Gavin, Peerboom, Claude, Bhatta, Pallavi, Ellis, Mark, Hinchliffe, Matthew, Humphreys, David P, Heywood, Sam P
Published in mAbs (2023)
Published in mAbs (2023)
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Journal Article
Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering
Humphreys, David P., Heywood, Sam P., Henry, Alistair, Ait-Lhadj, Layla, Antoniw, Pari, Palframan, Roger, Greenslade, Kevin J., Carrington, Bruce, Reeks, Dominc G., Bowering, Leigh C., West, Shauna, Brand, Helen A.
Published in Protein engineering, design and selection (01.05.2007)
Published in Protein engineering, design and selection (01.05.2007)
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Towards a universal disulphide stabilised single chain Fv format: importance of interchain disulphide bond location and vL–vH orientation
Weatherill, Eve E., Cain, Katharine L., Heywood, Sam P., Compson, Joanne E., Heads, James T., Adams, Ralph, Humphreys, David P.
Published in Protein engineering, design and selection (01.07.2012)
Published in Protein engineering, design and selection (01.07.2012)
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Journal Article
PEGylation prolongs the pulmonary retention of an anti-IL-17A Fab’ antibody fragment after pulmonary delivery in three different species
Freches, Danielle, Patil, Harshad P., Machado Franco, Maria, Uyttenhove, Catherine, Heywood, Sam, Vanbever, Rita
Published in International journal of pharmaceutics (15.04.2017)
Published in International journal of pharmaceutics (15.04.2017)
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Journal Article
Engineering of Escherichia coli to improve the purification of periplasmic Fab' fragments: changing the pI of the chromosomally encoded PhoS/PstS protein
Humphreys, David P, Heywood, Sam P, King, Lloyd M, Bowering, Leigh C, Turner, James P, Lane, Sarah E
Published in Protein expression and purification (01.09.2004)
Published in Protein expression and purification (01.09.2004)
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Journal Article
IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design
Stoyle, Chloe L, Stephens, Paul E, Humphreys, David P, Heywood, Sam, Cain, Katharine, Bulleid, Neil J
Published in Biochemical journal (15.09.2017)
Published in Biochemical journal (15.09.2017)
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Journal Article
The rational design of affinity-attenuated OmCI for the purification of complement C5
Macpherson, Alex, Liu, Xiaofeng, Dedi, Neesha, Kennedy, Jeffery, Carrington, Bruce, Durrant, Oliver, Heywood, Sam, van den Elsen, Jean, Lawson, Alastair D.G.
Published in The Journal of biological chemistry (07.09.2018)
Published in The Journal of biological chemistry (07.09.2018)
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Journal Article
Production, purification and biological characterization of mono-PEGylated anti-IL-17A antibody fragments
Koussoroplis, Salome-Juliette, Heywood, Sam, Uyttenhove, Catherine, Barilly, Céline, Van Snick, Jacques, Vanbever, Rita
Published in International journal of pharmaceutics (15.09.2013)
Published in International journal of pharmaceutics (15.09.2013)
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Journal Article
Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life
Adams, Ralph, Griffin, Laura, Compson, Joanne E, Jairaj, Mark, Baker, Terry, Ceska, Tom, West, Shauna, Zaccheo, Oliver, Davé, Emma, Lawson, Alastair Dg, Humphreys, David P, Heywood, Sam
Published in mAbs (02.10.2016)
Published in mAbs (02.10.2016)
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Journal Article
Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding
Davé, Emma, Adams, Ralph, Zaccheo, Oliver, Carrington, Bruce, Compson, Joanne E, Dugdale, Sarah, Airey, Michael, Malcolm, Sarah, Hailu, Hanna, Wild, Gavin, Turner, Alison, Heads, James, Sarkar, Kaushik, Ventom, Andrew, Marshall, Diane, Jairaj, Mark, Kopotsha, Tim, Christodoulou, Louis, Zamacona, Miren, Lawson, Alastair D, Heywood, Sam, Humphreys, David P
Published in mAbs (02.10.2016)
Published in mAbs (02.10.2016)
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Journal Article
인간 IL-13 및 IL-17에 대해 결합 특이성을 갖는 다중 특이적 항체
LIGHTWOOD DANIEL JOHN, KHAN ADNAN RAHMAN, DAVE EMMA, STANYON SARAH JAYNE, HUMPHREYS DAVID PAUL, HEYWOOD SAM PHILIP, BARRY EMILY MARY CAIRISTINE
Year of Publication 23.08.2022
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Year of Publication 23.08.2022
Patent
항-FCRN 항체
BHATTA PALLAVI, DAVE EMMA, HUMPHREYS DAVID PAUL, HEYWOOD SAM PHILIP, SMITH BRYAN JOHN
Year of Publication 08.01.2018
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Year of Publication 08.01.2018
Patent
Fab-dsFv 다량체 종에서 단량체 항체의 백분율을 증가시키는 방법
WILD GAVIN BARRY, HEYWOOD SAM PHILIP, HANIF RAZWAN, LE PAGE CHRISTOPHER JOHN
Year of Publication 15.12.2017
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Year of Publication 15.12.2017
Patent
재조합 항체 분자의 단량체화 방법
WILD GAVIN BARRY, HEYWOOD SAM PHILIP, HANIF RAZWAN, LE PAGE CHRISTOPHER JOHN
Year of Publication 15.12.2017
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Year of Publication 15.12.2017
Patent
TNF-알파, IL-17A 및 IL-17F에 대해 특이성을 갖는 다중특이적 항체 분자
ADAMS RALPH, BHATTA PALLAVI, MARSHALL DIANE, LIGHTWOOD DANIEL JOHN, SHAW STEVAN GRAHAM, DAVE EMMA, HUMPHREYS DAVID PAUL, HEYWOOD SAM PHILIP
Year of Publication 08.08.2018
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Year of Publication 08.08.2018
Patent